Influence of altitudinal variation on the total phenolic and flavonoid content of <i>Acacia</i> and <i>Ziziphus</i> honey

Suleiman, Mohamed Hammad Adam; ALaerjani, Wed Mohammed Ali; Mohammed, Mohamed Elimam Ahamed

doi:10.1080/10942912.2020.1842445

Cited by 12 publications

(5 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, Suleiman et al (2020) showed a strong positive correlation between altitude and TPC (total phenolic content) and TFC (total flavonoid content) of Acacia honey. In contrast, they found that the TPC and TFC of Ziziphus honey were strongly negatively correlated with altitude [ 37 ]. It has also been revealed in recent research that the level of bioactive compounds of extra virgin olive oil strongly varied according to the altitude [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Geographical Location on the Phenolic and Mineral Composition of Chetoui Olive Leaves

Zakraoui

Hannachi

Pasković

et al. 2023

Foods

View full text Add to dashboard Cite

In this study, we investigated the influence of pedological parameters and variation of altitude on the mineral nutrients, phenolic compounds, and antioxidant activities of olive leaves. Samples of the Chetoui cultivar were collected from eight geographical locations with different altitudes. Levels of phenolic compounds varied according to the altitude. Classification of the locations revealed that altitude 1 (>500 m) was characterized by high levels of secoiridoids and simple phenols, while altitude 2 (500–300 m) and altitude 3 (<300 m) were higher in flavonoids. Levels of Mn, Ca and B in the leaves and level of Zn in the soil were significantly correlated with the abundance of oleuropein and luteolin-7-O glucoside, the most important phenols in Chetoui olive leaves. The results suggest that, in addition to pedological criteria, environmental conditions also influence the formation of phenolic compounds.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Geographical Location on the Phenolic and Mineral Composition of Chetoui Olive Leaves

Zakraoui

Hannachi

Pasković

et al. 2023

Foods

View full text Add to dashboard Cite

show abstract

“…Honey content and antioxidant potential may vary according to many factors, including botanical source, region, climatic conditions, seasonal factors, entomological origin, altitude, etc. [ 61 , 62 ]. Thus, this study aimed to investigate the antioxidant potential of identified phytochemicals in ZH derived from the Hail region and to characterize its specificity.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Composition, Antioxidant, and Anticancer Activities of Sidr Honey: In Vitro and In Silico Computational Investigation

Bouali

Hamadou

Badraoui

et al. 2022

Life

View full text Add to dashboard Cite

Cancer is one of the major causes of death worldwide. The repercussions of conventional therapeutic approaches present a challenge in the delivery of new effective treatments. Thus, more attention is being awarded to natural products, mainly honey. Honey could be the basis for the development of new therapies for cancer patients. The aim of this study is to assess the phytochemical profiling, antioxidant, drug-likeness properties, and anticancer activity of Ziziphus honey (ZH) derived from the Hail region of Saudi Arabia. The phytochemical profiling using high resolution-liquid chromatography mass spectrometry (HR-LCMS) revealed 10 compounds belonging to several familial classes and one tripeptide. Potential antioxidant activity was noted as assessed by DPPH (IC50 0.670 mg/mL), ABTS (IC50 3.554 mg/mL), and β-carotene (IC50 > 5 mg/mL). The ZH exerted a notable cytotoxic effect in a dose-dependent manner against three cancer cell lines: lung (A549), breast (MCF-7), and colon (HCT-116), with respective IC50 values of 5.203%, 6.02%, and 7.257%. The drug-likeness investigation unveiled that most of the identified compounds meet Lipinski’s rule. The molecular docking analysis revealed interesting antioxidant and anticancer activities for most targeted proteins and supported the in vitro findings. The Miraxanthin-III compound exhibited the most stabilized interaction. This study provides deeper insights on ZH as prominent source of bioactive compounds with potent antioxidant and anticancer effects.

show abstract

“…Additionally, the content of polyphenols of L. caerulea may differ based on differences in the extraction approach [59]. Polyphenol contents can also be influenced by altitude [61]. Cell culture conditions used could also explain these contrasting results.…”

Section: Discussionmentioning

confidence: 99%

Fermentation of Vaccinium floribundum Berries with Lactiplantibacillus plantarum Reduces Oxidative Stress in Endothelial Cells and Modulates Macrophages Function

et al. 2022

View full text Add to dashboard Cite

Accumulating evidence suggests that high consumption of natural antioxidants promotes health by reducing oxidative stress and, thus, the risk of developing cardiovascular diseases. Similarly, fermentation of natural compounds with lactic acid bacteria (LAB), such as Lactiplantibacillus plantarum, enhances their beneficial properties as regulators of the immune, digestive, and cardiovascular system. We investigated the effects of fermentation with Lactiplantibacillus plantarum on the antioxidant and immunomodulatory effects of Pushgay berries (Vaccinium floribundum, Ericaceae family) in human umbilical vein endothelial cells (HUVECs) and macrophage cell line RAW264.7. Polyphenol content was assayed by Folin–Ciocalteu and HPLC-MS/MS analysis. The effects of berries solutions on cell viability or proliferation were assessed by WST8 (2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt and Lactate dehydrogenase (LDH) release, Trypan blue exclusion test, and Alamar blue assay. Antioxidant activity was evaluated by a cell-based chemiluminescent probe for the detection of intracellular H2O2 production in HUVECs. Heme oxygenase-1 (HO-1) expression levels were investigated by RT-qPCR. Glutathione reductase (GR), glutathione peroxidase (Gpx), superoxide dismutase (SOD), and catalase (CAT) activities, as markers of intracellular antioxidant defense, were evaluated by spectrophotometric analysis. The immunomodulatory activity was examined in RAW 264.7 by quantification of inducible nitric oxide synthase (iNOS) and Tumor Necrosis Factor—alpha (TNFα) by RT-qPCR. Data showed that fermentation of Pushgay berries (i) enhances the content of quercetin aglycone, and (ii) increases their intracellular antioxidant activity, as indicated by the reduction in H2O2-induced cell death and the decrease in H2O2-induced HO-1 gene expression in HUVECs treated for 24 h with fermented berries solution (10 µg/mL). Moreover, treatment with Pushgay berries for 72 h (10 µg/mL) promotes cells growth in RAW 264.7, and only fermented Pushgay berries increase the expression of iNOS in the same cell line. Taken together, our results show that LAB fermentation of Pushgay berries enhances their antioxidant and immunomodulatory properties.

show abstract

Influence of altitudinal variation on the total phenolic and flavonoid content of Acacia and Ziziphus honey

Cited by 12 publications

References 41 publications

Effect of Geographical Location on the Phenolic and Mineral Composition of Chetoui Olive Leaves

Effect of Geographical Location on the Phenolic and Mineral Composition of Chetoui Olive Leaves

Phytochemical Composition, Antioxidant, and Anticancer Activities of Sidr Honey: In Vitro and In Silico Computational Investigation

Fermentation of Vaccinium floribundum Berries with Lactiplantibacillus plantarum Reduces Oxidative Stress in Endothelial Cells and Modulates Macrophages Function

Contact Info

Product

Resources

About