In cold regions, saline soils can cause dissolution, settlement, and salt expansion of the roadbed under the influence of freeze–thaw cycles, so they need to be stabilized during road construction. In this study, lime, fly ash (FA), and polyacrylamide (PAM) were used to stabilize sulfate saline soils, and the stabilized saline soils were subjected to the unconfined compressive strength test (UCS), splitting test, and freeze–thaw cycle tests (FTs). The stabilization mechanism of the three materials on saline soils was also studied via scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TG), and X-ray photoelectron spectroscopy (XPS). The test results showed that the addition of lime, FA, and PAM to saline soils can improve the mechanical properties and frost resistance of saline soils. After 28 d of curing, the UCS of FA-, PAM-, and lime-stabilized saline soils increased by at least 55%, 23%, and 1068%, respectively, and the splitting strength increased by at least 161%, 75%, and 2720%, respectively. After five freeze–thaw cycles, the residual strength ratios (BDRs) of the UCS of L2 (lime 8%), F2 (FA 11%), and P2 (PAM 1%) stabilized soils and saline soils were 71.78%, 56.42%, 39.05%, and 17.95%, respectively, and the decreasing trend tended to be stable. The saline soils stabilized by lime and FA were chemically stabilized, and their mechanical properties and frost resistance were better than the physical stabilization of PAM.