Influence of Alcoholism on Morbidity After Transurethral Prostatectomy

Tønnesen, Hanne; Schütten, Birgitte T.; Tollund, L; Hasselqvist, Philip; Klintorp, Søren

doi:10.1080/00365599.1988.11690408

Cited by 26 publications

(6 citation statements)

References 8 publications

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“…This phenomenon seems to be potentiated by stress for example, surgical operations (2,3). A marked depression in the number of circulating lymphocytes has been documented in alcoholics but no consistent depression in the number of other white cells has been reported (4).…”

Section: Introductionmentioning

confidence: 99%

Lymphopenia in Heavy Drinkers - Reversibility and Relation to the Duration of Drinking Episodes

Tønnesen¹,

Andersen²,

Pedersen³

et al. 1990

Annals of Medicine

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Seventy-four addictive alcoholic subjects were investigated shortly after a period of excessive drinking and were compared with 18 alcoholic subjects who had not been drinking for at least six months. No difference was observed in total white cell count or number of circulating granulocytes. Lymphocyte count was significantly lower in alcoholics whose last alcoholic bout had been three months or more, but after 30 days of abstinence the difference had disappeared. The depressed lymphocyte count did not correlate with other components of the drinking pattern. These results show that lymphopenia in alcoholics is a time-dependent and reversible event.

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Section: Introductionmentioning

confidence: 99%

Lymphopenia in Heavy Drinkers - Reversibility and Relation to the Duration of Drinking Episodes

Tønnesen¹,

Andersen²,

Pedersen³

et al. 1990

Annals of Medicine

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“…However, there are no clinical details, particularly about the indications for surgery, the stage of liver cirrhosis, and on smoking habits and alcohol consumption. During the last decade evidence suggests that alcoholism increases the perioperative risk during TURP [16]. Previous studies showed no evidence for excess prostate cancer, and some have even hypothesized a reduced risk of prostate cancer, in patients with alcoholic or nonalcoholic cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Postoperative mortality in patients with liver cirrhosis undergoing transurethral resection of the prostate: a Danish nationwide cohort study

et al. 2001

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Objective To examine the risk of 30‐day postoperative mortality from transurethral resection of the prostate (TURP) in patients with liver cirrhosis, who are reportedly at considerably increased perioperative risk. Patients and methods For the period 1 January 1977 to 31 December 1993, a population‐based cohort was identified comprising Danish patients diagnosed with liver cirrhosis and a random sample of Danes also undergoing TURP. Logistic regression models were used to estimate the association between liver cirrhosis, age, type of admission, comorbidity and 30‐day mortality. Results In a cohort of 23 133 patients with liver cirrhosis, 30 underwent TURP; 150 controls with no liver cirrhosis also underwent the same procedure. Of the patients with liver cirrhosis, 6.7% died within 30 days of TURP; the estimated adjusted odds ratio was 3.0 (95% confidence interval 0.4–22.9) for the 30‐day postoperative mortality in patients with liver cirrhosis compared with patients without (mortality 2%). Advanced age, comorbidity and acute admission seemed to be associated with an increased postoperative mortality. Conclusion This study indicates that TURP in patients with liver cirrhosis was associated with increased mortality.

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“…Suppression of the cellular immune function may easily explain the extremely high incidence of infections seen after major and minor, elective and acute surgery on asymptomatic alcoholic men and women (1 -5). Interestingly, routine cultivation of urine before and after transurethral prostatectomy showed no difference in the bacterial species between alcoholics and matched controls (2). The alcoholics did not develop unusual kinds of bacterial infection, and the infections showed no special pattern of postoperative resistance.…”

Section: Surgical Aspectsmentioning

confidence: 92%

Influence of alcohol on several physiological functions and its reversibility: a surgical view

Tennesen

1992

Acta Psychiatr Scand

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Alcohol intake influences several physiological functions, including the haemostatic system, the cellular immune defence and the cardiac function, but to a different degree depending on the drinking habits. Restoration of these functions after withdrawal seems time related. The haemostatic imbalance normalizes within two or three weeks of soberness while the immune system requires about two months to recover. Recent studies have showed very increased postoperative morbidity after surgery in alcohol abusers, which may be explained by alcohol‐induced physiological dysfunctions. Theoretically, two months of abstinence before a surgical procedure would diminish the increased postoperative morbidity among alcohol abusers. However, further investigation is necessary to establish a clinical effect of preoperative withdrawal from alcohol.

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Influence of Alcoholism on Morbidity After Transurethral Prostatectomy

Cited by 26 publications

References 8 publications

Lymphopenia in Heavy Drinkers - Reversibility and Relation to the Duration of Drinking Episodes

Lymphopenia in Heavy Drinkers - Reversibility and Relation to the Duration of Drinking Episodes

Postoperative mortality in patients with liver cirrhosis undergoing transurethral resection of the prostate: a Danish nationwide cohort study

Influence of alcohol on several physiological functions and its reversibility: a surgical view

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