“…It was recently proposed that magnesium phosphate-based cements (MPCs) could be used as an alternative to CPCs. In addition to the increased mechanical strength, which is still not sufficient for load-bearing applications, MPCs have shown a more rapid dissolution rate in aqueous media, which results in enhanced in vivo resorption that favors bone growth; moreover, MPCs have shown intrinsic adhesive capabilities, which are not reported for CPCs. ,, Another advantage of using MPCs over CPCs is that the in vivo release of Mg 2+ was shown to stimulate osteoblast differentiation and to inhibit osteoclast formation, thereby favoring bone regeneration. , Some MPCs were even reported to be naturally antibiotic, , while retaining good biocompatibility both in vitro and in vivo. ,− All these features disclose the great potentialities of MPCs, which are still underexplored in comparison to the well-established CPCs . The properties of MPCs, which are typically prepared by mixing MgO or Mg 3 (PO 4 ) 2 (trimagnesium phosphate, TMP) with aqueous solutions of phosphate salts, can be improved by the addition of modifiers, such as reaction retardants, pore formers, and radio-opaque agents; to the best of our knowledge, the inclusion of bioactive molecules in the cement matrix, as well as their release profile when in contact with biological fluids, has never been addressed so far.…”