Influence of alcoholism on the prognosis of schizophrenic patients.

Prediction of the Risk of Comorbid Alcoholism in Schizophrenia by Interaction of Common Genetic Variants in the Corticotropin-Releasing Factor System

“…The presence of comorbid AUD in as many as 35% of the GRAS population and the devastating psychosocial and clinical consequences agree well with other reports on schizophrenic patients. [11][12][13]62 The causal role of AUD in this overall aggravated situation is emphasized by the fact that schizophrenia-typical symptoms are not different between AUD and non-AUD groups. Surprisingly, at first view, patients with AUD have an earlier age at onset of schizophrenic prodrome and first schizophrenic episode compared with patients without AUD.…”

Platelet serotonin concentration in alcoholic subjects

“…Alcoholism is a heterogenous syndrome characterized by a high morbidity, comorbidity (Kozarić-Kovačić et al, 1995), treatment resistance, chronic course, and connected with a high suicidal rate. Alcoholism has been shown to be related to alterations in different neurobiological systems such as dopaminergic, serotonergic, noradrenergic, GABAergic, and beta-endorphin systems (Ratsma et al, 2002).…”

Substance Use Disorder Comorbidity in Schizophrenia

“…Şizofreni alt tiplerinin değerlendirildiği çalışmalarda alkol dışı madde bağımlılığının paranoid şizofrenide daha sık olduğu saptanmıştır. [46] Eş tanılı şizofreni hastalarının özkıyım oranları, eş tanılı olmayan hastalara oranla daha yüksektir, ayrıca Hamilton Depresyon Ölçeğinde daha yüksek skorlar ve daha düşük işlevsellik de bildirilmiştir. [11,[47][48][49] Özellikle kokain kullanan şizofreni tanılı hastalarda major depresyon ve özkıyım düşüncesi açısından daha da yüksek risk bildirilmiştir.…”