Influence of cadmium and copper on tissue element levels of pregnant rats

Abstract

<jats:title>Abstract</jats:title><jats:p>In the current study, we examined the effects of Cd on Cd, Cu, Zn and Fe levels in placenta and maternal and fetal plasma and tissues, the placental weight, total fetal and maternal body weights, and fetal and maternal tissue weights during pregnancy. A total of 21 adult female rats were treated during gestation with drinking water containing one of the following: 70 mg/L of CdCl2, a combination of 70 mg/L of CdCl2 and 70 mg/L of CuSO4, or no addition (control). Placenta Cu and Fe levels, fetal liver and kidney Cu levels, and fetal liver tissue weights were lower in the group administered Cd than in the control group. Also, Cd levels in the placenta, maternal and fetal liver, and maternal kidney were higher in the group treated with Cd than in controls. In the group administered both Cd and Cu, fetal body and tissue weights did not change, but Cd levels in the placenta, maternal and fetal liver, and maternal kidneys were higher than in controls. Zn and Fe levels in the maternal kidney and fetal liver were also lower in this group. Cd exposure during pregnancy resulted in Cd accumulation in maternal and fetal tissues during pregnancy and a decrease in the total weight of fetuses, and the combination of Cd and Cu caused some changes in the both maternal and fetal levels of Cu, Zn, and Fe, but it did not cause changes in the total fetal body weight or the weights of individual tissues.</jats:p>

Effects of sub-chronic Cd exposure on levels of copper, selenium, zinc, iron and other essential metals in rat renal cortex

“…The results of the present studies show that after subchronic administration of a modest dose (0.6 mg/kg SC, 5 days per week for 6–12 weeks), Cd causes significant changes in the renal cortical levels of several key metals, particularly Cu, Se, Fe and Zn. It should be noted that even though many previous studies have shown that Cd can alter renal levels of these metals [11] , [26] , [55] , [53] , there are several aspects of the present studies that are unique and merit special attention.…”

“…However, there is almost no information in the literature regarding the effects of this specific Cd treatment regimen on levels of other metals in the kidney. Most of the previous studies to address this issue involved vastly different treatment regimens in which relatively high doses of Cd were given either orally or intra-peritoneally for relatively short periods of time, typically less than 5 weeks [9] , [10] , [53] , [55] , [61] . Since this model has been so widely used in the Cd field, information regarding the effects of this particular Cd treatment on the levels of metals in the kidney may be especially relevant to previous mechanistic and biomarker studies.…”

“…In addition, most of the metals examined in the present study tend to concentrate in the proximal tubules [45] . However, most of the previous studies on the effects of Cd on metals in the kidney involved the analyses of whole kidneys or kidney homogenates [53] , [55] , [61] an approach that could obscure possible Cd-induced changes in the metal content of the renal cortex. The results of the present studies specifically highlight the Cd-induced changes in the metal content of the renal cortex.…”

Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

“…In addition, some studies have shown favourable effects of pretreatment with other essential elements on Cd toxicity (79,80). Supplementation with minerals has not yet been approved for clinical use, since it is still not clear whether it is effective in subjects with adequate essential element intake, or only in Zn-and/ or Ca-deficient individuals Similarly, the role of supplementation with antioxidants, such as vitamins A, C, or E, has been investigated in experimental settings in order to fi nd an effective way to counter Cd-induced oxidative stress in tissue (14).…”

Male and Female Players may Pomegranate Blood Lipoproteins Effects of Iron and Iron Binding Capacity

“…Vitaminler içersinde C vitamininin sporcuların performansını en üst düzeye çıkarmasında etkileri olduğu bilinmektedir. C vitamini bakımından zengin sebze ve meyvelerin sporcu diyetinde önemli bir yer tutması önem arzetmektedir (12,20,30,38,39,41…”