Influence of analgesic active 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one on the antioxidant status, glucose utilization and lipid accumulation in somein vitroandex vivoassays

Abstract

Previously demonstrated antinociceptive properties of LPP1 are accompanied by a lack of cytotoxicity. LPP1 does not impair glucose or lipid metabolism and is an antioxidant. All these properties might be advantageous for its use in diabetic neuropathy.

The anxiolytic-like activity of a novel N-cycloalkyl-N-benzoylpiperazine derivative

“…fipexide) contain a piperazine ring. There 32 are also accumulating data indicating that piperazine derivatives 33 may exhibit other pharmacological activities, such as the 34 anticonvulsant, antinociceptive and antiallodynic activities dem-35 onstrated in animal models, and that they have antioxidant 36 properties, as shown in some in vitro tests [6][7][8][9]. 37 Our previous research was focused on the synthesis and 38 evaluation of biological activities of novel terpenoid derivatives Pharmacological Reports xxx (2015) xxx-xxx Purpose: Anxiety-related disorders are among the most common mental illnesses in the world for which benzodiazepines, buspirone and antidepressant drugs remain the first-line treatment.…”