Influence of azathioprine on hepatic reserve in chronic active liver disease.

Rikkers, Layton F.; Sherlock, Sheila

doi:10.1136/gut.16.3.214

Cited by 10 publications

(1 citation statement)

References 14 publications

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“…In contrast, no effect was seen in two patients treated with azathioprine, which acts predominantly as an immunosuppressant. This is in agreement with previous studies with indocyanine green which showed no improvement in hepatic reserve (Rikkers and Sherlock, 1975).…”

Section: Discussionsupporting

confidence: 94%

Assessment of the (14C) aminopyrine breath test in liver disease.

Galizzi¹,

Long²,

Billing³

et al. 1978

Gut

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SUMMARY Different methods of performing the (14C) aminopyrine breath test have been assessed.A tracer dose of 2 ,uCi without a loading dose and with a single breath collection at two hours was the method selected, since it gave the best discrimination between patients with hepatocellular diseases and normal subjects (5-2 + 0-2%, mean + SEM). Reduced values occurred in patients with chronic active hepatitis (with and without cirrhosis) (1-5 + 0 2%), alcoholic cirrhosis (1'7 + 0 4 %) and hepatitis (2-5 ± 0 3 %), and late primary biliary cirrhosis suggesting defective microsomal function with respect to demethylation. Normal results were common in early primary biliary cirrhosis. Two weeks of prednisolone therapy caused some improvement in the breath test in nine of 10 patients with chronic active hepatitis. It is concluded that the (14C) aminopyrine breath test is a simple test for detecting hepatocellular dysfunction, but has no obvious diagnostic advantage over the determination of serum aspartate transaminase and two hour post-prandial bile-acids.

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Section: Discussionsupporting

confidence: 94%