Influence of Calcium and Zinc on Lead-induced Alterations in ATPases in the Developing Mouse Brain

Prasanthi, R.P. Jaya; Reddy, Gadi H.; Chetty, C. S.; Reddy, G. Rajarami

doi:10.3923/jpt.2006.270.277

Cited by 3 publications

(1 citation statement)

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“…Ca 2+ ATPase functions in the transfer of Ca 2+ ions across cell membranes, mediating diverse physiological processes such as gene expression, contraction, secretion, fertilization, proliferation and apoptosis (Jiang and Zijiang, 2008;Mata and Sepulveda, 2010). One of the mechanisms through which Pb 2+ exerts its toxic effects is by mimicking the action of Ca 2+ in many physiological processes hence the supplementation of Ca 2+ and Zn 2+ has been shown to ameliorate Pb 2+ toxicity (Prasanthi et al, 2006). This is because these divalent cations compete for the same binding sites as Pb 2+ in the intestinal mucosa.…”

Section: Discussionmentioning

confidence: 99%

Hepatotoxic and neurotoxic effects of combined lead and di-(2-ethylhexyl) phthalate exposure: Activation of total -, Ca2+- and Na+K+- ATPases in the liver of male rats

Abam¹,

Kuyooro²,

Abubakar³

et al. 2021

J. Toxicol. Environ. Health Sci.

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Lead and di-(2-ethylhexyl) phthalate (DEHP) are common environmental toxicants of concern around the world. Although effects of individual exposures to both agents are well documented, there is a dearth of information on the effects of co-exposure to both agents. In this study, combined exposure to lead and DEHP was investigated for effects on ATPase activities in the liver, brain and kidney tissues of rats. Male albino rats were daily exposed to either 200 ppm lead as lead acetate in their drinking water and/or 100 mg DEHP kg -1 body weight in olive oil by gastric intubation for 30 days. Changes in total body weight, relative organ weights as well as brain, hepatic and renal activities of total, Na + K + -, Ca 2+and Mg 2+ -ATPases were used as biomarkers of toxicity. Hepatomegaly and brain atrophy heralded exposure to both agents. Individual exposure to lead and DEHP resulted in reduction in hepatic Ca 2+and Mg 2+ -ATPase activities but no significant effect on total ATPase activity, however combined exposure produced significant activation of Ca 2+ -, Na + K + -and total ATPase while restoring Mg 2+ -ATPase towards control. A potentiating effect on lead by DEHP was observed in hepatic Na + K + -ATPase. Lead stimulated the activities of renal Ca 2+ -and total ATPases while DEHP on the contrary caused significant reduction in total ATPase activity and no significant effects on Ca 2+ -ATPase activity. Co-treatment produced antagonistic effects leading to normal renal Ca 2+ -and total ATPase activities. Brain Na + K + -, Ca 2+ -and total ATPase activities were depressed in co-exposure while Mg 2+ -ATPase was up-regulated. Lead potentiated DEHP-induced inhibition of brain total -ATPase while co-treatment produced antagonistic effects on brain Ca 2+ -ATPase. The findings of this study highlight organ specific variations in response to combined lead and DEHP exposure in rats.

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Section: Discussionmentioning

confidence: 99%