Influence of Binder Type on Interacting Variables Acting on Mechanical Properties of a Sulfadimidine Tablet Formulation

Abstract

A study of the quantitative effect of type of binder (N), applied pressure (P), and granular size (G) on two mechanical properties-tensile strength (TS) and brittle fracture index (BFI) - of a sulfadimidine tablet formulation has been carried out by using a 2(3) factorial experimental design. The results obtained from this work suggest that P exhibited the largest individual effect on TS and BFI. It is also seen from this work that the nature of binders in combination affects the influence that P and G had on the TS or BFI.

Native and microwave-modified Terminalia mantaly gums as sustained-release and bioadhesive excipients in naproxen matrix tablet formulations

“…21 Crushing strength provides a measure of tablet strength, while friability is a measure of tablet weakness. 22 In this study, the highest crushing strength was observed with MTM60 (40.41 N, tablet F9), followed by MTM20 (Table 4). Table 4 also clearly shows that crushing strength increased as the gum and HPMC concentrations increased, resulting in the ranking MTM60 > MTM 20 > NTM.…”

A quantitative study of the influence of coprocessing of binders on the mechanical properties of paracetamol tablets

“…This was probably due to the reduction in NMG concentration in the coprocessed binders. The reduction in NMG concentration allowed for more adhesive forces to predominate, hence, pressure would be necessary to effect more particle -particle interaction of the granulation due to creation of more binding surfaces caused by breakage of granules (Alebiowu, Ojeleye, 2007). On the other hand, the ranking obtained for NMG/CP4 and NMG/CP5 combination binders was P > N > C. In these binders, the MCC concentration is much higher than that of NMG.…”

“…To study the effect of the nature of the binding agent (denoted by N), concentration of the binding agent (denoted by C), applied pressure (denoted by P) on tensile strength and brittle fracture of Paracetamol tablets made from each of the binding agents, experiments were performed in a factorial design involving the application of simple statistics (Woolfall, 1964, Alebiowu andOjeleye, 2007). The basis of the experimental design was that each of the three variables was used at a "high" level (denoted by the subscript H) and a "low" level (denoted by the subscript L).…”

Influence of process variables on release properties of paracetamol tablets

“…To study the effect of the nature of starch as a binding agent, its concentration and relative density of the tablet on disintegration and dissolution times of paracetamol tablets, experiments were performed in a factorial design that involved the application of simple statistics (1)(2)(3)(4)(5). In this factorial design, formulations were only mathematically combined.…”

“…A zero result indicates no interaction, but if the interaction coefficient was significantly removed from zero, then the two variables concerned were interacting with each other. The extent of removal from zero is a measure of the magnitude of interaction (1)(2)(3)(4)(5). All measurements were made in triplicate and the results given are the mean values.…”