Influence of aging on gastric emptying of liquids, small intestine transit, and fecal output in rats

Smits, Geert Jm; Lefebvre, Romain

doi:10.1016/0531-5565(96)00029-0

Cited by 64 publications

(43 citation statements)

References 29 publications

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“…In the current study we have shown that fecal output is reduced with age and that this reduction is due primarily to a decrease in the number of pellets produced and a reduction in the water content of the pelletsas the average weight of the fecal pelletsfrom 3 and 24 month old animals was not significantly different.Food intake also remained unchanged with age. These data are consistent with a similar study performed on rats (Smits and Lefebvre, 1996), but differ from a model of premature aging, the klotho mouse, where reduced fecal output was linked to a decrease in food intake (Asuzu et al, 2011). Increases in the rate of nutrient absorption with age could also contribute to our observations, although this seems unlikely based on earlier studies, which suggest that the rate of absorption of nutrients from the small intestine is reduced with increasing age (Drozdowski and Thomson, 2006;Thomson, 2009).…”

Section: Effects Of Age On Fecal Output and The Properties Of Fecal Psupporting

confidence: 71%

“…A decrease in pellet water content wasalso reported in the rat between 12 and 24 months, although this change reflected a decrease in water consumption (Smits and Lefebvre, 1996). A decrease in the water content of fecal pellets has also been observed in aged rabbits (Braaten et al, 1988).…”

Section: Effects Of Age On Fecal Output and The Properties Of Fecal Pmentioning

confidence: 90%

“…However, there are limited studies investigating the effects of age on motility. To date only a single study has detailed the changes in fecal output in wild type aged rodents (Smits and Lefebvre, 1996). This study showed a decrease in total fecal output between 12 and 24 month rats, due to a significant reduction in both the number of pellets produced and the wet mass of the pellets.…”

Section: Introductionmentioning

confidence: 89%

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Impaired colonic motility and reduction in tachykinin signalling in the aged mouse

Patel

Fidalgo

et al. 2014

Experimental Gerontology

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Section: Effects Of Age On Fecal Output and The Properties Of Fecal Psupporting

confidence: 71%

Section: Effects Of Age On Fecal Output and The Properties Of Fecal Pmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 89%

See 1 more Smart Citation

Impaired colonic motility and reduction in tachykinin signalling in the aged mouse

Patel

Fidalgo

et al. 2014

Experimental Gerontology

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“…Gastric emptying was performed by a slight modification of the method described by Smits and Lefebvre (25). Briefly, after an overnight fast the animals were orally administered a standard meal for 2 min.…”

Section: Gastric Emptyingmentioning

confidence: 99%

Gastric Emptying in Animal Models of Human Diabetes: Correlation to Blood Glucose Level and Gut Neuroendocrine Peptide Content

Spångéus

2002

Upsala Journal of Medical Sciences

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Gastric emptying was measured in non-obese diabetic (NOD) and in obese diabetic mice. The feces were collected and the water content was determined. The neuroendocrine peptides known to regulate gastrointestinal motility, namely secretin, gastric inhibitory peptide (GIP), motilin, somatostatin, peptide YY (PYY), substance P, vasoactive intestinal polypeptide (VIP) and galanin, were measured in tissue extracts of different segments of the gut by radioimmunoassay. Whereas the gastric emptying of NOD mice was significantly slower than that of controls, that of the obese diabetic mice was unaltered. The gastric emptying of NOD mice, but not that of obese diabetic mice, correlated with the blood glucose level. The feces weight and water content in NOD mice was significantly higher than controls. The feces water content in obese diabetic mice was significantly lower than that of controls. The concentrations of antral somatostatin, VIP and galanin, and duodenal secretin as well as jejunal motilin in NOD mice were higher than those of controls. Duodenal GIP and colonic PYY concentration in NOD mice was lower than controls. Duodenal GIP and VIP, and colonic somatostatin and VIP levels were lower in obese diabetic mice than controls. Secretin and motilin levels correlated with gastric emptying in NOD mice. The high duodenal concentration of secretin might reflect high synthesis and release of this hormone, and may therefore be among the factors that caused slow gastric emptying in the NOD mice. The increase in concentration of motilin observed in NOD mice may be caused by impaired release of this hormone as a result of hyperglycemia. Whereas the high concentrations of antral VIP and galanin and the low level of colonic PYY in diabetic NOD mice may contribute to the development of diarrhea in NOD mice, the decreased levels of duodenal and colonic VIP and colonic somatostatin in obese diabetic mice may account for the constipation encountered in these animals.

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“…Com o avançar da idade, ocorre diminuição na motilidade esofágica e colônica (BUTT et al, 1993;HOLLINS;CASTELL, 1974;KHAN et al, 1977;WADE;EVANS;LIEB, 2002), comprometimento do esvaziamento gástrico (BROGNA et al, 1999;HOROWITZ et al, 1984;SMITS;LEFEBVRE, 1996) e aumento no trânsito intestinal (ANU-RAS; LEONING-BAUCKE, 1984;WADE;EVANS;LIEB, 2002). A alteração do número de neurônios mioentéricos é um dos fatores que contribuem para o comprometimento da motilidade do tubo digestório ao longo do envelhecimento (DE SOUZA et al, 1993;EL-SALHY;SABDSTRÖM;HOLMLUND, 1999;GABELLA, 1989;GOMES;DE SOU-ZA;LIBERTI, 1997;POWLEY, 2001POWLEY, , 2007SANTER;BAKER, 1988).…”

Section: Introductionunclassified

Efeito Da Atividade Física Moderada Sobre Neurônios Mioentéricos Nitrérgicos Do Íleo De Ratos De Meia Idade

Major

Clebis

Mari

et al. 2016

ArqVet

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MAJOR, J. A. de A.; CLEBIS, N. K.; MARI, R. de B.; GAGLIARDO, K. M.; GUIMARÃES, J. P.; SOUZA, R. R. de; STA-BILLE, S. R.; DIAS, N. S. de O.; GERMANO, R. de M. Efeito da atividade física moderada sobre neurônios mioentéricos nitrérgicos do íleo de ratos de meia idade. Arq. Ciênc. Vet. Zool. UNIPAR, Umuarama, v. 18, n. 3, p. 141-147, jul./set. 2015. RESUMO:Poucos são os relatos a respeito do efeito da atividade física sobre o plexo mioentérico ao longo do envelhecimento. Portanto, analisaram-se os neurônios mioentéricos NADPH-diaforase positivos do íleo em ratos que envelheceram praticando atividade física a partir dos seis meses de vida. Dez ratos Wistar foram distribuídos em dois grupos (n = 5/grupo): S (ratos sedentários controles com 12 meses de idade) e T (ratos treinados com 12 meses de idade). Os animais do grupo T realizaram, dos seis aos 12 meses de idade, atividade física regulada conforme resultados obtidos em teste de esforço máximo. Ao final do período experimental, o íleo obtido de cada animal foi processado para a técnica de NADPH-diaforase para evidenciar neurônios mioentéricos em preparados de membrana e quantificar e mensurar a área do pericário desses neurônios. A área do pericário não diferiu (P> 0,05) entre o grupo S (218,49 µm2 ) e o grupo T (210,59 µm 2 ). A média de neurônios presente em 60 campos microscópicos de preparados de membranas no grupo S (126 neurônios) foi superior (P<0,05) a média encontrada no grupo T (93 neurônios), sugerindo que a atividade física pode inibir ou diminuir a expressão dos neurônios nitrérgicos em ratos de 12 meses de idade que praticaram atividade física desde os seis meses de vida. Os resultados quantitativos sugerem que a falta de atividade física regular propicia aumento na atividade dos neurônios nitrérgicos, contribuindo para o surgimento dos distúrbios da motricidade gastrointestinal que podem ocorrer ao longo do envelhecimento. PALAVRAS-CHAVE: Corrida em esteira. Exercício físico. Intestino. NADPH-diaforase. Plexo mioentérico. THE EFFECT OF MODERATE PHYSICAL ACTIVITY ON MYOENTERIC NITRERGIC NEURONS IN THE ILEUM OF MIDDLE-AGED RATSABSTRACT: There are only a few reports on the effect of physical activity in the myoenteric plexus throughout the aging process. For such, the positive myoenteric NADPH-diaphoresis neurons in the ileum of those rats that aged practicing physical activity from the sixth month were analyzed. Ten Wistar rats were distributed into two groups (n= 5/group): S (12 months-old control sedentary rats) and T (12 months-old trained rats). The animals from the T group practiced controlled physical activity from the age of 6 months to 12 months, according to the maximum effort test results. At the end of the experimental period, the ileum obtained from each animal was processed in the NADPH-diaphoresis technique to highlight myoenteric neurons in membrane preparations, and quantify and measure the perikaryon area from those neurons. The Perikaryon area did not differ (P>0.05) among the S group (218.49 µm 2 ) and the T group (210.59 µm 2 ). T...

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Influence of aging on gastric emptying of liquids, small intestine transit, and fecal output in rats

Cited by 64 publications

References 29 publications

Impaired colonic motility and reduction in tachykinin signalling in the aged mouse

Impaired colonic motility and reduction in tachykinin signalling in the aged mouse

Gastric Emptying in Animal Models of Human Diabetes: Correlation to Blood Glucose Level and Gut Neuroendocrine Peptide Content

Efeito Da Atividade Física Moderada Sobre Neurônios Mioentéricos Nitrérgicos Do Íleo De Ratos De Meia Idade

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