Influence of antiblastic agents applied either in vivo or in vitro on human lymphocyte transformation in cell culture

Astaldi, G; Eridani, S; Ponti, Giovanna; Valentini, Robert F.; Giangrande, A

doi:10.1007/bf01632969

Cited by 11 publications

(3 citation statements)

References 8 publications

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“…The results of our studies in children receiving intensive treatment are clearly different. These observations are in agreement with the few other reports on this subject (Hersh & Oppenheim 1967, Astaldi et al 1969, Lopes Cardozo 1970. They also observed a striking decrease of PHA stimulation after intensive cytostatic therapy.…”

Section: Discussionsupporting

confidence: 93%

Phytohaemagglutinin Stimulation of Peripheral Lymphocytes in Children with Acute Lymphoblastic Leukaemia during Remission

Bakkeren

Vaan

Schretlen

1972

Scandinavian Journal of Haematology

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PHA response in vitro of peripheral blood lymphocytes from patients with ALL was determined during remission by 3H‐thymidine uptake. Short courses of intensive treatment with rubidomycin, vincristine, and prednisone significantly diminished both the PHA response and the number of circulating lymphocytes. PHA stimulation restored itself rather quickly after the cytostatic treatment. Maintenance therapy with 6‐mercaptopurine, methotrexate, or cyclophosphamide did not cause a significant change in PHA response. The results are discussed in relation to the immunological status of the patients and the possibilities of active immunotherapy.

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Section: Discussionsupporting

confidence: 93%

Phytohaemagglutinin Stimulation of Peripheral Lymphocytes in Children with Acute Lymphoblastic Leukaemia during Remission

Bakkeren

Vaan

Schretlen

1972

Scandinavian Journal of Haematology

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“…the antibody-formation on the cellular level [19] and the graft reaction [9,10,13,17]. I t could be demonstrated that immunological function of lymphocytes can be suppressed by cytostatic drugs [2,4,11,14]. But the results of the present experiments indicate that cytostatic drugs are inhibitory on immunocompetent cells only when administered in very high doses.…”

Section: Discussionmentioning

confidence: 53%

Effect of cytostatic drugs on blast cell transformation of lymph node and spleen cells

Scheiffarth

Warnatz

et al. 1973

Res. Exp. Med.

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Summary. Different groups of NMRI-mice were given single doses of 2, 10, 50, 250 or 1000 mg/kg of Cph or 6-~IP. Other groups were applicated 7 x 10 mg/kg every alternate day. 2 days after the last dose lymph node and spleen cells were collected and stimulated with PHA. Stimulation was estimated by the quotient of the uptake of att-thymidine in stimulated and unstimulated cultures. Controls were untreated animals. It could be demonstrated that only maximal doses could inhibit the stimulation. Cph was more efficient than 6-MP. Lymph node cells were more sensitive than spleen cells. Repeated application showed no effect.The results demonstrate that cytostatie drugs can inhibit blast cell transformation in vivo. The different results are due to the different mode of action of those substances and from the different populations of harvested cells.

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“…Es handelt sich dabei u.a. um Hormone [31,32], Stoffwechsclinhibitoren [23,33,41,42,44], Zytostatika [3,20], Makromoleküle [5,13,37], Viren [28,50,53], Extrakte aus Mykoplasmen [14], Ouabain, Adamantinhydrochlorid und Natriumsalizylat [39,43,45]. Sämtliche dieser Möglichkeiten sind von grossem Interesse, da sie u.U.…”

Section: Gewebekulturmethodenunclassified

Wirkung von L-Asparaginase aus <i>Escherichia col</i><i>i</i> auf die Stimulation von Lymphozytenkulturen

Kirchner¹,

Bauer²

1970

Acta Haematol

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Influence of antiblastic agents applied either in vivo or in vitro on human lymphocyte transformation in cell culture

Cited by 11 publications

References 8 publications

Phytohaemagglutinin Stimulation of Peripheral Lymphocytes in Children with Acute Lymphoblastic Leukaemia during Remission

Phytohaemagglutinin Stimulation of Peripheral Lymphocytes in Children with Acute Lymphoblastic Leukaemia during Remission

Effect of cytostatic drugs on blast cell transformation of lymph node and spleen cells

Wirkung von L-Asparaginase aus <i>Escherichia col</i><i>i</i> auf die Stimulation von Lymphozytenkulturen

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