Influence of BDNF Val66Met on the relationship between cardiorespiratory fitness and memory in cognitively normal older adults

Brown, Belinda M.; Castalanelli, Natalie; Rainey-Smith, Stephanie R.; Doecke, James D.; Weinborn, Michael; Sohrabi, Hamid R.; Martins, Ralph N.; Peiffer, Jeremiah J.

doi:10.1016/j.bbr.2019.01.013

Cited by 11 publications

(12 citation statements)

References 37 publications

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“…Further, when examined across the entire sample, Dougherty et al (2017) [28] demonstrated no overall statistically significant association between CRF and memory, but CRF was positively and statistically significantly associated with memory among men. Lastly, Brown et al (2019) [26] did not observe an association between CRF and verbal memory but did observe a statistically significant positive association between CRF and paired associative memory.…”

Section: Resultsmentioning

confidence: 99%

“…Among the 15 cross-sectional studies [19,20,21,22,23,26,27,28,29,30,31,32,33,34,35], 13 demonstrated a statistically significant positive association between CRF and memory function, whereas two studies [30,32] demonstrated no statistically significant association between CRF and memory. Thus, the majority of these cross-sectional studies (86.7%; 13/15) demonstrated a positive relationship between CRF and memory.…”

Section: Resultsmentioning

confidence: 99%

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The Association of Cardiorespiratory Fitness on Memory Function: Systematic Review

Rigdon

Loprinzi

2019

Medicina

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Background and Objectives: Cardiorespiratory fitness is an important predictor of cardiovascular and cardiometabolic health. To extend our knowledge on the health effects associated with cardiorespiratory fitness, the objective of this study was to evaluate the association of cardiorespiratory fitness on memory function. Materials and Methods: Embase/PubMed, Web of Science, Google Scholar, Sports Discus, and PsychInfo databases were searched. Inclusionary criteria included: (1) were conducted among adult humans (18+ years), (2) evaluated cardiorespiratory fitness as the independent variable, (3) measured cardiorespiratory fitness with an objective device (e.g., indirect calorimetry), (4) evaluated memory function (any type) as the outcome measure, and (5) included either a cross-sectional, prospective, or experimental-study design. Information on the participant’s characteristics, study design, cardiorespiratory fitness assessment, memory type, whether the study statistically controlled for exercise behavior, and study results were extracted. The relationship between cardiorespiratory fitness and memory was synthesized while considering the data extraction parameters. Results: In total, 17 articles met the inclusionary criteria, including two prospective cohort studies and 15 cross-sectional studies. The main findings of this review are twofold: (1) across the 17 evaluated studies, 15 (88.2%) studies demonstrated some evidence of a positive association between cardiorespiratory fitness (CRF) and memory function, and (2) none of these 17 studies statistically controlled for physical activity behavior. Conclusion: CRF appears to be positively associated with memory function, however, it is uncertain as to whether this association occurs independently of physical activity or is mediated via physical activity behavior.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Association of Cardiorespiratory Fitness on Memory Function: Systematic Review

Rigdon

Loprinzi

2019

Medicina

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“…Nevertheless, the direction of the effect of Val66Met in those nine studies was inconsistent and only reached statistical significance in a small number of cognitive tests, which reinforces the possibility that some aspects of cognition are more susceptible than others to the modulatory effects of this polymorphism (Toh and others 2018). When only Val carriers were compared, four studies showed that high levels of PA were associated with better performance in memory (Canivet and others 2015; Watts and others 2018) and executive function (Canivet and others 2017; Thibeau and others 2016; Watts and others 2018), while one study found no association with memory (Brown and others 2019). When only Met carriers were compared, two studies showed that higher PA levels were associated with better performance in memory (Brown and others 2019) and global cognition (Pitts and others 2020), while two studies showed no influence of PA level in memory (Canivet and others 2015) or executive function (Thibeau and others 2016).…”

Section: The Moderating Effect Of Val66met In Observational Studiesmentioning

confidence: 99%

Does the Brain-Derived Neurotrophic Factor Val66Met Polymorphism Modulate the Effects of Physical Activity and Exercise on Cognition?

et al. 2020

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The Val66Met is a polymorphism of the brain-derived neurotrophic factor (BDNF) gene that encodes a substitution of a valine (Val) to methionine (Met) amino acid. Carrying this polymorphism reduces the activity-dependent secretion of the BDNF protein, which can potentially affect brain plasticity and cognition. We reviewed the biology of Val66Met and surveyed 26 studies (11,417 participants) that examined the role of this polymorphism in moderating the cognitive response to physical activity (PA) and exercise. Nine observational studies confirmed a moderating effect of Val66Met on the cognitive response to PA but differences between Val and Met carriers were inconsistent and only significant in some cognitive domains. Only five interventional studies found a moderating effect of Val66Met on the cognitive response to exercise, which was also inconsistent in its direction. Two studies showed a superior cognitive response in Val carriers and three studies showed a better response in Met carriers. These results do not support a general and consistent effect of Val66Met in moderating the cognitive response to PA or exercise. Both Val and Met carriers can improve specific aspects of cognition by increasing PA and engaging in exercise. Causes for discrepancies among studies, effect moderators, and future directions are discussed.

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“…Among these factors, it has been shown that a considerable amount (approximately up to half of the variance) of the interindividual heterogeneity in physical outcomes (Bouchard and Rankinen, 2001; Timmons et al, 2010; Davidsen et al, 2011; Timmons, 2011; Bouchard, 2012; Wilson et al, 2019), cognitive outcomes (McClearn, 1997; Goldberg and Weinberger, 2004; Blokland et al, 2008; Erickson et al, 2008; Friedman et al, 2008; Canivet et al, 2015, 2017), and brain structure outcomes (Thompson et al, 2001; Toga and Thompson, 2005; Bueller et al, 2006) are explained by genetics. However, considering current evidence, lifestyle factors may equalize a “genetic handicap” since people with a high CRF level but “unfavorable” genetic polymorphisms do not need to perform significantly poorer than individuals with low CRF level but “favorable” genetic equipment (Brown et al, 2019). These findings suggest that a genetic handicap can be counteracted by other factors (Flück, 2018) and that “overemphasizing” genetics for the individualization of exercise prescriptions is counter-productive (Carlsten and Burke, 2006; Kohane, 2009; Horwitz et al, 2013; Joyner and Lundby, 2018; Peck, 2018; Joyner, 2019).…”

Section: Introductionmentioning

confidence: 99%

Dose–Response Matters! – A Perspective on the Exercise Prescription in Exercise–Cognition Research

et al. 2019

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In general, it is well recognized that both acute physical exercises and regular physical training influence brain plasticity and cognitive functions positively. However, growing evidence shows that the same physical exercises induce very heterogeneous outcomes across individuals. In an attempt to better understand this interindividual heterogeneity in response to acute and regular physical exercising, most research, so far, has focused on non-modifiable factors such as sex and different genotypes, while relatively little attention has been paid to exercise prescription as a modifiable factor. With an adapted exercise prescription, dosage can be made comparable across individuals, a procedure that is necessary to better understand the dose–response relationship in exercise–cognition research. This improved understanding of dose–response relationships could help to design more efficient physical training approaches against, for instance, cognitive decline.

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Influence of BDNF Val66Met on the relationship between cardiorespiratory fitness and memory in cognitively normal older adults

Cited by 11 publications

References 37 publications

The Association of Cardiorespiratory Fitness on Memory Function: Systematic Review

The Association of Cardiorespiratory Fitness on Memory Function: Systematic Review

Does the Brain-Derived Neurotrophic Factor Val66Met Polymorphism Modulate the Effects of Physical Activity and Exercise on Cognition?

Dose–Response Matters! – A Perspective on the Exercise Prescription in Exercise–Cognition Research

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