Influence of autogenous platelet concentrate on combined GTR/graft therapy in intra‐bony defects: A 13‐year follow‐up of a randomized controlled clinical split‐mouth study

Abstract

Within the limits of this study, the data show that most of the CAL gain following GTR can be maintained over 13 years. The additional use of APC had no positive influence on the long-term stability.

Tooth survival and clinical outcomes up to 26 years after guided tissue regeneration therapy in deep intra‐bony defects: Follow‐up investigation of three randomized clinical trials

“…The median V-rAG was found 66.7% (in situ) and 60.0% (extracted) between baseline and 1 year, and 57.1% in the in situ-group between baseline and the follow-up after up to 26 years.4 | D ISCUSS I ONThere are only very few studies reporting on long-term outcomes after regenerative periodontal therapies, as it was recently concluded byWu et al (2017) in their systematic review. With regard to GTR (or combined GTR/graft therapy) in intra-bony defects, there are only five studies with follow-up periods of 10 years (Nickles, Ratka-Krüger, Neukranz, Raetzke, & Eickholz, 2009; Nygaard-Østby, Bakke, Nesdal, Susin, & Wikesjö, 2010; Pretzl, Kim, Holle,& Eickholz, 2008;Pretzl et al, 2009;Sculean et al, 2008), one study with 13-year follow-up evaluating additional application of autogenous platelet concentrate(Cieplik et al, 2018) and two studies with follow-up periods of 20 years(Cortellini et al, 2017;Petsos et al, 2019). These latter two studies are prospective clinical studies comparing GTR therapy and open flap debridement (OFD) but comprise only 41 defects (in 41 patients; parallel design;Cortellini et al, 2017) or 38 defects (in 12 patients; split-mouth design;Petsos et al, 2019), respectively.…”

Tooth preservation vs. extraction and implant placement in periodontally compromised patients: A systematic review and analysis of studies

“…These included scaling and root planning, 97,98 osseous surgery, 97,98 flap surgery combined with laser conditioning, 98 and for the majority of the cases, regenerative techniques, using a wide variety of biomaterials. 8,[60][61][62]64,[99][100][101][102][103][104]107,109,110,112,115 An interesting finding is that, in all but 1 study in the tooth retention group, there was a CAL gain and PD mean values improved with time. Only Orsini et al reported a slight increase in PD mean values in the follow-up examination compared to the baseline.…”

“…After discussion and further evaluation between the authors another 35 full-text articles were excluded and not analyzed further (Table 1). 1,[19][20][21] Twenty studies reporting on tooth preservation and periodontal treatment or regeneration 8,9,[60][61][62][63][64][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112][113][114] and 3 studies reporting on tooth extraction followed by implant placement were finally selected for inclusion in the present review. 22,113,114 These were 11 RCTs and 13 prospective studies.…”

“…116 More than half of the tooth retention studies (65%) were conducted in an academic setting. 8,61,62,[98][99][100][101][102]104,106,[107][108][109]111,113 On the contrary, in the majority of implant placement studies (66.66%), treatment took place in a private practice. 22,113 This fact presents a potential limitation regarding the conclusions that can be drawn.…”

“…6,7 Stages III and IV periodontitis indicate advanced clinical attachment loss (CAL ≥ 5 mm), deep periodontal pockets (PD ≥ 6mm), Class II or III root furcation involvement and radiographic bone loss (≥50%). 2,[8][9][10] In addition to diagnosis, the above data contribute to the assignment of a prognostic status of individual teeth that will be reflected in the proposed treatment plan. 11 Various prognostic models have been proposed to establish the reliability of a tooth for further treatment, and to develop the restorative treatment plan.…”