Influence of antenatal magnesium sulfate application on cord blood levels of brain-derived neurotrophic factor in premature infants

Bachnas, Muhammad Adrianes; Mose, Johanes C.; Effendi, Jusuf Sulaeman; Andonotopo, Wiku

doi:10.1515/jpm-2013-0137

Cited by 26 publications

(21 citation statements)

References 8 publications

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“…The Alturas have recently demonstrated that short-term magnesium deficiency can down regulate telomerase [62] . In addition to this, Bachnas et al have shown that antenatal supplementation with magnesium sulfate in humans can improve the levels of BDNF [158] . In the setting of experimental menopause, Sandhir et al have found that coenzyme Q10 can ameliorate cognitive functions [159] .…”

Section: Discussionmentioning

confidence: 98%

The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation

Moncayo¹,

Moncayo²

2015

BBA Clinical

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BackgroundThe aim of this study was to discern whether a relation between biochemical parameters, sonography and musculoskeletal data exists in cases of hyperthyroidism and whether they are modifiable through supplementation with selenomethionine and magnesium citrate as well as by acupuncture and manual medicine methods.ResultsA direct correlation between whole blood selenium and serum magnesium was found in subjects without thyroid disease and in menopausal women while it was reversed in cases of thyroid diseases as well as in patients with depression, infection, and in infertile women. Vascularization indices were elevated in cases of newly diagnosed benign thyroid diseases. Musculoskeletal changes i.e. lateral tension and idiopathic moving toes, as well as situations of physical and psychological stress and minor trauma and infection led to an increase of vascularization. Magnesium levels correlated negatively with these two conditions. The supplementation brought a reduction of the vascularization indices and reduced the incidence of idiopathic moving toes. Treatment of lateral tension required manual medicine methods and acupuncture (gastrocnemius). A small subgroup of patients showed a further reduction of hyper-vascularization after receiving coenzyme Q10.ConclusionsWe interpret the elevated thyroid vascularization and low magnesium levels as signs of an inflammatory process related to the musculoskeletal changes. Improvement of thyroid function and morphology can be achieved after correcting the influence of stressors together with the supplementation regime. We hypothesize that the central biochemical event in thyroid disease is that of an acquired, altered mitochondrial function due to deficiency of magnesium, selenium, and coenzyme Q10.

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Section: Discussionmentioning

confidence: 98%

The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation

Moncayo¹,

Moncayo²

2015

BBA Clinical

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“…Magnesium's anti‐inflammatory properties are also observed in vitro in cord blood mononuclear cells of the human neonate . The rate of brain‐derived neurotrophic factor production is correspondingly elevated in the cord blood of infants born preterm whose mothers received magnesium sulphate, which is consistent with an anti‐inflammatory effect . In a murine model of perinatal neuroinflammation, long‐term sex‐specific benefits were observed in magnesium sulphate/betamethasone‐treated cases relative to a placebo group.…”

Section: Mechanisms Involved In the Neuroprotective Effects Of Magnesmentioning

confidence: 76%

“…16 The rate of brain-derived neurotrophic factor production is correspondingly elevated in the cord blood of infants born preterm whose mothers received magnesium sulphate, which is consistent with an anti-inflammatory effect. 17 In a murine model of perinatal neuroinflammation, long-term sex-specific benefits were observed in magnesium sulphate/betamethasone-treated cases relative to a placebo group. The sex-specific effect favoured males; a minimal injury causing a greater alteration to gene control among females, or a heightened susceptibility to magnesium or betamethasone among males, may account for the sex-specific discrepancy.…”

Section: Mechanisms Involved In the Neuroprotective Effects Of Magnesmentioning

confidence: 99%

Protection of brain development by antenatal magnesium sulphate for infants born preterm

Chollat

Sentilhes

Marret

2018

Develop Med Child Neuro

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Cerebral palsy (CP) remains the most significant neurological disorder associated with preterm birth. It disrupts quality of life and places huge cost burdens on society. Antenatal magnesium sulphate administration to females before 32 weeks’ gestation has proven to be an effective intervention to reduce the rate of CP. In models of hypoxia, hypoxia‐ischemia, inflammation, and excitotoxicity in various animal species, magnesium sulphate preconditioning decreased the resulting lesion sizes and inflammatory cytokine levels, prevented cell death, and improved long‐term cognitive and motor behaviours. In humans, meta‐analyses of five randomized controlled trials using magnesium sulphate as a neuroprotectant showed prevention of CP at 2 years. The benefit remained consistent regardless of gestational age, cause of preterm birth, and total dose received. Antenatal magnesium sulphate treatment is now recommended by the World Health Organization and by many obstetric societies. Its cost‐effectiveness further justifies its widespread implementation. What this paper adds Neuroprotective effect of magnesium sulphate to reduce cerebral palsy in infants born preterm when administered to females at risk of imminent preterm birth. Neuroprotection regardless of gestational age, cause of preterm birth, and total dose. Antenatal magnesium sulphate treatment has good cost‐effectiveness.

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“…This theory is supported by several recent papers that demonstrate a suppression of cord blood cytokine production with MgSO 4 use . In 2014, a randomised controlled trial in 72 women showed increased levels of brain‐derived neurotrophic factor (BDNF) in cord blood of preterm babies (born before 34 weeks of gestation) where MgSO 4 (4 g loading dose and 1 g/h until delivery) had been given antenatally, compared with placebo . BDNF is a neurotrophin shown to be protective against neonatal hypoxic‐ischaemic brain injury in vivo .…”

Section: Proposed Mechanism Of Action Of Magnesium Sulfate (Mgso4) Fomentioning

confidence: 90%

Use of magnesium sulfate in preterm deliveries for neuroprotection of the neonate

Usman

Foo

Tay

et al. 2017

The Obstetric & Gynaecologis

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Key content The prevalence of preterm birth is increasing and owing to advances in neonatal care, more infants are surviving. However, in parallel with this, the incidence of cerebral palsy (CP) is also rising. Magnesium sulfate (MgSO4) is currently recommended for use in women who are at risk of giving birth at less than 30–32 weeks of gestation for neuroprotection of their infants. The exact mechanism of action remains unclear. Meta‐analyses report encouraging results that are consistent with a modest but tangible benefit for the use of MgSO4, and suggest a number needed to treat (NNT) to prevent one in 46 cases of CP in infants born preterm before 30 weeks of gestation and one in 63 cases of CP in infants born preterm before 34 weeks of gestation. Learning objectives To gain an understanding of the risk of neurodisability in infants delivered preterm. To become familiar with the main studies assessing the use of MgSO4 for neuroprotection in preterm deliveries. To become aware of the relevant international guidelines. Ethical issues Concerns have been raised regarding the higher number of perinatal deaths reported with the use of MgSO4 in the MagNET study. This was not substantiated in the Cochrane review. Given that MgSO4 is a safe, readily available and inexpensive drug, even if there were only to be modest benefits from its use, the risk–benefit ratio is in favour of its use.

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Influence of antenatal magnesium sulfate application on cord blood levels of brain-derived neurotrophic factor in premature infants

Abstract: The application of antenatal MgSO4 in preterm delivery increased cord blood BDNF levels, which could have a potential role on fetal neuroprotection. Further investigation is needed.

Cited by 26 publications

References 8 publications

The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation

The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation

Protection of brain development by antenatal magnesium sulphate for infants born preterm

Use of magnesium sulfate in preterm deliveries for neuroprotection of the neonate

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