Influence of between‐limb asymmetry in muscle mass, strength, and power on functional capacity in healthy older adults

Mertz, Kenneth; Reitelseder, Søren; Jensen, Mikkel; Lindberg, Jonas; Hjulmand, Morten; Schucany, Aide; Andersen, Søren Binder; Bechshoeft, Rasmus; Jakobsen, Markus Due; Bieler, Theresa; Beyer, Nina; Nielsen, Jakob Lindberg; Aagaard, Per; Holm, Lars

doi:10.1111/sms.13524

Cited by 34 publications

(37 citation statements)

References 42 publications

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“…The test was performed in a Kinetic Communicator (Kin‐Com, model 500‐11, Kinetic Communicator, Chattecx, Chattanooga, TN), as described previously by Aagaard et al (2001) . The test‐protocol followed standard routines in our lab (for detailed description see Mertz et al). Strong verbal encouragement was provided before and during each contraction and visual feedback were given in terms of force curves displaying the best attempt together with the latest attempt on a computer screen.…”

Section: Methodsmentioning

confidence: 99%

Preserved capacity for satellite cell proliferation, regeneration, and hypertrophy in the skeletal muscle of healthy elderly men

et al. 2020

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Blunted muscle hypertrophy and impaired regeneration with aging have been partly attributed to satellite cell (SC) dysfunction. However, true muscle regeneration has not yet been studied in elderly individuals. To investigate this, muscle injury was induced by 200 electrically stimulated (ES) eccentric contractions of the vastus lateralis (VL) of one leg in seven young (20-31 years) and 19 elderly men (60-73 years).This was followed by 13 weeks of resistance training (RT) for both legs to investigate the capacity for hypertrophy. Muscle biopsies were collected Pre-and Post-RT, and 9 days after ES, for immunohistochemistry and RT-PCR. Hypertrophy was assessed by MRI, DEXA, and immunohistochemistry. Overall, surprisingly comparable responses were observed between the young and elderly. Nine days after ES, Pax7+ SC number had doubled (P < .05), alongside necrosis and substantial changes in expression of genes related to matrix, myogenesis, and innervation (P < .05). Post-RT, VL cross-sectional area had increased in both legs (~15%, P < .05) and SCs/type II fiber had increased ~2-4 times more with ES+RT vs RT alone (P < .001). Together these novel findings demonstrate "youthful" regeneration and hypertrophy responses in human elderly muscle. Furthermore, boosting SC availability in healthy elderly men does not enhance the subsequent muscle hypertrophy response to RT. K E Y W O R D S heavy resistance training, human, myofiber necrosis, myogenic progenitor cells, in vivo myogenesis, Sarcopenia | 6419 KARLSEN Et AL. F I G U R E 1 Study design. Overview of the study design indicating the timing of muscle biopsies, blood sampling, electrical stimulation (ES), measures of muscle soreness, maximal muscle strength (MVC), magnetic resonance imaging (MRI), dual energy X-ray absorptiometry (DXA), and resistance training (RT) during the Pre-and Post-test. One leg (ES+RT leg) completed 200 electrically stimulated eccentric contractions (ES) followed by 13 weeks resistance training (RT), the other leg performed RT only. A biopsy was collected in both legs at Pre and Post, and an additional biopsy was collected in the ES+RT leg at Day 9 after ES | 6421 KARLSEN Et AL.

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Section: Methodsmentioning

confidence: 99%

Preserved capacity for satellite cell proliferation, regeneration, and hypertrophy in the skeletal muscle of healthy elderly men

et al. 2020

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“…The functional capacities of the participants were assessed by applied functional measures and strength measures. Detailed methods for these measurements can be found elsewhere [ 43 , 50 ]. The strength measures included: the dominant hand grip strength using a grip strength dynamometer (DHD-1 (SH1001); SAEHAN Corporation, Changwon City, Korea), Maximal Voluntary isometric Contraction (MVC) of the dominant m. quadricep muscle strength, measured at 70-degree flexion in a Kinetic Communicator (model 500-11, Kinetic Communicator; Isokinetic International, Chattanooga, TN, USA).…”

Section: Methodsmentioning

confidence: 99%

“…The functional capacities of the participants were assessed by applied functional measures and strength measures. Detailed methods for these measurements can be found elsewhere [43,50]…”

Section: Muscle Strength and Functional Capabilitymentioning

confidence: 99%

“…The association between the protein distribution for participants with a lower protein intake (n = 25, 12 men and 13 women) and a higher protein intake (n = 98,50 men and 48 women (n = 47 for Maximal Voluntary isometric Contraction (MVC) due to one missing value)) and Appendicular distribution (%) WOMEN (r = -0.39, P = 0.19) MEN (r = 0.13, P = 0.68) distribution (%) WOMEN (r = -0.20, P = 0.18) MEN (r = -0.053, P = 0.71)…”

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confidence: 99%

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Daily Protein and Energy Intake Are Not Associated with Muscle Mass and Physical Function in Healthy Older Individuals—A Cross-Sectional Study

et al. 2020

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Dietary protein has a pivotal role in muscle mass maintenance with advancing age. However, an optimal dose and distribution of protein intake across the day as well as the interaction with energy intake for the maintenance of muscle mass and physical function in healthy older adults remain to be fully elucidated. The purpose of this study was to examine the association between muscle mass, strength, and physical function, and the total amount and distribution of protein and energy intake across the day in healthy older individuals. The research question was addressed in a cross-sectional study including 184 Danish men and woman (age: 70.2 ± 3.9 years, body mass: 74.9 ± 12.1 kg, Body Mass Index (BMI): 25.4 ± 3.7 kg/m2) where a 3-day dietary registration, muscle mass, strength, and functional measurements were collected. We found that neither daily total protein intake nor distribution throughout the day were associated with muscle mass, strength, or physical function. Consequently, we do not provide an incentive for healthy older Danish individuals who already adhere to the current internationally accepted recommended dietary protein intake (0.83 g/kg/day) to change dietary protein intake or its distribution pattern throughout the day.

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“…In the control group, a significant side-to-side difference was found for the hip adduction with an average deficit of 0.1 N m/kg (8%) on the non-dominant side. Side-to-side strength imbalances of the lower extremities have been reported to not only exist for injured athletes but also in asymptomatic healthy individuals [38][39][40]. The side differences of strength might differ for each joint and functional task as well as might be influenced by age [39].…”

Section: Discussionmentioning

confidence: 99%

Inter-limb differences in total hip arthroplasty patients four to five years after surgery: a cross-sectional study

John¹,

Weizel²,

Heumann³

et al. 2020

Preprint

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BackgroundːTotal hip arthroplasty (THA) is a successful method to reduce pain in end-stage hip osteoarthritis (OA) patients. If the pre-operatively existing deficits in the affected limb are persisting years after THA has not been thoroughly researched. Therefore, the aim of the study was to investigate potential side-to-side differences in long-time THA patients.MethodsːSixteen patients (age: 65.20 ± 5.32 years), who had undergone unilateral THA four to five years ago and ten, healthy, age-matched controls (age = 60.85 ± 7.57 years) were examined for maximum isometric hip muscle strength, range of motion (ROM) of the hip joint, balance and gait on both limbs. Paired t-testes were used to assess the inter-limb differences in THA patients and controls and unpaired t-tests were applied to investigate differences between the two groups.ResultsːIn THA patients, significant deficits on the operated side were found for the center of pressure (COP) length, hip abduction torque and ROM of hip extension with small to medium effects. Compared to the controls, THA patients demonstrated highly significantly reduced hip strength in flexion, extension, abduction and adduction as well as limited ROM in hip flexion and abduction.ConclusionsːA few side-to-side difference were present in THA patients four to five years after the surgery, although the general hip muscle weakness and restricted hip ROM compared to the controls was more severe. Postoperative training focusing on strengthening hip muscles should be continued months and years after the surgery in order to compensate persisting deficits.Trial registrationːDRKS, DRKS00016945. Registered 12 March 2019 – Retrospectively registered, http://www.drks.de/DRKS00016945

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Influence of between‐limb asymmetry in muscle mass, strength, and power on functional capacity in healthy older adults

Cited by 34 publications

References 42 publications

Preserved capacity for satellite cell proliferation, regeneration, and hypertrophy in the skeletal muscle of healthy elderly men

Preserved capacity for satellite cell proliferation, regeneration, and hypertrophy in the skeletal muscle of healthy elderly men

Daily Protein and Energy Intake Are Not Associated with Muscle Mass and Physical Function in Healthy Older Individuals—A Cross-Sectional Study

Inter-limb differences in total hip arthroplasty patients four to five years after surgery: a cross-sectional study

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