Influence of blood glucose on the expression of glucose transporter proteins 1 and 3 in the brain of diabetic rats

Hou, Wei-Kai; Yang, Xian; Zhang, Li; Li, Hong; Hou, Xin-Guo; Xu, Yuxin; Yu, Tao; Xu, Fang; Song, Jun; Fu, Chunli; Zhang, Wen; Chen, Li

doi:10.1097/00029330-200710010-00013

Cited by 56 publications

(37 citation statements)

References 19 publications

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“…Specifically, up-regulation of glucose transporters has been correlated to hypoglycemia suggesting an increase in BBB glucose extraction [83,92,93]. By contrast, hyperglycemia appears to down-regulate glucose transporters [63,78], although in vivo studies so far have provided controversial results. Alteration of glucose metabolism has also been suggested as having a role in the pathophysiology of diabetes at the BBB.…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that the biological answer to chronic excess of glucose in the systemic circulation should be down regulation of its transporters. In this line, many experimental studies report a down-regulation of BBB glucose transporters in hyperglycemic animals [63,78,79], indicating the measures taken by brain from preventing excessive glucose intake. However, this is not a universal scientific consensus since other studies (in both animals and humans) did not reveal significant changes in the BBB glucose transporters expression in DM [41,80-83].…”

Section: Effect Of Hyperglycemia On Bbb Glucose Transport In Dmmentioning

confidence: 99%

“…Down-regulation of glucose transporters was independent of the method used to induce DM in vivo [78]. Local cerebral glucose utilization during chronic but not acute hyperglycemia was increased in DM Sprague–Dawley rat models.…”

Section: Effect Of Hyperglycemia On Bbb Glucose Transport In Dmmentioning

confidence: 99%

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Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview

Prasad

Sajja

Naik

et al. 2014

J Pharmacovigilance

151

106

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A host of diabetes-related insults to the central nervous system (CNS) have been clearly documented in type-1 and -2 diabetic patients as well as experimental animal models. These host of neurological disorders encompass hemodynamic impairments (e.g., stroke), vascular dementia, cognitive deficits (mild to moderate), as well as a number of neurochemical, electrophysiological and behavioral alterations. The underlying causes of diabetes-induced CNS complications are multifactorial and are relatively little understood although it is now evident that blood-brain barrier (BBB) damage plays a significant role in diabetes-dependent CNS disorders. Changes in plasma glucose levels (hyper- or hypoglycemia) have been associated with altered BBB transport functions (e.g., glucose, insulin, choline, amino acids, etc.), integrity (tight junction disruption), and oxidative stress in the CNS microcapillaries. Last two implicating a potential causal role for upregulation and activation of the receptor for advanced glycation end products (RAGE). This type I membrane-protein also transports amyloid-beta (Aβ) from the blood into the brain across the BBB thus, establishing a link between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD, also referred to as “type 3 diabetes”). Hyperglycemia has been associated with progression of cerebral ischemia and the consequent enhancement of secondary brain injury. Difficulty in detecting vascular impairments in the large, heterogeneous brain microvascular bed and dissecting out the impact of hyper- and hypoglycemia in vivo has led to controversial results especially with regard to the effects of diabetes on BBB. In this article, we review the major findings and current knowledge with regard to the impact of diabetes on BBB integrity and function as well as specific brain microvascular effects of hyper- and hypoglycemia.

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Section: Discussionmentioning

confidence: 99%

Section: Effect Of Hyperglycemia On Bbb Glucose Transport In Dmmentioning

confidence: 99%

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Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview

Prasad

Sajja

Naik

et al. 2014

J Pharmacovigilance

151

106

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“…Despite being a peripheral disease, diabetes is able to induce alterations in BBB permeability [67], and this may be a mechanism for its role in VD caused by small vessels disease. In a rat model of diabetes it has been shown that the expression of GLUT-1 and GLUT-3 is downregulated, probably by an adaptive mechanism of protection against sustained high blood glucose levels [68]. Furthermore, in an in vitro BBB model and in streptozotocin-induced diabetic rats, the efflux transporter Pglycoprotein was found to be upregulated by high glucose through a NF-κB-dependent mechanism [69].…”

Section: Ageing Impact On Blood-brain Barriermentioning

confidence: 99%

Blood-brain barrier alterations in ageing and dementia

Popescu

Toescu

Popescu

et al. 2009

Journal of the Neurological Sciences

203

125

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“…al. (30) observed downregulation of GLUT3 in streptozotocin-diabetic rat brains, while cerebral ischemia/reperfusion in diabetic rats resulted in dynamic expression of the transporter (31). In AD where disturbed glucose homeostasis and brain hypometabolism are one of the features of this disease, GLUT3 expression was downregulated in human frontal cortex (32).…”

Section: Introductionmentioning

confidence: 99%

Inside the Diabetic Brain

Chomova

2014

Acta Medica Martiniana

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A b s t r a c t CNS complications resulting from diabetes mellitus (DM) are a problem gaining more acceptance and attention in the recent years. Both types 1 and 2 DM represent an significant risk factor for decreased cognitive functions, memory and learning deficits as well as development of Alzheimer's disease. Chronic hyperglycemia through protein glycation and increased oxidative stress contributes to brain dysfunction, however increasing evidences suggest that the pathology of DM in the brain involves a progressive and coordinated disruption of insulin signaling, with profound consequences for brain function and plasticity. Since many of the CNS changes observed in diabetic patients and animal models of DM are reminiscent of the changes seen in aging, the theory of advanced brain aging in DM has been proposed. This review summarizes the findings of the literature regarding the effects of DM on the brain in the terms of diabetes-related metabolic derangements and intracellular signaling.

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Influence of blood glucose on the expression of glucose transporter proteins 1 and 3 in the brain of diabetic rats

Cited by 56 publications

References 19 publications

Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview

Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview

Blood-brain barrier alterations in ageing and dementia

Inside the Diabetic Brain

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