Influence of bisfenol A on chemical coding of the nerve fibers of the cardiac apex in the domestic pig

Makowska, Krystyna; Szymańska, Kamila; Palus, Katarzyna; Gonkowski, Sławomir; Całka, Jarosław

doi:10.21521/mw.5768

Cited by 5 publications

(11 citation statements)

References 37 publications

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“…The knowledge of the influence of BPA on the peripheral nervous system is more limited than on the central nervous system. It is known that BPA inhibits the voltage-gated sodium channels in dorsal root ganglia and may change the neurochemical characterization in autonomic nervous structures supplying various internal organs [ 60 , 88 , 89 , 90 , 91 ]. The decrease in total number of neurons noted in the present study under the impact of BPA also confirms neurotoxic properties of this substance.…”

Section: Discussionmentioning

confidence: 99%

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

Szymańska

Makowska

Całka

et al. 2020

IJMS

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The enteric nervous system (ENS), located in the wall of the gastrointestinal (GI) tract, is characterized by complex organization and a high degree of neurochemical diversity of neurons. One of the less known active neuronal substances found in the enteric neurons is neuregulin 1 (NRG1), a factor known to be involved in the assurance of normal development of the nervous system. During the study, made up using the double immunofluorescence technique, the presence of NRG1 in the ENS of the selected segment of porcine large intestine (caecum, ascending and descending colon) was observed in physiological conditions, as well as under the impact of low and high doses of bisphenol A (BPA) which is commonly used in the production of plastics. In control animals in all types of the enteric plexuses, the percentage of NRG1-positive neurons oscillated around 20% of all neurons. The administration of BPA caused an increase in the number of NRG1-positive neurons in all types of the enteric plexuses and in all segments of the large intestine studied. The most visible changes were noted in the inner submucous plexus of the ascending colon, where in animals treated with high doses of BPA, the percentage of NRG1-positive neurons amounted to above 45% of all neuronal cells. The mechanisms of observed changes are not entirely clear, but probably result from neurotoxic, neurodegenerative and/or proinflammatory activity of BPA and are protective and adaptive in nature.

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Section: Discussionmentioning

confidence: 99%

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

Szymańska

Makowska

Całka

et al. 2020

IJMS

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“…Previous studies have shown a link between excessive exposure to BPA and various civilization diseases, including diabetes, hypertension, heart attack, or neoplasms [ 31 ]. Moreover, it is known that BPA changes the neurochemical characterization of neurons and nerves within the peripheral nervous system in various internal organ including intestine, heart, and liver [ 32 , 33 , 34 , 35 ], but until now the participation of NRG-1 in mechanisms connected with BPA intoxication has not been studied.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Bisphenol A (BPA) on Neuregulin 1-Like Immunoreactive Nerve Fibers in the Wall of Porcine Uterus

Rytel

2018

IJMS

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Bisphenol A (BPA), a substance commonly used in the manufacture of plastics, shows multidirectional negative effects on humans and animals. Due to similarities to estrogens, BPA initially leads to disorders in the reproductive system. On the other hand, it is known that neuregulin 1 (NRG-1) is an active substance which enhances the survivability of cells, inhibits apoptosis, and protects tissues against damaging factors. Because the influence of BPA on the nervous system has also been described, the aim of the present study was to investigate for the first time the influence of various doses of BPA on neuregulin 1-like immunoreactive (NRG-1-LI) nerves located in the porcine uterus using the routine single- and double-immunofluorescence technique. The obtained results have shown that BPA increases the number and affects the neurochemical characterization of NRG-1-LI in the uterus, and changes are visible even under the impact of small doses of this toxin. The character of observed changes depended on the dose of BPA and the part of the uterus studied. These observations suggest that NRG-1 in nerves supplying the uterus may play roles in adaptive and protective mechanisms under the impact of BPA.

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“…They were fed twice a day with commercial standard feed for piglets and had unlimited access to drinking water. The animals’ care during the experiment was previously described by Makowska et al [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

“…Other studies have shown that BPA intensifies atherosclerosis processes in the cardiovascular system [ 15 , 16 ] and oxidative stress reactions in cardiomyocytes [ 17 ]. In turn, the authors’ previous study showed that BPA in high doses affects the neurochemical characterization of nerves located in the heart wall [ 18 ]. Moreover, it is known that BPA increases the risk of perimyocarditis and fibrosis after viral infections [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…One of them is the influence of BPA on the neurochemical characterization of nerves supplying the heart. Previous studies have indicated that changes in the expression of active substances in the nerves within the heart wall may appear under the impact of higher doses of BPA [ 18 ]. On the other hand, whether changes in the neurochemical characterization of nerves in the heart wall are also caused by lower doses of BPA remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Changes Caused by Low Doses of Bisphenol A (BPA) in the Neuro-Chemistry of Nerves Located in the Porcine Heart

Makowska

Gonkowski

2021

Animals

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Bisphenol A (BPA) contained in plastics used in the production of various everyday objects may leach from these items and contaminate food, water and air. As an endocrine disruptor, BPA negatively affects many internal organs and systems. Exposure to BPA also contributes to heart and cardiovascular system dysfunction, but many aspects connected with this activity remain unknown. Therefore, this study aimed to investigate the impact of BPA in a dose of 0.05 mg/kg body weight/day (in many countries such a dose is regarded as a tolerable daily intake–TDI dose of BPA–completely safe for living organisms) on the neurochemical characterization of nerves located in the heart wall using the immunofluorescence technique. The obtained results indicate that BPA (even in such a relatively low dose) increases the number of nerves immunoreactive to neuropeptide Y, substance P and tyrosine hydroxylase (used here as a marker of sympathetic innervation). However, BPA did not change the number of nerves immunoreactive to vesicular acetylcholine transporter (used here as a marker of cholinergic structures). These observations suggest that changes in the heart innervation may be at the root of BPA-induced circulatory disturbances, as well as arrhythmogenic and/or proinflammatory effects of this endocrine disruptor. Moreover, changes in the neurochemical characterization of nerves in the heart wall may be the first sign of exposure to BPA.

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Influence of bisfenol A on chemical coding of the nerve fibers of the cardiac apex in the domestic pig

Abstract: Influence of bisfenol A on chemical coding of the nerve fibers of the cardiac apex in the domestic pig

Cited by 5 publications

References 37 publications

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

The Influence of Bisphenol A (BPA) on Neuregulin 1-Like Immunoreactive Nerve Fibers in the Wall of Porcine Uterus

Changes Caused by Low Doses of Bisphenol A (BPA) in the Neuro-Chemistry of Nerves Located in the Porcine Heart

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