Influence of cadmium on murine thymocytes: Potentiation of apoptosis and oxidative stress

Pathak, Neelima; Khandelwal, Shashi

doi:10.1016/j.toxlet.2006.02.004

Cited by 76 publications

(54 citation statements)

References 47 publications

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“…. Activities of SOD, GPx, CAT and GST are proven indicators of oxidative stress [ 34,35 ]. Also, these antioxidant enzymes are potential targets for heavy metal toxicity [ 36,37 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Status, Lipid Peroxidation and Testis-histoarchitecture Induced by Lead Nitrate and Mercury Chloride in Male Rats

Baş

Kalender

2016

Braz. arch. biol. technol.

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“…. Activities of SOD, GPx, CAT and GST are proven indicators of oxidative stress [ 34,35 ]. Also, these antioxidant enzymes are potential targets for heavy metal toxicity [ 36,37 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Status, Lipid Peroxidation and Testis-histoarchitecture Induced by Lead Nitrate and Mercury Chloride in Male Rats

Baş

Kalender

2016

Braz. arch. biol. technol.

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“…O 2 ) and hydrogen peroxide (Lopez et al, 2006). Tissue increased levels of malondialdehyde (MDA) and the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) are the proven indicators of oxidative stress Khandelwal, 2006b, Pathak andKhandelwal, 2006a). However, the induced production of ROS is indirect, as Cd is not a redox-active metal and cannot itself direct the Fenton type of reactions.…”

Section: J U S T a C C E P T E Dmentioning

confidence: 99%

Cadmium induces oxidative stress and apoptosis in lung epithelial cells

Kumar

Patil

et al. 2016

Toxicology Mechanisms and Methods

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Abstract:Cadmium (Cd) is one of the well-known highly toxic environmental and industrial pollutants.Cd first accumulates in the nucleus, and later interacts with zinc finger proteins of antiapoptotic genes; inhibit the binding of transcriptional factors and transcription. However, the role of Cd in oxidative stress and apoptosis is less understood. Hence the present study was undertaken to unveil the mechanism of action. A549 cells were treated with or without Cd

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“…The cells were harvested and suspended in PBS. The mitochondrial membrane potential was measured by the fluorescence intensity (FL-1, 530 nm) of 10,000 cells on flow cytometer [20,21].…”

Section: Determination Of the Mitochondrial Membrane Potential By Rhomentioning

confidence: 99%

siRNA targeting midkine inhibits gastric cancer cells growth and induces apoptosis involved caspase-3,8,9 activation and mitochondrial depolarization

Wang

Huang

et al. 2007

J Biomed Sci

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Midkine (MK), a heparin-binding growth factor, is expressed highly in various malignant tumors, so it acts as attractive therapeutic target. In the present study, we used siRNA targeting MK to downregulate human MK expression in human gastric cancer cell line BGC823 and SGC7901 so as to determine the advantages of this anticancer therapeutic. The cell proliferation was evaluated by a WST-8 (4-[3-(2-methoxy-4-nitrophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1, 3-benzene disulfonate sodium salt) assay and colony formation assay. Apoptosis was determined by flow cytometer analysis and colorimetric assay. Our results showed that the BGC823 and SGC7901 cell growth were significantly inhibited by knockdown of MK gene. The loss of mitochondrial membrane potential, release of cytochrome c from the mitochondria into cytosol and increased activity of caspase-3, 8 and 9 occurred concomitantly with inhibition of MK gene. These results indicated that siRNA targeting MK gene can inhibit gastric cancer cells growth and induce apoptosis via mitochondrial depolarization and caspase-3 activation. MK siRNA may be a promising novel and potential therapeutic strategy for the treatment of gastric cancers.

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Influence of cadmium on murine thymocytes: Potentiation of apoptosis and oxidative stress

Cited by 76 publications

References 47 publications

Antioxidant Status, Lipid Peroxidation and Testis-histoarchitecture Induced by Lead Nitrate and Mercury Chloride in Male Rats

Antioxidant Status, Lipid Peroxidation and Testis-histoarchitecture Induced by Lead Nitrate and Mercury Chloride in Male Rats

Cadmium induces oxidative stress and apoptosis in lung epithelial cells

siRNA targeting midkine inhibits gastric cancer cells growth and induces apoptosis involved caspase-3,8,9 activation and mitochondrial depolarization

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