Influence of breastfeeding and postnatal nutrition on cardiovascular remodeling induced by fetal growth restriction

Rodríguez-López, Mérida; Osorio, Lyda; Acosta-Rojas, Ruthy; Figueras, Josep; Cruz‐Lemini, M.; Figueras, F.; Bijnens, Bart; Gratacós, E.; Crispi, F.

doi:10.1038/pr.2015.182

Cited by 56 publications

(54 citation statements)

References 40 publications

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“…In addition, children born with IUGR showed additional dietary risk of excess carbohydrate intake, besides cardiovascular remodelling that they undergo during fetal life as an adaptive mechanism to the compromised in utero environment. Unadjusted analysis on a similar cohort as ours, revealed similar dietary pattern of IUGR compared to AGA, suggesting dietary pattern do not vary with the in utero growth status of the children.…”

Section: Discussionsupporting

confidence: 73%

“…Nutrition during childhood plays an important role in influencing cardiovascular health. 7,8 According to growth acceleration hypothesis, increased post-natal growth by a nutrient-enriched diet has an adverse long-term effect on cardiovascular health, particularly among those born with IUGR. [9][10][11][12] According to the International Dietary Guidelines, a healthy diet for young pre-school and school children should have higher energy intake (EI) from carbohydrates (50-55%), a lower EI from fat (30%) and a still lower EI from protein (10-15%).…”

Section: What This Paper Addsmentioning

confidence: 99%

“…Each year, CVD accounts for 47 and 32.2% of all deaths in Europe and Spain, respectively, with its associated economic and social consequences. Nutrition during childhood plays an important role in influencing cardiovascular health . According to growth acceleration hypothesis, increased post‐natal growth by a nutrient‐enriched diet has an adverse long‐term effect on cardiovascular health, particularly among those born with IUGR …”

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confidence: 99%

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Macronutrient and fibre intake of young Spanish children with reference to their in utero growth status: Are they eating a healthy diet?

Nuruddin

Urpí-Sardà

Rodríguez-López

et al. 2018

J Paediatrics Child Health

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Section: Discussionsupporting

confidence: 73%

Section: What This Paper Addsmentioning

confidence: 99%

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confidence: 99%

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Macronutrient and fibre intake of young Spanish children with reference to their in utero growth status: Are they eating a healthy diet?

Nuruddin

Urpí-Sardà

Rodríguez-López

et al. 2018

J Paediatrics Child Health

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“…In humans, FGR induced cardiovascular remodeling at age 5 is ameliorated by breastfeeding but worsened by a high maternal BMI (70). Longitudinal growth analysis suggests that children with higher BP tended to be smaller during third trimester of fetal life but were normal size as infants.…”

Section: Resultsmentioning

confidence: 99%

Pregnancy: An Underutilized Window of Opportunity to Improve Long-term Maternal and Infant Health—An Appeal for Continuous Family Care and Interdisciplinary Communication

2017

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Physiologic adaptations during pregnancy unmask a woman’s predisposition to diseases. Complications are increasingly predicted by first-trimester algorithms, amplify a pre-existing maternal phenotype and accelerate risks for chronic diseases in the offspring up to adulthood (Barker hypothesis). Recent evidence suggests that vice versa, pregnancy diseases also indicate maternal and even grandparent’s risks for chronic diseases (reverse Barker hypothesis). Pub-Med and Embase were reviewed for Mesh terms “fetal programming” and “pregnancy complications combined with maternal disease” until January 2017. Studies linking pregnancy complications to future cardiovascular, metabolic, and thrombotic risks for mother and offspring were reviewed. Women with a history of miscarriage, fetal growth restriction, preeclampsia, preterm delivery, obesity, excessive gestational weight gain, gestational diabetes, subfertility, and thrombophilia more frequently demonstrate with echocardiographic abnormalities, higher fasting insulin, deviating lipids or clotting factors and show defective endothelial function. Thrombophilia hints to thrombotic risks in later life. Pregnancy abnormalities correlate with future cardiovascular and metabolic complications and earlier mortality. Conversely, women with a normal pregnancy have lower rates of subsequent diseases than the general female population creating the term: “Pregnancy as a window for future health.” Although the placenta works as a gatekeeper, many pregnancy complications may lead to sickness and earlier death in later life when the child becomes an adult. The epigenetic mechanisms and the mismatch between pre- and postnatal life have created the term “fetal origin of adult disease.” Up to now, the impact of cardiovascular, metabolic, or thrombotic risk profiles has been investigated separately for mother and child. In this manuscript, we strive to illustrate the consequences for both, fetus and mother within a cohesive perspective and thus try to demonstrate the complex interrelationship of genetics and epigenetics for long-term health of societies and future generations. Maternal–fetal medicine specialists should have a key role in the prevention of non-communicable diseases by implementing a framework for patient consultation and interdisciplinary networks. Health-care providers and policy makers should increasingly invest in a stratified primary prevention and follow-up to reduce the increasing number of manifest cardiovascular and metabolic diseases and to prevent waste of health-care resources.

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“…An adverse prenatal environment during the crucial period of in utero development might have a direct impact on fetal cardiac structure and long-lasting consequences on health [10]. The use of echocardiography during fetal life enables the early identification of subtle or minor changes in cardiac morphometry potentially useful for fetal monitoring and the prevention of cardiovascular consequences [11].…”

Section: Introductionmentioning

confidence: 99%

Nomograms of Fetal Cardiac Dimensions at 18–41 Weeks of Gestation

et al. 2019

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Objective: There is a need for standardized reference values for cardiac dimensions in prenatal life. The objective of the present study was to construct nomograms for fetal cardiac dimensions using a well-defined echocardiographic methodology in a low-risk population. Methods: This is a prospective cohort study including 602 low-risk singleton pregnancies undergoing a standardized fetal echocardiography to accurately assess fetal cardiac, ventricular, and atrial dimensions. Parametric regressions were tested to model each measurement against gestational age from 18 to 41 weeks of gestation. Results: Nomograms were constructed for fetal cardiac dimensions (transverse and longitudinal diameters and areas) of the whole heart, atria, and ventricles, as well as myocardial wall thicknesses. All dimensions showed a progressive increase with gestational age. The best model for most parameters was a second-degree linear polynomial.Fetal cardiac, ventricular, and atrial diameters and areas were successfully obtained in 98.6% of the fetuses, while myocardial wall thicknesses could be obtained in 96.5% of the population. The results showed excellent interobserver and intraobserver reproducibility (intraclass correlation coefficient, ICC > 0.811 and ICC > 0.957, respectively). Conclusions: We provide standardized and comprehensively evaluated reference values for fetal cardiac morphometric parameters across gestation in a low-risk population. These nomograms would enable the early identification of different patterns of fetal cardiac remodeling.

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Influence of breastfeeding and postnatal nutrition on cardiovascular remodeling induced by fetal growth restriction

Cited by 56 publications

References 40 publications

Macronutrient and fibre intake of young Spanish children with reference to their in utero growth status: Are they eating a healthy diet?

Macronutrient and fibre intake of young Spanish children with reference to their in utero growth status: Are they eating a healthy diet?

Pregnancy: An Underutilized Window of Opportunity to Improve Long-term Maternal and Infant Health—An Appeal for Continuous Family Care and Interdisciplinary Communication

Nomograms of Fetal Cardiac Dimensions at 18–41 Weeks of Gestation

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