Influence of Anti-Inflammatory Drugs and Free Radical Scavengers on Intestinal Ischemia Induced Oxidative Tissue Damage

Total glutathione is not decreased in infants with necrotizing enterocolitis

“…In experimental intestinal ischemia-reperfusion models of NEC, administration of allopurinol (an inhibitor of xanthine oxidase that is a potent source of ROS) has been shown to reduce tissue damage compared with controls [17]. Similar effects have been observed after administration of other agents that either inhibit ROS production or act as antioxidant compounds such as superoxide dismutase [18], the iron-chelating agent desferrioxamine [18], vitamin E [19], thiopental (a free radical anion scavenger) [20], and the peroxynitrite scavenger iron 5, 10, 15, 20 = Tetrakis (N-methyl-4V-pyridyl) porphyrinato Iron III chloride (Stefanutti, Pierro, and Eaton, unpublished data, 2003).…”

Effects of Piperine in Experimental Intestinal Ischemia Reperfusion Model on Rats

“…Many radical scavengers, interestingly naturally occurring antioxidants, have been found to be effective in inhibiting the induction of lipid peroxidation and ROS. [16][17][18] Studies have also indicated that various spice principles form an important group as antioxidants. [19][20][21] In this study, we investigated whether piperine might have a protective role in an experimental intestinal ischemia-reperfusion model in rats.…”

Multi-Antioxidant Supplementation Does Not Prevent an Increase in Gut Permeability after Lower Torso Ischemia and Reperfusion in Humans

“…There is reason to believe that administration of additional antioxidants can diminish both direct and indirect reperfusion injury [16][17][18][19][20][21][22][23][24][25][26][27].…”