Influence of blood transfusions on tumor recurrence and survival rate in colorectal carcinoma

Liewald, F.; Wirsching, R.; Zülke, C.; Demmel, N.; Mempel, W

doi:10.1016/0277-5379(90)90230-q

Cited by 33 publications

(10 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, cancer stage is similar to the data presented by other authors (4)(5)(6)(7)(8)(9)(10)(18)(19)(20). Comparing clinical advancement according to the Astler-Coller system, we did not observe any significant differences between the two groups T and NT.…”

Section: Discussionsupporting

confidence: 89%

“…The studies from the eighties showed worse prognoses in transfused patients (5,6,9,27). At that time, more patients were transfused, the amount of transfused blood was higher and more often the whole blood was transfused.…”

Section: Discussionmentioning

confidence: 97%

“…Patients who received blood during the peri-operative period present a greater risk of infective complications (2)(3)(4)(5). Some authors thought that blood transfusion was connected to poorer survival in cancer patients while others did not observe such a relationship (6)(7)(8)(9)(10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 96%

See 2 more Smart Citations

The Impact of Homologous Packed Red Blood Cell Transfusion on Patients’ Survival after Radical Surgical Treatment of Colorectal Cancer

Łobaziewicz

Kołodziejski

2008

Acta Chirurgica Belgica

View full text Add to dashboard Cite

The aim of this study was to assess the impact of homologous packed red blood cell transfusion on patients' survival after radical surgical treatment of colorectal cancer. We analyzed a group of 257 colorectal cancer patients who had undergone radical operations (R0 resection) and who had been followed-up for at least 30 months. Overall survival (OS), disease specific survival (DSS), disease free survival (DFS), free of local recurrence survival (FLR) and free of metastases survival (FM) were recorded. 122 (47.5%) patients received packed red blood cells in the peri-operative period (group T), whereas 135 patients did not receive any blood (group NT). Neither group (T and NT) differed in clinical outcome, non-haemorrhagic complications, cause of death during the follow-up period, or results of surgical treatment. The fact of packed red blood cell transfusion was not significantly prognostic of outcome in Cox's multivariate analysis. Also the survival curves of 63 pairs of patients selected from groups T and NT, according to classical prognostic features, had similar courses.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

The Impact of Homologous Packed Red Blood Cell Transfusion on Patients’ Survival after Radical Surgical Treatment of Colorectal Cancer

Łobaziewicz

Kołodziejski

2008

Acta Chirurgica Belgica

View full text Add to dashboard Cite

show abstract

“…[7–9, 25–27] Ojima and colleagues found that PBT independently increased the risk of overall mortality by a factor of 2.7 in patients undergoing curative gastrectomy for gastric cancer, and others have reported a 3% increased mortality risk per transfused unit in patients undergoing liver resection for hepatocellular carcinoma[7, 8]. Another study of patients with hepatocellular carcinoma found a 2-fold increased mortality risk associated with PBT[9].…”

Section: Discussionmentioning

confidence: 99%

The relationship between perioperative blood transfusion and overall mortality in patients undergoing radical cystectomy for bladder cancer

Morgan

Barocas

Chang

et al. 2013

Urologic Oncology: Seminars and Original Investigations

View full text Add to dashboard Cite

Objectives The relationship between perioperative blood transfusion (PBT) and oncologic outcomes is controversial. In patients undergoing surgery for colon cancer and several other solid malignancies, PBT has been associated with an increased risk of mortality. Yet, the urologic literature has a paucity of data addressing this topic. We sought to evaluate whether PBT affects overall survival following radical cystectomy (RC) for patients with bladder cancer. Methods The medical records of 777 consecutive patients undergoing RC for urothelial carcinoma of the bladder were reviewed. PBT was defined as transfusion of red blood cells during RC or within the postoperative hospitalization. The primary outcome was overall survival. Clinical and pathologic variables were compared using chi-squared tests, and Cox multivariate survival analyses were performed. Results A total of 323 patients (41.6%) underwent PBT. In the univariate analysis, PBT was associated with increased overall mortality (HR 1.40, 95%CI 1.11–1.78). Additionally, an independent association was demonstrated in a nontransformed logistic regression model(HR, 95%CI 1.01–1.36) but not in a model utilizing restricted cubic splines(HR 1.03, 95%CI 0.77–1.38). The c-index was 0.78 for the first model and 0.79 for the second. Conclusions In a traditional multivariate model, mirroring those that have been applied to this question in the general surgery literature, we demonstrated an association between PBT and overall mortality after RC. However, this relationship is not observed in a second statistical model. Given the complex nature of adequately controlling for confounding factors in studies of PBT, prospective study will be necessary to fully elucidate the independent risks associated with PBT.

show abstract

“…Many observational studies have described an association between perioperative allogeneic blood transfusion and higher rates of postoperative complications and tumor recurrence. [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] However, it remains controversial whether a perioperative blood transfusion alters the incidence of disease recurrence or otherwise affects the prognosis. Recently, Amato and Pescatori systemically reviewed 36 studies on 12 127 patients and concluded that although a perioperative blood transfusion has detrimental effects on the recurrence of curable colorectal cancers, a causal relationship still cannot be claimed due to the detection of heterogeneity, and no defi nitive conclusions on the effects of surgical techniques could be drawn.…”

Section: Host-tumor Interactions During Surgery (State Of Intraoperatmentioning

confidence: 99%

Perioperative host-tumor inflammatory interactions: A potential trigger for disease recurrence following a curative resection for colorectal cancer

et al. 2008

View full text Add to dashboard Cite

The aim of the present review was to investigate whether host-tumor interactions are causal or consecutive clinical factors associated with surgical stress that influence the long-term survival after a curative resection of colorectal cancer. A Medline/PubMed search was conducted to identify the relevant articles investigating the factors related to surgical stress and their effects on the long-term survival after a curative resection of colorectal cancer. The intraoperative state is defined as a cytokine storm in which ongoing local cytokine production occurs at the site of the tumor, thus further enhancing the autocrine cytokine loop for angiogenic factor production. The postoperative state is defined as tissue regeneration in which surgery-related clinical events enhance the systemic induction of inflammatory cytokines, which in turn synergistically exaggerate the local activation of tumor growth factors. Host-tumor interactions under surgical stress may act synergistically as potent tumor growth factors, and may thus influence long-term survival. Controlling surgical insults and/or regulating perioperative inflammatory responses may therefore lead to new therapeutic approaches for controlling disease recurrence.

show abstract

Influence of blood transfusions on tumor recurrence and survival rate in colorectal carcinoma

Cited by 33 publications

References 14 publications

The Impact of Homologous Packed Red Blood Cell Transfusion on Patients’ Survival after Radical Surgical Treatment of Colorectal Cancer

The Impact of Homologous Packed Red Blood Cell Transfusion on Patients’ Survival after Radical Surgical Treatment of Colorectal Cancer

The relationship between perioperative blood transfusion and overall mortality in patients undergoing radical cystectomy for bladder cancer

Perioperative host-tumor inflammatory interactions: A potential trigger for disease recurrence following a curative resection for colorectal cancer

Contact Info

Product

Resources

About