2019
DOI: 10.1007/s00228-019-02662-9
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Influence of body weight and UGT2B7 polymorphism on varenicline exposure in a cohort of smokers from the general population

Abstract: The abstinence rate to tobacco after varenicline treatment is moderate and might be partially affected by variability in varenicline concentrations. This study aimed at characterizing the sources of variability in varenicline pharmacokinetics and to relate varenicline exposure to abstinence. Methods: The population pharmacokinetic analysis (NONMEM®) included 121 varenicline concentrations from 82 individuals and tested the influence of genetic and non-genetic characteristics on apparent clearance (CL/F) and vo… Show more

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