Influence of anti‐allergic drugs used systemically on the process of root resorption during delayed tooth replantation: A study in rats

Abstract

Background/Aim Anti‐allergic drugs can inhibit the hard tissue resorption process, and due to similarities between root resorption and bone mechanisms, it can be inferred that these drugs may also control root resorption. The aim of this study was to analyze the effects of anti‐allergic drugs used systemically on the process of root resorption following delayed tooth replantation. Materials and Methods Thirty‐two maxillary right incisors of rats were extracted and subsequently replanted. Rats were divided into four groups according to the anti‐allergic drug administered: the rats in groups DEX, Q, and MO were treated systemically with dexamethasone phosphate, quercetin, and montelukast, respectively, and no systemic medication was administered to rats in group C. After 60 days, the animals were euthanized, and the specimens were processed for histomorphometric and immunohistochemical analyses. Statistical significance was set at P < .05. Results There were no significant differences between the groups in terms of inflammatory resorption, replacement resorption, or presence of tartrate‐resistant acid phosphatase. In terms of events occurring in the periodontal ligament space, there was a difference between groups Q and MO due to the presence of dental ankylosis and inflammatory connective tissue (P < .05). A difference in inflammatory cells was also observed through CD45 immunolabeling between the DEX and Q groups when compared to the C group (P < .05). Conclusion The systemic administration of anti‐allergic drugs did not have an effect on the process of root resorption following delayed tooth replantation.

Effect of intra‐alveolar delivery of Frondoside A on inflammatory response of delayed tooth replantation

“…A significant difference in levels of CD45 between the control and the FA group were observed in this study. Similarly, in a previous study, the expression of CD45 was also significantly decreased in delayed rat tooth replantation after systemic administration of anti‐allergic drugs 34 . The mechanism of CD45 is mainly known to transduce signal via the MAP kinase pathway to promote transcription factors such as NF‐κB and AP‐1 for T‐cell proliferation and regulation of B‐cell activation 35,36 .…”

“…Similarly, in a previous study, the expression of CD45 was also significantly decreased in delayed rat tooth replantation after systemic administration of anti-allergic drugs. 34 The mechanism of CD45 is mainly known to transduce translocation. 20,37 MMP-9 is one of the key proteases involved in destructive periodontal inflammation and more specifically, resorption and periodontal tissue breakdown.…”