High density packaging increasingly dominates the market share in LCD highlighting the need not only to decrease the pitch of bonding joints, but also to increase the I/O numbers of driver IC for high-end display applications. However, the shortage between two adjacent electrodes is a major problem when using conventional packaging technologies. Non-Conductive Film (NCF) is one of the interconnection materials which are increasingly used in LCD package and flip chip technology.There are many advantages using NCF in package, such as low cost, simplified process, and low temperature process. On the contrary, NCF bonded faces a challenge of yield. In this paper, we have developed a multi-points compliant bump (MPCB) using in NCF-bonded Chip-on-Flex (COF) process. Evaluating the effect of temperature, time, and load on electric resistance and peeling strength. A higher peeling strength is obtained at higher bonding load, temperature, and time. This indicated that the NCF with high curing degree is sufficient to hold the interconnection joints. The changes in daisy chain after 85 o C/85%RH Thermal Humidity Storage Test (THST) for 500 hrs are measured. Due to MPCB deforms in bonding process, and releases counterforce in reliability test. Experimental results show that low bonding load, high bonding temperature and high bonding time is good for reliability.