Influence of Biochemical Alterations on Arterial Stiffness in Patients With End-stage Renal Disease

Blacher, Jacques; Demuth, Karine; Guérin, Alain P.; Safar, Michel E.; Moatti, N.; London, Gérard M.

doi:10.1161/01.atv.18.4.535

Cited by 190 publications

(132 citation statements)

References 52 publications

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“…There is controversy over the effect of disorders of lipid metabolism on aortic compliance. In several cross-sectional studies, lipid profile was not a determinant of PWV, 5,6,9,29 whereas serum triglyceride correlated positively with ba-PWV in hemodialysis patients 30 and increments in ba-PWV. 28 Furthermore, intermediate-density lipoprotein cholesterol, which contains cholesterol and triglyceride, was an independent risk factor for arteriosclerosis.…”

Section: Discussionmentioning

confidence: 89%

“…Increased aortic stiffness, as assessed by pulse wave velocity (PWV), is an independent poor prognostic factor for cardiovascular disease and all-cause mortality in patients with ESRD. 3,4 Several studies showed that age, vascular calcification, 5,6 presence of diabetes mellitus 6 and vertebral bone mineral density 7 are determinants of aortic PWV in ESRD patients treated with hemodialysis (HD). Recently, we described that hemoglobin A1c was an independent contributor to aortic PWV not only in diabetic HD patients, but also in non-diabetic HD patients.…”

Section: Introductionmentioning

confidence: 99%

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What factors accelerate aortic stiffening in hemodialysis patients? An observational study

Matsumae¹,

Abe

Nishimura³

et al. 2010

Hypertens Res

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Increased aortic stiffness is an independent predictor of death from cardiovascular disease in patients with end-stage renal disease (ESRD). Various factors that contribute to carotid-femoral pulse wave velocity (cfPWV) as a surrogate of aortic stiffness have been identified, but determinants of long-term worsening of aortic stiffness remain to be elucidated. To clarify the factors that accelerate aortic stiffness in hemodialysis patients, 148 patients with ESRD on hemodialysis were evaluated. At baseline, cfPWV and ankle-brachial blood pressure index (ABPI) were measured and clinical status including biochemical parameters, with or without hepatitis c virus (HCV) infection, diabetes mellitus (DM), cardiovascular disease, cerebrovascular disease and peripheral arterial disease at baseline, were evaluated. The cfPWV was measured again after a 3-year follow up and the annual change in cfPWV was calculated. The cfPWV decreased in 54 patients, worsened slowly in 47 (annual change in cfPWV ranged from 0 to 0.33 m s À1 per year), and worsened rapidly in 47 patients (annual change in cfPWV was more than 0.33 m s À1 per year). The prevalences of DM, HCV infection and peripheral arterial disease were the highest in the rapid progression group. Univariate analysis showed that age, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C ratio, HCV infection, ABPI and number of vasculopathies were significantly associated with annual change in cfPWV. Stepwise regression analysis identified ABPI, LDL-C/HDL-C ratio and HCV infection as independent determinants of worsening of cfPWV. Further studies are needed to investigate the mechanism of HCV-related enhancement of aortic stiffness in ESRD patients.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

What factors accelerate aortic stiffening in hemodialysis patients? An observational study

Matsumae¹,

Abe

Nishimura³

et al. 2010

Hypertens Res

View full text Add to dashboard Cite

show abstract

“…Several lines of evidence suggest that pulse wave velocity (PWV) in patients with end-stage renal disease (ESRD) is elevated and predicts future cardiovascular disease and death (21)(22)(23). Furthermore, in one screened cohort, increased PWV was associated with low creatinine clearance, age, systolic blood pressure, proteinuria, fasting glucose, and cholesterol (12).…”

Section: Discussionmentioning

confidence: 99%

Serum Cystatin C Is Related to Pulse Wave Velocity Even in Subjects with Normal Serum Creatinine

et al. 2008

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We hypothesized that serum cystatin C can be a more predictable marker of arterial stiffness than serum creatinine and creatinine-based glomerular filtration rate (GFR). The aim of this study is to evaluate whether serum cystatin C is related to arterial stiffness independently of serum creatinine in subjects for whom serum creatinine is normal. A total of 2,018 individuals (1,120 males, 898 females) were enrolled. Mean brachial-ankle pulse wave velocity (baPWV) was used as a marker of arterial stiffness and sex-specific analysis

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“…62 321; Biomérieux, Marcy-l'Etoile, France). Homocysteine level was estimated in plasma as previously described (Blacher et al, 1998).…”

Section: Biochemical Analysesmentioning

confidence: 99%

The regular consumption of a polyphenol-rich apple does not influence endothelial function: a randomised double-blind trial in hypercholesterolemic adults

et al. 2010

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Background/objectives: Epidemiological studies suggest that apple consumption is associated with a reduction in cardiovascular disease risk. Apple polyphenols may contribute to explain these effects. Endothelial dysfunction has been associated with early stage of atherosclerosis and polyphenols from various dietary sources have been shown to reverse it. The aim of the present study was to investigate the effect of the consumption of a polyphenol-rich apple on endothelial function. Subjects/methods: In all, 30 hypercholesterolemic volunteers were included in a double-blind, randomized crossover trial. They successively consumed 40 g of two lyophilized apples, polyphenol-rich and polyphenol-poor, providing respectively 1.43 and 0.21 g polyphenols per day during two 4-week periods separated by a 4-week washout period. Results: Brachial artery flow-mediated vasodilation (FMD) was assessed at the beginning and at the end of each intervention period. FMD did not differ between the polyphenol-rich and the polyphenol-poor apples, neither did the other cardiovascular disease risk factors (plasma lipids, homocysteine, antioxidant capacity). Conclusions: These data suggest that over a 4-week period, the consumption of a polyphenol-rich apple does not improve vascular function in hypercholesterolemic patients.

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Influence of Biochemical Alterations on Arterial Stiffness in Patients With End-stage Renal Disease

Cited by 190 publications

References 52 publications

What factors accelerate aortic stiffening in hemodialysis patients? An observational study

What factors accelerate aortic stiffening in hemodialysis patients? An observational study

Serum Cystatin C Is Related to Pulse Wave Velocity Even in Subjects with Normal Serum Creatinine

The regular consumption of a polyphenol-rich apple does not influence endothelial function: a randomised double-blind trial in hypercholesterolemic adults

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