Influence of calcium ions on the stability, microstructure and in vitro digestion fate of zein-propylene glycol alginate-tea saponin ternary complex particles for the delivery of resveratrol

Yang, Wei; Li, Chang; Zhang, Liang; Dai, Lei; Yang, Shufang; Liu, Jinfang; Mao, Like; Yuan, Fang; Gao, Yanxiang

doi:10.1016/j.foodhyd.2020.105886

Cited by 66 publications

(40 citation statements)

References 47 publications

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“…Fluorescence spectra of bioactive‐loaded nanovehicles including (a) resveratrol in various levels of γ‐CD, (b) cyclodextrin metal–organic framework, and (c) cyclodextrin metal–organic framework/chitosan (0, 0.2, 0.4, 0.6, 0.8, and 1.0 mg/mL) (Reprinted with permission from Qiu et al., 2020); (d) zein, curcumin–piperine–zein–carrageenan nanoparticles (CPZC), and nanoparticles cross‐linked by cationic calcium ions (CPZCCa 2+ ) (Reprinted with permission from Chen et al., 2020); (e and f) resveratrol and coenzyme Q10 co‐encapsulated zein– propylene glycol alginate nanoparticles at different rhamnolipid concentrations (Reprinted with permission from Wei, Yu, et al., 2020)…”

Section: Fs: Working Principlesmentioning

confidence: 99%

“…Wei, Yang et al. (2020) designed food‐grade nanocomplexes for the co‐delivery of resveratrol–coenzyme Q10 and employed FS to notice the polarity of surrounding environment for intrinsic fluorophore of proteins. According to Figure 7e, the produced propylene glycol alginate–zein nanocomplexes displayed an emission peak positioned at 304 nm when excited at 280 nm.…”

Section: Fs: Working Principlesmentioning

confidence: 99%

“…Nanocarrier matrices can efficiently shield the drug/nutraceutical compounds via encapsulating them in a suitable membrane relying on their either hydrophilic/hydrophobic nature (incorporation, dispersion, or even absorption) or via covalent linking (Babazadeh, Vahed, & Jafari, 2020;Cho, Wang, Nie, & Shin, 2008;Rakotoarisoa, Angelov, Garamus, & Angelova, 2019;Rostamabadi, Falsafi, & Jafari, 2019a. Fundamentally, these nanocarriers have been developed to address the blind spots in conventional delivery methods of bioactive agents (Blanco, Shen, & Ferrari, 2015;Wei, Li, et al, 2020; Wei, Sun, Dai, Zhan, & Gao, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Fundamentally, these nanocarriers have been developed to address the blind spots in conventional delivery methods of bioactive agents (Blanco, Shen, & Ferrari, 2015; Wei, Li, et al., 2020; Wei, Sun, Dai, Zhan, & Gao, 2018). Although modern vehicles typically release the loaded molecules in a slow manner and longer periods of time.…”

Section: Introductionmentioning

confidence: 99%

“…Although modern vehicles typically release the loaded molecules in a slow manner and longer periods of time. The size diminution of encapsulation tools offers several bioadhesive improvement properties, that is, enhanced adhesive power and sustained gastrointestinal (GI) transit time, providing a greater bioavailability of nutraceutical components (Amsalem et al., 2017; Arnon‐Rips, Porat, & Poverenov, 2019; Falsafi, Rostamabadi, et al, 2020; Wei, Zhang,et al., 2019; Wei, Yang et al., 2020). In virtue of this manner, nanocarriers can be utilized to render a site‐specific delivery by promoting the controlled/sustained release mechanism of therapeutic agents at the proper place and time.…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the structural properties of bioactive‐loaded nanocarriers with modern analytical tools

Rostamabadi

Falsafi

Assadpour

et al. 2020

Comp Rev Food Sci Food Safe

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With the emergence of nanocarriers for offering smart transformers improving the bioavailability and functionality of food bioactive compounds, a critical issue is experimental and analytical evaluation of the bioactive-loaded nanocarriers; so, further technical advancements are necessary for the precise structural characterization of these nanodelivery systems and application of sophisticated analytical techniques. Here, we have portrayed the current progress in the structural characterization approaches including X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, fluorescence spectroscopy, circular dichroism, Fourier-transform infrared spectroscopy, nuclear magnetic resonance, X-ray photoelectron spectroscopy, and small-angle X-ray scattering/small-angle neutron scattering as powerful and informative tools to have a better control on the design, development, and appraisal of nanoengineered bioactive delivery systems. Different examples and case studies have been tabulated along with illustrative and schematic representation of relevant results. An emerging view concerning the challenges for future structural characterization of these systems is also discussed in detail.

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Section: Fs: Working Principlesmentioning

confidence: 99%

Section: Fs: Working Principlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluating the structural properties of bioactive‐loaded nanocarriers with modern analytical tools

Rostamabadi

Falsafi

Assadpour

et al. 2020

Comp Rev Food Sci Food Safe

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Impact of calcium‐reinforcement on stability, bioavailability, and bioactivity of quercetin‐loaded zein/alginate‐pectin nanoparticles

Li,

Zhu,

Zhou

et al. 2024

J Sci Food Agric

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BACKGROUNDCationic calcium ions can crosslink anionic alginate and pectin molecules. It was hypothesized that calcium crosslinking would improve the stability and functionality of biopolymer nanoparticles consisting of zein cores coated by alginate‐pectin shells. The effects of calcium ion addition on the structural, physicochemical, and gastrointestinal properties of quercetin‐loaded zein/alginate‐pectin nanoparticles were therefore investigated.RESULTSThe nanoparticles remained stable to aggregation at calcium ion concentrations of 9 mmol/L or less but aggregated and sedimented at higher concentrations. Calcium ion reinforcement increased the particle dispersion stability even at NaCl concentrations up to 1.4 molL‐1. The presence of the calcium ions also reduced quercetin release during the early stages of simulated gastrointestinal digestion but increased its release during the later stages. The relatively high release (56.1%) of quercetin from the calcium‐reinforced nanoparticles after digestion resulted in higher intracellular antioxidant activities. The pharmacokinetics of the encapsulated quercetin was measured after its oral administration to rats. The maximal concentration (Cmax) of quercetin in rat plasma for calcium‐reinforced nanoparticles was 6.1% higher than non‐reinforced nanoparticles; the half‐life (t1/2) increased by 17.5%, and the mean retention time (MRT) was 10.0% higher (P < 0.05).CONCLUSIONThese results suggest that calcium ion addition improved the performance and bioavailability of nutraceutical‐loaded biopolymer nanoparticles. This might find application in the food and beverage industry. © 2024 Society of Chemical Industry.

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Nanoencapsulation and delivery of bioactive ingredients using zein nanocarriers: approaches, characterization, applications, and perspectives

Lei,

Lee

2024

Food Sci Biotechnol

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Influence of calcium ions on the stability, microstructure and in vitro digestion fate of zein-propylene glycol alginate-tea saponin ternary complex particles for the delivery of resveratrol

Cited by 66 publications

References 47 publications

Evaluating the structural properties of bioactive‐loaded nanocarriers with modern analytical tools

Evaluating the structural properties of bioactive‐loaded nanocarriers with modern analytical tools

Impact of calcium‐reinforcement on stability, bioavailability, and bioactivity of quercetin‐loaded zein/alginate‐pectin nanoparticles

Nanoencapsulation and delivery of bioactive ingredients using zein nanocarriers: approaches, characterization, applications, and perspectives

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