Influence of birth size and body composition on bone mineral density in early adulthood: the PROGRAM study

Leunissen, Ralph W. J.; Stijnen, Theo; Boot, Annemieke M.; Hokken-Koelega, Anita

doi:10.1111/j.1365-2265.2008.03226.x

Cited by 38 publications

(51 citation statements)

References 44 publications

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“…Similarly, positive associations have been observed between birth weight and bone mineral content (BMC) in young adults, postmenopausal women and elderly [16,17]. However, inverse associations between birth weight and bone mineral density and content have also been reported in pre-pubertal children [11] and young adults [18]. A recent meta-analysis concludes that the association between birth weight on BMD and BMC are positive in children and stronger with BMC as outcome, while there is lack of evidence concerning adolescents [19].…”

Section: Introductionmentioning

confidence: 97%

The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures

et al. 2017

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The influence of birth weight and length on bone mineral density and content in adolescence. The Tromsø Study, Fit Futures.Purpose: The influence of birth weight and length on bone mineral density and content later in life is unclear, especially in adolescence. This study evaluated the impact of birth weight and length on bone mineral density and content among adolescents.Methods: We included 961 participants from the population-based Fit Future study (2010)(2011). Dual-energy X-ray absorptiometry (DXA) was used to measure bone mineral density (BMD) and bone mineral content (BMC) at femoral neck (FN), total hip (TH) and total body (TB). BMD and BMC measures were linked with birth weight and length ascertained from the Medical Birth Registry of Norway. Linear regression models were used to investigate the influence of birth parameters on BMD and BMC. Corresponding analyses using birth length as exposure gave significantly positive associations with BMC at all sites in both sexes. The significant positive association between birth weight 3 and BMC-TB in girls, and birth length and BMC-TB in boys remained after multivariable adjustment.Conclusions: We found a positive association between birth size and BMC in adolescence.However, this association was attenuated after adjustment for weight, height and physical activity during adolescence.

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Section: Introductionmentioning

confidence: 97%

The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures

et al. 2017

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“…BMI is an inaccurate tool for measuring body morphology, and an interesting development has been the analysis of changes in body composition and its effect on BMD. This research was largely limited to young women (15,16), particularly those recovering from anorexia nervosa. These subjects were not a representative of the general population, but preliminary results reveal that BMD increases with increasing body fat mass (FM).…”

Section: Introductionmentioning

confidence: 99%

Increasing body fat mass reverses bone loss in osteopenia as detected by dual-energy X-ray absorptiometry scans

Hedges

Bukhari

2016

Eur J Rheumatol

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Objective: Low body mass index (BMI) is a known risk factor for osteoporosis and is part of the FRAX™ 10-year fracture risk stratification tool for predicting fragility fractures. Little is known regarding the effects of changing body composition on bone mineral density (BMD). However, increasing fat mass (FM) improves BMD in young women with anorexia nervosa. This study aimed to assess whether changes in FM over time affected BMD in the general population.Material and Methods: Data was collected from patients who underwent dual-energy X-ray absorptiometry (DEXA) assessment between 2004 and 2011. Patients were included if they had multiple scans, including FM measurements. Our scanners limited these to scans of the lumbar spine. Linear regression analysis was performed to identify the relationship between changes in FM and BMD. Backwards stepwise linear regression analysis was performed to identify confounding factors, including sex, risk factors, previous fractures, and baseline BMI.Results: In this study, 23,239 patients were included, of which 702 met the inclusion criteria. There were 609 (86%) females and 93 (13%) males with a mean age of 64.5 (SD 11.2) years at first scan. We identified a strong positive correlation between increasing FM and BMD between scans (coefficient 28.4; p<0.01; 95% CI, 26.6-30.1). Previous pelvic and femur fractures and a history of inflammatory diseases were also associated with increasing FM (p<0.05). This relationship was true regardless of patients BMI at their first scan.Conclusion: These findings suggest that patients at high risk of fragility fractures should be encouraged to increase their FM as long as they are at a low risk for disease states related to high FM.

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“…However, in adolescent studies, the association between BMC and BW was unclear and inconsistent [17]. Some have reported positive associations between BW and WB, spine, and FN-BMC [18,19], while others have reported no association between BW and BMC [20,21]. Steer and Tobias have reported an inverse association between BW and total body BMC [22].…”

Section: Discussionmentioning

confidence: 99%

Birth Weight Could Influence Bone Mineral Contents of 10- to 18-Year-Old Korean Adolescents: Results from the Korea National Health and Nutrition Examination Survey (KNHANES) 2010

et al. 2016

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Background: We investigate the relationship between birth weight (BW) and bone mineral content (BMC) in Korean adolescents. Methods: Data were obtained from the Korea National Health and Nutrition Examination Survey conducted in 2010. Baseline characteristics were compared according to age- and sex-specific BMC quartiles of total body less head (TBLH), lumbar spine (LS) and femur neck (FN) in 10- to 18-year-old adolescents (male = 474, female = 394). Results: BW showed a positive correlation with current weight-SDS (p = 0.006 in males, p = 0.008 in females). BW according to TBLH-BMC quartile groups (p for trend <0.003 in males, <0.0001 in females), LS-BMC quartile groups (p for trend <0.034 in males) and FN-BMC quartile groups (p for trend <0.008 in males, <0.020 in females) showed significant differences. The odds ratio (OR) of being in the highest BMC quartile, per 1-kg increase in BW, was significantly increased in TBLH-BMC (OR = 2.14 in males, OR = 3.26 in >16-year-old adolescents) and FN-BMC (OR = 2.62 in males, OR = 3.06 in >16-year-old adolescents) after adjusting for age, height, smoking, drinking, metabolic equivalent of task, and gestational age. Conclusion: BW might be one of the determinant factors of BMC in Korean adolescents.

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Influence of birth size and body composition on bone mineral density in early adulthood: the PROGRAM study

Abstract: Prenatal growth has no significant influence on BMD(TB) and BMD(LS) in early adulthood. Gender and postnatal growth, particularly weight gain, are the main positive determinants. To achieve a normal BMD in adulthood, healthcare workers should aim for a normal weight gain in children.

Cited by 38 publications

References 44 publications

The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures

The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures

Increasing body fat mass reverses bone loss in osteopenia as detected by dual-energy X-ray absorptiometry scans

Birth Weight Could Influence Bone Mineral Contents of 10- to 18-Year-Old Korean Adolescents: Results from the Korea National Health and Nutrition Examination Survey (KNHANES) 2010

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