Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats

Chithra, P; Sajithlal, G.B; Chandrakasan, Gowri

doi:10.1016/s0378-8741(97)00112-8

Cited by 187 publications

(131 citation statements)

References 29 publications

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“…The Aloe administration influence collagen composition (more type III) and increased collagen cross linking for wound contraction and improving breaking strength [17]. It also increases synthesis of hyaluronic acid and dermatan sulfate in the granulation tissue of a healing wound [32].…”

Section: Wound Healingmentioning

confidence: 99%

Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review

Sahu¹,

Giri²,

Singh³

et al. 2013

224

117

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The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, minerals, enzymes, amino acids, natural sugars and other bioactive compounds with emollient, purgative, antimicrobial, anti inflammatory, anti-oxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic values for health care. This plant has potential to cure sunburns, burns and minor cuts, and even skin cancer. The external use in cosmetic primarily acts as skin healer and prevents injury of epithelial tissues, cures acne and gives a youthful glow to skin, also acts as extremely powerful laxative.

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Section: Wound Healingmentioning

confidence: 99%

Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review

Sahu¹,

Giri²,

Singh³

et al. 2013

224

117

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show abstract

“…Aloe vera (Aloe barbadensis MILLER) has long been used as an herbal medicine for healing skin wounds (6). It has been reported that Aloe vera gel stimulated dermal wound healing in rats by increasing collagen and glycosaminoglycan synthesis (7,8). In any event, the active ingredient of Aloe vera gel has never been identified.…”

Section: Introductionmentioning

confidence: 99%

Acemannan Stimulates Gingival Fibroblast Proliferation; Expressions of Keratinocyte Growth Factor-1, Vascular Endothelial Growth Factor, and Type I Collagen; and Wound Healing

et al. 2009

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Abstract. Aloe vera has long been used as a traditional medicine for inducing wound healing. Gingival fibroblasts (GFs) play an important role in oral wound healing. In this study, we investigated the effects of acemannan, a polysaccharide extracted from Aloe vera gel, on GF proliferation; keratinocyte growth factor-1 (KGF-1), vascular endothelial growth factor (VEGF), and type I collagen production; and oral wound healing in rats. [ 3 H]-Thymidine incorporation assay and ELISA were used. Punch biopsy wounds were created at the hard palate of male Sprague Dawley rats. All treatments (normal saline; 0.1% triamcinolone acetonide; plain 1% Carbopol ® ; and Carbopol ® containing 0.5%, 1%, and 2% acemannan (w /w)) were applied daily. Wounded areas and histological features were observed at day 7 after treatment. From our studies, acemannan at concentrations of 2, 4, 8, and 16 mg/ml significantly induced cell proliferation (P<0.05). Acemannan concentrations between 2 -16 mg/ml significantly stimulated KGF-1, VEGF, and type I collagen expressions (P<0.05). Wound healing of animals receiving Carbopol ® containing 0.5% acemannan (w /w) was significantly better than that of the other groups (P<0.05). These findings suggest that acemannan plays a significant role in the oral wound healing process via the induction of fibroblast proliferation and stimulation of KGF-1, VEGF, and type I collagen expressions.

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“…The wound healing potential of Tridax procumbens (Udupa et al, 1995), Trigonella foenumgraecum (Taranalli, Kuppast, 1996), Leucas lavandulaefolia (Saha et al, 1997), Aloe vera (Chitra et al, 1998), Ageratum conyzoides (Chah et al, 2006), Dendrophthoe falcate (Pattanayak et al, 2008) and Heliotropium indicum, Plumbago zeylanicum, Aca-lypha indica (Reddy et al, 2002) have shown promising healing activity.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ficus hispida L. on normal and dexamethasone suppressed wound healing

Murti

Lambole²,

Panchal³

2011

Braz. J. Pharm. Sci.

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Ethanolic extract of roots of Ficus hispida was investigated in normal and dexamethasone depressed healing conditions, using incision, excision and dead space wound models in albino rats. The root extract of Ficus hispida has shown the maximum breaking strength compared to control group. The rate of epithelialization and wound contraction in excision model was better as compared to control groups. There was significant increase in granulation tissue weight and hydroxyproline content in dead space model compared to control group. The antihealing effect of dexamethasone was also reverted by the administration of ethanolic extract of Ficus hispida in all the wound models .The results indicated that the root extract of Ficus hispida has a significant wound healing activity and also promotes healing in dexamethasone depressed healing conditions. Uniterms: Ficus hispida/pharmacognosy. Ficus hispida/ethanolic extract/wound healing activity. Wound healing/experimental study. O extrato etanólico de raízes de Ficus hispida foi ensaiado em ratos albinos normais e em condições de cicatrização deprimida por dexametasona, utilizando modelos de ferida por incisão, excisão e de espaço morto. O extrato da raiz de Ficus hispida mostrou a força máxima de tensão comparativamente ao grupo controle. A velocidade de epitelização e de contração da ferida no modelo de excisão foi melhor do que a dos grupos controles. Houve aumento significativo no peso do tecido de granulação e no conteúdo de hidroxiprolina no modelo de espaço morto comparativamente ao grupo controle. O efeito anticicatrizante da dexametasona foi, também, revertido pela administração do extrato etanólico de Ficus hispida em todos os modelos de feridas. Os resultados indicaram que o extrato de Ficus hispida tem atividade cicatrizante em feridas e, também, promove a cicatrização em condições de depressão de cicatrização pela dexametasona. Unitermos:Ficus hispida/Farmacognosia. Ficus hispida/extrato etanólico/atividade cicatrizante. Cicatrização/estudo experimental.

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Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats

Cited by 187 publications

References 29 publications

Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review

Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review

Acemannan Stimulates Gingival Fibroblast Proliferation; Expressions of Keratinocyte Growth Factor-1, Vascular Endothelial Growth Factor, and Type I Collagen; and Wound Healing

Effect of Ficus hispida L. on normal and dexamethasone suppressed wound healing

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Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats

Cited by 187 publications

References 29 publications

Therapeutic and Medicinal Uses of &lt;i&gt;Aloe vera&lt;/i&gt;: A Review

Therapeutic and Medicinal Uses of &lt;i&gt;Aloe vera&lt;/i&gt;: A Review

Acemannan Stimulates Gingival Fibroblast Proliferation; Expressions of Keratinocyte Growth Factor-1, Vascular Endothelial Growth Factor, and Type I Collagen; and Wound Healing

Effect of Ficus hispida L. on normal and dexamethasone suppressed wound healing

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Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review

Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review