Influence of Anastomotic Leakage on Oncological Outcome in Patients with Rectal Cancer

Abstract

The rates of anastomotic leakage are reported to range between 0.6% and 17.4%, depending on the definitions used. Here, we review the available information on anastomotic leakage and its association with oncological outcome.

Rectal surgery in octogenarian patients: our experience

“…The incidence of post-operative morbidity and complications are more frequent progressively with advancing age [3-5] but elderly patients with no serious comorbidities had regular post-operative management with no complication as younger people at the same clinical stage, otherwise it is interesting to notice that younger people with metabolic and chronic disease had worse clinical outcome compared to healthy aged patients.…”

Impact of Postoperative Septic Complications on Recurrence of Colorectal Cancer

“…Death of a patient rectal cancer but also seems to be important factor for local reccurence (10). There were reports, indicating 2,5 times higher risk for local reccurence development after anastomotic leakage in rectal cancer resected patients compared with group without leakage (11).…”

Anastomotic Leak and Local Recurrence in Colorectal Cancer

“…[3][4][5] However, it is controversial whether the AL itself is a prognostic factor for local recurrence and/or survival of patients with CRC. Although some investigators report that AL is an independent prognostic factor associated with local recurrence or survival, others do not support this point of view.…”

“…5 One problem with this type of analysis is that usually the proportion of patients with AL is so small that it is difficult to identify it as a factor in long-term survival. 3 Meta-analysis uses statistical methods to obtain a quantitative estimate of the effect of a particular intervention from the effects reported in many studies. Compared with traditional reviews and expert opinion, meta-analysis provides a more objective and quantitative summary of the evidence that is Disclosure: The authors did not receive any financial support or commercial sponsorship.…”

“…9,10 The most important surgical complication following rectal resection with anastomosis is symptomatic AL. [3][4][5]11,12 The incidence of AL varies widely depending on the anastomosis type and the distance from the anal verge. Multiple studies have identified distance from the anal verge to be a substantial risk factor contributing to anastomotic breakdown.…”