Influence of Axial Involvement on Clinical Characteristics of Psoriatic Arthritis: Analysis from the Corrona Psoriatic Arthritis/Spondyloarthritis Registry

Mease, Philip J.; Palmer, Jacqueline B.; Liu, Mei; Kavanaugh, Arthur; Pandurengan, Renganayaki; Ritchlin, Christopher T.; Karki, Chitra; Greenberg, Jeffrey D.

doi:10.3899/jrheum.171094

Cited by 108 publications

(111 citation statements)

References 38 publications

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“…Furthermore, PsA is a systemic disease that affects many joints, including axial joints. A previous study showed that the presence of axial involvement was associated with higher disease activity, including CRP and VAS 29 . Hence, results of the blood samples may not completely reflect the state of joints in the hand and foot.…”

Section: Inter-reader Reliabilitymentioning

confidence: 91%

Quantitative analysis of therapeutic response in psoriatic arthritis of digital joints with Dual-energy CT iodine maps

Kayama

Fukuda

Ogiwara

et al. 2020

Sci Rep

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the aim of this study was to investigate the feasibility of quantitative assessment of the therapeutic response in psoriatic arthritis (psA) by measuring iodine uptake using a Dual-energy ct (Dect) iodine map. The study included 74 symptomatic and 74 matching non-symptomatic joints of 26 consecutive psA patients who underwent two contrast enhanced Dects of the hand or foot, pre and post medical interventions. Symptomatic and matched non-symptomatic control joints were scored with the psA Dect Scoring System (psADectS), which was derived by modifying the psA MRi Scoring System (PsAMRIS), a recently validated scoring system that assesses PsA changes on MRI. Quantified iodine uptake measured using the DECT iodine map was compared to the PsADECTS score. Efficacy of PsA treatment was confirmed by the improved clinical findings. Both PsADECTS and iodine uptake also showed significant improvement after treatment (Wilcoxon signed-rank test: z = 7.38, p < 0.005; z = 6.20, p < 0.005, respectively). The treatment effects of PsADECTS score and iodine uptake showed a good correlation with each other (Spearman's ρ = 0.58 p < 0.005). Inter-reader agreement for psADectS score and iodine uptake were either moderate or good. in conclusion, our study showed that the Dect iodine map is a valid tool for quantitative assessment of the therapeutic response of psA.

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Section: Inter-reader Reliabilitymentioning

confidence: 91%

Quantitative analysis of therapeutic response in psoriatic arthritis of digital joints with Dual-energy CT iodine maps

Kayama

Fukuda

Ogiwara

et al. 2020

Sci Rep

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“…In treating PsA patients, we should consider the considerable percentage of PsA patients having axial involvement and choose the right biologic agent. Mease et al found the clinical characteristics of 192 PsA patients with axial involvement by comparing them with 1338 PsA patients without it [48]. Axial involvement was defined as physician-reported presence of spinal involvement at enrollment, and/or radiograph or MRI showing sacroiliitis.…”

Section: Psoriatic Arthritismentioning

confidence: 99%

Efficacy and Safety of Biologics for Psoriasis and Psoriatic Arthritis and Their Impact on Comorbidities: A Literature Review

Kamata

Tada

2020

IJMS

163

116

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Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema. It impairs patients’ quality of life enormously. It has been recognized not only as a skin disease but as a systemic disease, since it also causes arthritis (psoriatic arthritis) and mental disorders. Furthermore, an association with cardiovascular events is indicated. With the advent of biologics, treatment of psoriasis dramatically changed due to its high efficacy and tolerable safety. A variety of biologic agents are available for the treatment of psoriasis nowadays. However, characteristics such as rapidity of onset, long-term efficacy, safety profile, and effects on comorbidities are different. Better understanding of those characteristic leads to the right choice for individual patients, resulting in higher persistence, longer drug survival, higher patient satisfaction, and minimizing the disease impact of psoriasis. In this paper, we focus on the efficacy and safety profile of biologics in psoriasis patients, including plaque psoriasis and psoriatic arthritis. In addition, we discuss the impact of biologics on comorbidities caused by psoriasis.

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“…Между тем своевременная диагностика спондилита крайне важна, поскольку поражение позвоночника рассматривается как фактор неблагоприятного прогноза ПсА, который существенно влияет на выбор лечения, в том числе ГИБП. По данным ряда крупных наблюдательных исследований, спондилит чаще выявляется у носителей HLA-B27-антигена и ассоциируется с развитием эрозивного артрита, энтезита и более тяжелого псориаза ногтей по индексу NAPSI (Nail Psoriasis Severity Index [23,24]. Однако авторы этих работ отмечают, что позитивность по HLA-B27-антигену не может быть облигатным признаком развития спондилита при ПсА, так как частота его при этом заболевании составляет 40-50%.…”

Section: клинические проявления псаunclassified

Detectability of the peripheral and axial manifestations of psoriatic arthritis in patients with psoriasis in dermatological practice

Chamurlieva¹,

Логинова²,

Коротаева³

2019

Sovremennaâ revmatologiâ

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Psoriatic arthritis (PsA) is a heterogeneous disease manifested by peripheral arthritis, dactylitis, spondylitis, and enthesitis. PsA is often undiagnosed by dermatovenerologists because of the difficulty in identifying a variety of clinical signs. The early diagnosis of PsA and the accurate assessment of all its symptoms are necessary for the timely choice of optimal therapy.Objective: to assess the detectability of clinical signs of PsA in patients with psoriasis in dermatological practice.Patients and methods. The investigation enrolled 103 patients (47 men and 56 women) (mean age, 44.0±13.7 years) with psoriasis (its mean duration, 10.7±10.2 years), the average prevalence and severity according to the Body Surface Area (BSA) and the Psoriasis Area and Severity Index (PASI) were 9.3±13.6% and 15.4±12.5 scores, respectively. All the patients completed the Psoriasis Epidemiology Screening Tool (mPEST) and were examined by a dermatovenerologist and a rheumatologist. The diagnosis of PsA was based on the Classification Criteria for Psoriatic Arthritis (CASPAR). The investigators evaluated arthritis, dactylitis, enthesitis, and inflammatory back pain (IBP) according to the rheumatological standards: IBP by the Assessment of SpondyloArthritis International Society (ASAS) criteria, and enthesitis by the Leeds Enthesitis Index (LEI).Results and discussion. Sixty-one (59.2%) of the 103 patients with psoriasis were found to have PsA on the basis of the CASPAR criteria and the rheumatologist's examination. The dermatovenerologist diagnosed arthritis in a significantly smaller number of cases than did the rheumatologist: in 15 (24.6%) and 35 (57.4%) of the 61 patients (p<0.001), respectively. The dermatovenerologist and the rheumatologist demonstrated no significant differences in their clinical evaluation of dactylitis: it was detected in 37 (60.7%) and 40 (65.6%) of the 61 patients, respectively (p=0.32). Based on patient complaints and mPEST findings, the dermatovenerologist recorded pain in the calcaneal region in 32 (52.5%) patients. The rheumatologist identified ulnar, knee, and calcaneus enthesitis in 11 (18%), 8 (13.1%), and 25 (41%) patients, respectively. Based on complaints and mPEST findings, the dermatovenerologist detected back pain in 30 (49.2%) of the 61 patients. The rheumatologist diagnosed IBP in 21 (70%) of these 30 patients and mechanical back pain in 9 (30%). Thus, IBP was noted in 34.4% of PsA patients. Tendonitis was undiagnosed by the dermatovenerologist; the rheumatologist identified wrist tendonitis in 13 (21.3%) of the 61 patients with PsA.Conclusion. Dermatovenerologists frequently underestimate damage to the spine and entheses in patients with psoriasis. The introduction of the ASAS criteria for IBP and methods for assessing enthesitis in dermatological practice can improve the early diagnosis of axial lesion in PsA in patients with psoriasis.

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Influence of Axial Involvement on Clinical Characteristics of Psoriatic Arthritis: Analysis from the Corrona Psoriatic Arthritis/Spondyloarthritis Registry

Abstract: Presence of axial involvement was associated with a higher likelihood of moderate/severe psoriasis, with higher disease activity and greater effect on quality of life. These findings highlight the importance of monitoring patients with PsA for signs of axial symptoms or spinal involvement.

Cited by 108 publications

References 38 publications

Quantitative analysis of therapeutic response in psoriatic arthritis of digital joints with Dual-energy CT iodine maps

Quantitative analysis of therapeutic response in psoriatic arthritis of digital joints with Dual-energy CT iodine maps

Efficacy and Safety of Biologics for Psoriasis and Psoriatic Arthritis and Their Impact on Comorbidities: A Literature Review

Detectability of the peripheral and axial manifestations of psoriatic arthritis in patients with psoriasis in dermatological practice

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