Influence of amino acids on the aggregation behavior and drug solubilization of branched block copolymers

Chang, Dening; Niu, Shange; Chu, Haiping; Zang, Dejin; Sun, Jie; Wang, Xiaojing; Li, Teng

doi:10.1016/j.molliq.2022.119011

Cited by 6 publications

(2 citation statements)

References 42 publications

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“…Thus, a decrease in the solubility of the copolymer chain is observed which leads to greater aggregation. As a consequence, participation of more unimers in micelle formation is seen and are also supported by the enhancement in aggregation values (Chang et al, 2022; Pillai et al, 2016).…”

Section: Resultsmentioning

confidence: 73%

Amino acids induced modulations in linear PEO‐PPO‐PEO triblock copolymer microstructures and its exploration in prototypical drug solubilization

Chakrabarti,

Kakkad,

Desai

et al. 2023

J Surfact & Detergents

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This manuscript explains the effect of biologically important additives on the micellar behavior of an ethylene oxide‐propylene oxide (PEO101‐PPO56‐PEO101) based linear block copolymer, Poloxamer 407.The effect of common pharmaceutical excipients and three vital amino acids viz. alanine, glycine, and lysine (Ala, Gly, and Lys) is examined with the help of cloud point (CP), dynamic light scattering (DLS), and small angle neutron scattering (SANS) techniques. The drug solubilization ability for the copolymer was checked for two model drugs Quercetin (QCT) and Ibuprofen (IBU) with the help of high‐performance liquid chromatography (HPLC) in the presence/absence of additives such as Ala, Gly, and Lys. The observed results reveal that higher amino acid concentrations, favor the solubilization of drug which can potentially benefit the use of these biocompatible copolymers in pharmaceutical and biopharma industries.

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Section: Resultsmentioning

confidence: 73%

Amino acids induced modulations in linear PEO‐PPO‐PEO triblock copolymer microstructures and its exploration in prototypical drug solubilization

Chakrabarti,

Kakkad,

Desai

et al. 2023

J Surfact & Detergents

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“…Amino acids occur in a number of biomedical applications, with and without salts, organic solvents, and other components [ [33] , [34] , [35] , [36] ]. Solubility data for amino acids [ [37] , [38] , [39] , [40] ] are sparce, and little is known about amino-acid particles.…”

Section: Introductionmentioning

confidence: 99%

Size control of precipitated particles of amino acids using a bubble column evaporator

Nafi¹,

Taseidifar²,

Pashley³

et al. 2023

Heliyon

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Deformable nanocarriers for enhanced drug delivery and cancer therapy

Cao,

Liu,

Yang

2024

Exploration

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Recently, the field of nanomedicine has witnessed substantial advancements in the development of nanocarriers for targeted drug delivery, emerges as promising platforms to enhance therapeutic efficacy and minimize adverse effects associated with conventional chemotherapy. Notably, deformable nanocarriers have garnered considerable attention due to their unique capabilities of size changeable, tumor‐specific aggregation, stimuli‐triggered disintegration, and morphological transformations. These deformable nanocarriers present significant opportunities for revolutionizing drug delivery strategies, by responding to specific stimuli or environmental cues, enabling achieved various functions at the tumor site, including size‐shrinkage nanocarriers enhance drug penetration, aggregative nanocarriers enhance retention effect, disintegrating nanocarriers enable controlled drug release, and shape‐changing nanocarriers improve cellular uptake, allowing for personalized treatment approaches and combination therapies. This review provides an overview of recent developments and applications of deformable nanocarriers for enhancing tumor therapy, underscores the diverse design strategies employed to create deformable nanocarriers and elucidates their remarkable potential in targeted tumor therapy.

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Influence of amino acids on the aggregation behavior and drug solubilization of branched block copolymers

Cited by 6 publications

References 42 publications

Amino acids induced modulations in linear PEO‐PPO‐PEO triblock copolymer microstructures and its exploration in prototypical drug solubilization

Amino acids induced modulations in linear PEO‐PPO‐PEO triblock copolymer microstructures and its exploration in prototypical drug solubilization

Size control of precipitated particles of amino acids using a bubble column evaporator

Deformable nanocarriers for enhanced drug delivery and cancer therapy

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