“…There are many factors, both external and internal to the body, that may affect the normal biodistribution of radiopharmaceuticals, such as surgical procedures, pathophysiological mechanisms, radiation, infections, smoking (tobacco), use of natural or synthetic drugs and some foods, and nutritional conditions (Barbosa et al, 2009;Bernardo-Filho et al, 2005;Cekic et al, 2011;Holanda et al, 2014;Passos et al, 2002;Valença et al, 2005;Vallabhajosula et al, 2010). Rocha et al (2011), demonstrated that sucralose in different concentrations can change biodistribution of radiopharmaceuticals as sodium pertechnetate in kidney and 99m Tc-DTPA in various organs such as pancreas, stomach, spleen, muscle, and thyroid.…”