Influence of body mass index in anti-Müllerian hormone levels in 951 non-polycystic ovarian syndrome women followed at a reproductive medicine unit

Simões‐Pereira, Joana; Nunes, Joaquim; Aguiar, Ana Júlia Felipe Camelo; Sousa, Sandra; Rodrigues, Cátia; Matias, Joaquim Sampaio; Calhaz‐Jorge, Carlos

doi:10.1007/s12020-018-1555-y

Cited by 37 publications

(18 citation statements)

References 19 publications

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“…In one respect the data presented here differ from those of other reports in the relationship between AMH and obesity. Most investigators report a negative association between AMH and BMI (16,17), and others find no association (18) or a weak positive association (19). In the current study AMH increased modestly but significantly across the diet group parallel to BMI.…”

Section: Discussioncontrasting

confidence: 40%

Changes in diet composition with urbanization and its effect on the polycystic ovarian syndrome phenotype in a Western Indian population

Kulkarni¹,

Patil²,

Gudi

et al. 2019

Fertility and Sterility

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Objective: To study the effects of increasingly prosperous diet content on clinical features of polycystic ovary syndrome (PCOS). Design: A cross-sectional cohort study of 711 women with PCOS from a heterogeneous population spanning a wide spectrum of socioeconomic strata. Setting: Independent hospital. Patient(s): A total of 711 women with PCOS in whom the diagnosis was based on Rotterdam criteria. Results were compared with a locally recruited reference group. Intervention(s): Clinical assessment of women with PCOS. Main Outcome Measure(s): Clinical characteristics were assessed with particular reference to diet composition. Four diet groups were identified: simple rice with vegetables, vegetarian with mixed carbohydrates, nonvegetarian with mixed carbohydrates, and an urban diet of processed foods. Result(s): Women with PCOS showed the characteristic features of raised LH and androstenedione concentrations and increased ovarian volume and antral follicle count. There was a notable association between an increasingly affluent diet, the presence of hirsutism, raised body mass index, insulin resistance, and higher serum antim€ ullerian hormone concentrations. The positive association between anti-m€ ullerian hormone and body mass index is an unusual feature possibly explained by the wide spectrum of lifestyles in this cohort. Conclusion(s): Urbanization of women in India is associated with increasingly severe phenotype of PCOS, which is likely to have implications on fertility outcomes. (Fertil Steril Ò 2019;112:758-63. Ó2019 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

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Section: Discussioncontrasting

confidence: 40%

Changes in diet composition with urbanization and its effect on the polycystic ovarian syndrome phenotype in a Western Indian population

Kulkarni¹,

Patil²,

Gudi

et al. 2019

Fertility and Sterility

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“… 27 , 28 We detected a negative correlation between AMH and BMI. The results of other studies are controversial; however, 29 - 31 despite the ambiguous relationship between obesity and AMH, the effect of obesity on AMH levels is suggested to be due to the inflammatory and oxidative stress that develops in the ovarian follicular microenvironment. 32 , 33 …”

Section: Discussionmentioning

confidence: 96%

Can we use serum Anti-Mullerian hormone to differentiate the diagnosis between polycystic ovary syndrome patients and healthy women with polycystic ovarian morphology and regular menstrual cycles

Aydoğmuş

Kelekçi

Elmalı

et al. 2018

SMJ

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Objectives:To compare Anti-Mullerian hormone (AMH) concentrations between polycystic ovary syndrome (PCOS) patients and healthy women who have polycystic ovarian morphology (PCOM) with regular menstrual cycles, and to determine a diagnostic cutoff value for PCOS women during reproductive period.Methods:This study was carried out between February 2013 and October 2017 at the Department of Obstetrics and Gynecology, İzmir Katip Çelebi University Atatürk Training and Research Hospital, Izmir, Turkey. Seventy PCOS patients and 70 PCOM women with normal menstrual cycles were included in the study. Blood samples of the subjects were obtained following an 8-hour fast for AMH and biochemical assessments, serum gonadotropin, and androgen measurements.Results:The mean serum AMH levels of PCOS patients were found to be higher than PCOM women with normal menstrual cycles (p<0.01). The optimal serum AMH cutoff value for PCOS diagnosis was determined as 3.51 ng/ml (sensitivity 72.8%, specificity 75.7%).Conclusion:Serum AMH concentrations are significantly higher in PCOS patients independent from the ovarian morphology and number of follicles per ovary. Positive and negative predictive values of AMH in PCOS diagnosis were found to be 75% and 73.6%, respectively, with a cutoff value of 3.51 ng/mL.

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“…Possible reasons for AMH not having been used as a diagnostic marker before nowinclude the different methods of detection, the influence of age, and the body mass index (BMI). [10][11][12] In this clinical analysis, the variation in AMH in each subgroup may also be one of the reasons why it cannot be used as a diagnostic marker of PCOS, since AMH was significantly affected by different characteristics of PCOS. Without PCOM, the mean value of AMH was the same for PCOS patients and healthy controls; however, there are no clear cut-off values for AMH concentrations as for total and free testosterone, especially in adolescents.…”

Section: Amh Levels and Pcosmentioning

confidence: 99%

The Relationship of Anti-Mullerian Hormone in Polycystic Ovary Syndrome Patients with Different Subgroups

Ran¹,

Yi²,

Liu³

2021

DMSO

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Purpose To explore the value of anti-Mullerian hormone (AMH) in patients with polycystic ovary syndrome (PCOS) with different phenotypes and ages, and to identify the relationship between hyperandrogenism (HA) and polycystic ovary morphology (PCOM), in a Chinese cohort. Methods A total of 2262 women (1631 with PCOS and 631 controls) were enrolled. The serum AMH and total testosterone (TT) were analyzed, the AMH levels of each subgroup were compared, and the value of each phenotype and age group of patients with PCOS was evaluated. Results The level of AMH in women with PCOS (mean±SD, 8.63±4.73 ng/mL) was higher than that in controls (5.57±3.31 ng/mL) ( P <0.01). The level of AMH in the PCOM subgroup (11.19±6.4 ng/mL) was significantly higher than that in the HA subgroup (8.58±4.74 ng/mL) ( P <0.01), and both were higher than that in controls ( P <0.01). AMH was higher in PCOS patients than in controls, but the same values were found in subgroups of PCOS patients under 30 years old. Conclusion AMH changed in different subgroups of PCOS, which was the possible reason why AMH was not a diagnostic indicator. However, AMH could help to differentiate between clinical subgroups, as it was strongly related with PCOM but not with HA. AMH changed substantially with age, but was stable in PCOS patients under 30 years old.

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Influence of body mass index in anti-Müllerian hormone levels in 951 non-polycystic ovarian syndrome women followed at a reproductive medicine unit

Cited by 37 publications

References 19 publications

Changes in diet composition with urbanization and its effect on the polycystic ovarian syndrome phenotype in a Western Indian population

Changes in diet composition with urbanization and its effect on the polycystic ovarian syndrome phenotype in a Western Indian population

Can we use serum Anti-Mullerian hormone to differentiate the diagnosis between polycystic ovary syndrome patients and healthy women with polycystic ovarian morphology and regular menstrual cycles

The Relationship of Anti-Mullerian Hormone in Polycystic Ovary Syndrome Patients with Different Subgroups

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