Influence of aminoglycoside antibiotics, streptomycin and kanamycin on histamine secretion in mast cells.

Hazama, Setsuro; Kikuchi, Chizuko; Kanno, Morio

doi:10.2131/jts.17.1

Cited by 2 publications

(1 citation statement)

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“…The mechanism by which PPD releases histamine is not certain. It may involve impairment of the cellular events linked to exocytosis (Hazama et al, 1992). Disturbances in cell membrnces leading to cell lysis (Lau and Pearce, 1990), or to opening of certain Ca ion channels leading to elevated intracellular Ca 2+ concentration, which, in turn, may activate mast cell secretion (Eleno et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

Some in vitro and in vivo Pharmacological Observations on Paraphenylene Diamine (Hair Dye)

Saad¹,

Ali²,

Moussa³

et al. 2000

Pakistan J. of Biological Sciences

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Objectives: Paraphenylene diamine (PPD) is commonly used in our region as hair dye, and to itensify Henna color. Several cases of poisoning with this compound have been reported. Therefore, we have examined the actions of PPD on a variety of pharmacological preparations in an attempt to determine the basis of its toxicity. Methods: Several isolated rat, rabbit, frog and Guinea pig preparations were used, together with anesthetized cat for blood pressure measurement. Results: After incubation of PPD with chopped G. Pig lung tissue, the supernatant was found to contract G. Pig illeum. This action was abolished by chlorpheniramine, suggesting that PPD released histamine. PPD, or the chopped lung tissue preparation, given alone, did not contract G. Ileum. Various doses of PPD did not affect striated muscle preparations, nor did it affect isolated tissues preparation, given alone, did not contract G. Ilenum. Various doses of PPD was also without effect on prostaglandin syntheis or receptors. No significant change in blood pressure was observed following PPD injection at low doses in anaesthetized cats, whereas high doses were lethal. Conclusion: PPD was ineffective in significantly altering the reactivity of several pharmacological preparations. It suggested the PPD releases histamine.

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Section: Discussionmentioning

confidence: 99%

Some in vitro and in vivo Pharmacological Observations on Paraphenylene Diamine (Hair Dye)

Saad¹,

Ali²,

Moussa³

et al. 2000

Pakistan J. of Biological Sciences

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Differential Effects of Immunosuppressants and Antibiotics on Human Monoclonal Antibody Production in SCID Mouse Ascites by Five Heterohybridomas

Yoshinari¹,

Arai²

1998

Hybridoma

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SCID mice were inoculated with five human-mouse heterohybridomas derived by fusion of human lymph node lymphocytes from lung cancer patients with murine myeloma cells or human-mouse heteromyeloma cells, and the production of their human monoclonal antibodies (MAb) in the mouse ascites was investigated. In a comparison of the effects of pretreatment by i.p. (intraperitoneal) injection of pristane and anti-asialo GM1 serum on the antibody production of three of the hybridomas, pristane pretreatment resulted in substantial antibody production by all three, and pretreatment with anti-asialo GM1 serum resulted in similar or slightly lower levels of antibody production by two of the hybridomas but none by the third. In a second series of experiments using four of the hybridomas with pristane pretreatment, the co-injection of either penicillin G and streptomycin or kanamycin together with the hybridoma at the time of i.p. inoculation resulted in enhanced MAb production by the two heterohybridomas that had been propagated in medium containing hypoxanthine-aminopterin-thymidine (HAT) but not by the two that had been propagated in HAT-free medium.

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Influence of aminoglycoside antibiotics, streptomycin and kanamycin on histamine secretion in mast cells.

Cited by 2 publications

References 20 publications

Some in vitro and in vivo Pharmacological Observations on Paraphenylene Diamine (Hair Dye)

Some in vitro and in vivo Pharmacological Observations on Paraphenylene Diamine (Hair Dye)

Differential Effects of Immunosuppressants and Antibiotics on Human Monoclonal Antibody Production in SCID Mouse Ascites by Five Heterohybridomas

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