Influence of beta-blocker therapy on antitachycardia pacing effectiveness for monomorphic ventricular tachycardias occurring in implantable cardioverter-defibrillator patients: a dose-dependent effect

Abstract

Beta-blockers increase the effectiveness of ATP through a dose-dependent effect. As a result, they reduce the incidence of shocks due to VT.

Influence of cycle length variations on antitachycardia pacing effectiveness among ICD patients

“…3,20,23 In the present study, the rate of VT-related symptoms was similar to others reported previously. 3,24 However, episodes with lower degrees of R-R fluctuations and/or progressive acceleration had a higher incidence of syncope or near syncope because they were associated with a lower ATP effectiveness.…”

Safety and efficacy of anti‐tachycardia pacing in patients with hypertrophic cardiomyopathy implanted with an ICD

“…In our study population, VT cycle length, ATP pacing rate, cycle length variability, and EGM‐morphology did not predict ATP efficacy. In agreement with previous reports, beta‐blockers improved the success rate of ATP. Indeed, beta‐blockers prolong the excitable gap, thereby facilitating ATP to enter in the VT circuit …”

Antitachycardia pacing for reduction of implantable cardioverter-defibrillator shocks

“…19 Blockade of beta-adrenergic receptors has consequently been shown to increase ATP efficacy. 20 Pacing stimulus for ATP delivery is conventionally expressed as a percentage of the tachycardia cycle length for a given R-R interval from 0 to 100 from the onset of the preceding R wave. Pace stimulation delivered at shorter coupling intervals (ie, o85%) may be more likely to enter the circuit but also accelerate the arrhythmia 21 unless delivered in a shortened train of 5 pulses.…”