Influence of calcitriol on prolactin and prostaglandin production by human decidua

Delvin, Edgard; Gagnon, Laurence; Arabian, Alice; Gibb, William

doi:10.1016/0303-7207(90)90023-2

Cited by 21 publications

(11 citation statements)

References 25 publications

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“…Calcitriol effects upon other placental hormones such as placental lactogen and prolactin have previously been shown [6,10]. These observations support the concept that calcitriol is a regulator of placental endocrine function.…”

Section: Discussionsupporting

confidence: 68%

“…Furthermore, since calcitriol is an immunosuppressive agent [9] and regulates the synthesis of several cytokines including decidual prolactin [10], it may contribute to the establishment of the fetoplacental unit. The hormones estradiol (E 2 ) and progesterone (P 4 ) are produced from testosterone and pregnenolone by P450-aromatase (CYP19) and 3␤-hydroxysteroid dehydrogenase (3␤-HSD), respectively [11].…”

Section: Introductionmentioning

confidence: 99%

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Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol

Barrera

Avila

Hernández

et al. 2007

The Journal of Steroid Biochemistry and Molecular Biology

172

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol

Barrera

Avila

Hernández

et al. 2007

The Journal of Steroid Biochemistry and Molecular Biology

172

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“…Hydroxylation of vitamin D produces 1α,25‐dihydroxyvitamin D3 [1,25(OH)2D3, calcitriol], which plays key roles in the regulation of calcium homeostasis and bone mineralization . The effects of vitamin D are mediated upon binding to vitamin D receptor (VDR), which is expressed in multiple tissues, including the decidua and placenta . Interaction between vitamin D and its receptor not only inhibits the secretion of pro‐inflammatory cytokines and enhances the antibacterial activity of immune cells, but also promotes trophoblast invasion …”

Section: Introductionmentioning

confidence: 99%

Vitamin D facilitates trophoblast invasion through induction of epithelial‐mesenchymal transition

Kim

Ryu

Lee

et al. 2017

American J Rep Immunol

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“…However, since then, the precise function of this extrarenal CYP27B1 has remained unclear. Coexpression of the receptor for 1,25(OH) 2 D 3 (vitamin D receptor [VDR]) in both decidua (9) and trophoblast (10) suggests that 1,25 (OH) 2 D 3 produced by the placenta may function in an autocrine or paracrine fashion. In support of this, recent studies by our group and others have shown that autocrine metabolism of 25OHD 3 to 1,25(OH) 2 D 3 promotes antibacterial and anti-inflammatory responses in maternal decidua (11) and fetal trophoblast (12,13).…”

mentioning

confidence: 99%

Vitamin D and the Regulation of Placental Inflammation

Liu

Kaplan

Lagishetty

et al. 2011

The Journal of Immunology

183

118

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The vitamin D-activating enzyme 1α-hydroxylase (CYP27B1) and vitamin D receptor (VDR) support anti-inflammatory responses to vitamin D in many tissues. Given the high basal expression of CYP27B1 and VDR in trophoblastic cells from the placenta, we hypothesized that anti-inflammatory effects of vitamin D may be particularly important in this organ. Pregnant wild type (WT) mice i.p. injected with LPS showed elevated expression of mouse Cyp27b1 (4-fold) and VDR (6-fold). Similar results were also obtained after ex vivo treatment of WT placentas with LPS. To assess the functional impact of this, we carried out ex vivo studies using placentas −/− for fetal (trophoblastic) Cyp27b1 or VDR. Vehicle-treated −/− placentas showed increased expression of IFN-γ and decreased expression of IL-10 relative to +/+ placentas. LPS-treated −/− placentas showed increased expression of TLR2, IFN-γ, and IL-6. Array analyses identified other inflammatory factors that are dysregulated in Cyp27b1−/− versus Cyp27b1+/+ placentas after LPS challenge. Data highlighted enhanced expression of IL-4, IL-15, and IL-18, as well as several chemokines and their receptors, in Cyp27b1−/− placentas. Similar results for IL-6 expression were observed with placentas −/− for trophoblastic VDR. Finally, ex vivo treatment of WT placentas with the substrate for Cyp27b1, 25-hydroxyvitamin D3, suppressed LPS-induced expression of IL-6 and the chemokine Ccl11. These data indicate that fetal (trophoblastic) vitamin D plays a pivotal role in controlling placental inflammation. In humans, this may be a key factor in placental responses to infection and associated adverse outcomes of pregnancy.

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Influence of calcitriol on prolactin and prostaglandin production by human decidua

Cited by 21 publications

References 25 publications

Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol

Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol

Vitamin D facilitates trophoblast invasion through induction of epithelial‐mesenchymal transition

Vitamin D and the Regulation of Placental Inflammation

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