Influence of anosognosia on patient-reported outcomes for psychiatric symptoms and quality of life in Huntington's disease

Isaacs, David A.; Hay, Kaitlyn R.; Hoadley, Jennifer; McDonell, Katherine E.; Brown, Amy E.; Wynn, Amy; Claassen, Daniel O.; Gibson, Jessie

doi:10.1016/j.parkreldis.2024.106969

Parkinsonism & Related Disorders

2024

DOI: 10.1016/j.parkreldis.2024.106969

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Influence of anosognosia on patient-reported outcomes for psychiatric symptoms and quality of life in Huntington's disease

David A. Isaacs,

Kaitlyn R. Hay,

Jennifer Hoadley

et al.

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2024

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Cited by 2 publications

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Apathy and Impulsivity Co‐Occur in Huntington's Disease

Morris,

Horne,

Paermentier

et al. 2024

Brain and Behavior

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BackgroundApathy is a debilitating behavioral change in Huntington's disease (HD), but impulsivity in HD has not been well documented, and the co‐occurrence of these behaviors in HD has not been investigated.ObjectiveOur objective was to determine whether apathy and impulsivity co‐occur in people with HD and their associations with quality of life.MethodsCarriers of Huntington's gene expansion (premanifest to mild motor manifest disease; n = 42) along with healthy controls (n = 20) completed measures of apathy (Apathy Evaluation Scale and Apathy Motivation Index) and impulsivity (Barratt Impulsiveness Scale‐11 and UPPS‐P impulsivity scale), along with mood, cognition, clinical, and quality of life measures. Apathy and impulsivity measures were each reduced to a single metric per patient using principal component analysis. Correlations and multiple linear regression models determined associations between apathy and impulsivity and the potential influence of other covariates.ResultsApathy and impulsivity were significantly correlated (r = 0.6, p < 0.001, 95% CI [0.36, 0.76]) in HD, with this association remaining after controlling for depressive symptoms, motor disease severity, and cognitive function. Furthermore, apathy and depressive symptoms were associated with poorer quality of life.ConclusionsApathy and impulsivity co‐occur in individuals with premanifest to mild manifest HD and have a significant impact on wellbeing. We add to a growing evidence body that apathy and impulsivity may be intrinsically linked.

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Apathy and Impulsivity Co‐Occur in Huntington's Disease

Morris,

Horne,

Paermentier

et al. 2024

Brain and Behavior

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Frequency of depression in Huntington's disease: A systematic review and meta-analysis

Zadegan,

Ramirez,

Park

et al. 2024

Journal of Huntington's Disease

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Background Huntington's disease (HD) is a hereditary neurodegenerative disease characterized by a combination of motor, cognitive, and mental health issues, with depression being the most common. Despite its importance, the relationship between depression and disease progression is still debatable. Objective The primary objective of this study was to examine the frequency of depression across different disease stages in individuals with HD. We also explored the associations between depression and other HD-related factors. Methods This systematic review comprehensively searched MEDLINE, APA PsycINFO, and Embase databases for studies on depression in individuals with HD. Pooled depression frequencies were calculated for premanifest and manifest HD. Depression was analyzed based on HD functional stages and diagnostic tools, alongside reviewing its association with various HD factors. Results We assessed 6523 records and included 104 studies. Our meta-analyses revealed that the overall frequency of depression was higher in manifest HD compared to premanifest HD (0.38 vs. 0.23). However, the progression of depression did not follow a consistent pattern, with peaks occurring in earlier rather than later stages. Additionally, the frequency of depression was lower in studies using diagnostic criteria compared to those using clinical scales (0.25 vs. 0.42). Conclusions Our findings showed that the rate of depression is high in HD and varies depending on the disease stage and the criteria used. This emphasizes the necessity for tailored and unified diagnostic criteria for depression in HD.

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Influence of anosognosia on patient-reported outcomes for psychiatric symptoms and quality of life in Huntington's disease

Cited by 2 publications

References 35 publications

Apathy and Impulsivity Co‐Occur in Huntington's Disease

Apathy and Impulsivity Co‐Occur in Huntington's Disease

Frequency of depression in Huntington's disease: A systematic review and meta-analysis

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