Influence of amine-modified poly(vinyl alcohol)s on vibrating-membrane nebulizer performance and lung toxicity

Biophysical Activity of Impaired Lung Surfactant upon Exposure to Polymer Nanoparticles

“…Thus, it is emphasized to define a suitable balance between the benefits and potential side effects of lung-delivered polymers and particulate matter. As an example, one recent study compared the impact of a series of positively charged poly­(vinyl alcohol)­s on nebulizer performance and lung toxicity, where the polymer structure (i.e., amine density) and total lung dose were identified as main triggers for significant lung injury.…”

“…Thus, it is emphasized to define a suitable balance between the benefits and potential side effects of lung-delivered polymers and particulate matter. As an example, one recent study compared the impact of a series of positively charged poly(vinyl alcohol)s on nebulizer performance and lung toxicity, 58 where the polymer structure (i.e., amine density) and total lung dose were identified as main triggers for significant lung injury. While some of the surprising findings, which occur when incubating lung surfactant with particulate matter, 20−26 can be anticipated/explained from/by molecular dynamics simulations, 59 scant experimental information is available describing the impact of nanomedicines on the essential biophysical function of the lung lining layer under predisposed conditions of airway diseases.…”

Characterization and comparison of Re-Du-Ning aerosol particles generated by different jet nebulizers

“…7,8 These nebulizers can produce distinct size aerosol particles, which may deposit in different locations of the respiratory system aer inhalation, and result in various therapeutic effects on respiratory diseases. 9 Therefore, the choice of nebulizer device should be considered carefully and the inhalation performance of these nebulizers for each drug should be determined.…”