Influence of calendar period on the association between BMI and coronary heart disease: A meta‐analysis of 31 cohorts

Abstract

Objective: The association between obesity and coronary heart disease (CHD) may have changed over time, for example due to improved pharmacological treatment of CHD risk factors. This meta-analysis of 31 prospective cohort studies explores the influence of calendar period on CHD risk associated with body mass index (BMI). Design and Methods: The relative risks (RRs) of CHD for a five-BMI-unit increment and BMI categories were pooled by means of random effects models. Meta-regression analysis was used to examine the influence of calendar period (>1985 v 1985) in univariate and multivariate analyses (including mean population age as a covariate). 16 and 10). However, in the multivariate analysis, only mean population age was independently associated with the RRs for a five-BMI-unit increment and obesity (À29(95%CI: À55: À5)) and À31(95%CI: À66:3), respectively) per 10-year increment in mean age).Conclusion: This study provides no consistent evidence for a difference in the association between BMI and CHD by calendar period. The mean population age seems to be the most important factor that modifies the association between the risk of CHD and BMI, in which the RR decreases with increasing age.

Associations of body condition score with health conditions related to overweight and obesity in cats

“…Similar to previous studies, cardiac conditions did not show sig nificant association with BCS in cats (Scarlett & Donoghue 1998, Lund et al 2005, Öhlund et al 2018. In contrast, O&O is iden tified as a risk factor for many heart diseases in humans, includ ing coronary heart disease (Guh et al 2009, De Hollander et al 2013, Lu et al 2014, heart failure (Guh et al 2009, Aune et al 2016) and atrial fibrillation (Lavie et al 2009). This is thought to be via various mechanisms, such as hypertension, that are related to an increased adipose tissue mass (Poirier et al 2006, Lavie et al 2009).…”

Addition of estimated cardiorespiratory fitness to the clinical assessment of 10-year coronary heart disease risk in asymptomatic men

“…each variable known to be independently associated with CHD and CHD-mortality. (Fitzgerald and Jarrett, 1992, Jousilahti et al, 1996, de Hollander et al, 2013, Dyer et al, 1980, Gillman et al, 1993, Rexrode et al, 1998, Rimm et al, 1995, Bijnen et al, 1994, Batty and Lee, 2004, Berlin and Colditz, 1990, Slattery et al, 1989). The addition of the aforementioned variables may explain e-CRF's incremental, additional protective effect on CHD mortality and slight improvement on FRS' predictive power.…”

Addition of Estimated Cardiorespiratory Fitness to the Clinical Assessment of 10-Year Coronary Heart Disease Risk in Asymptomatic Men

“…each variable known to be independently associated with CHD and CHD-mortality. (Fitzgerald & Jarrett, 1992;Jousilahti et al, 1996;de Hollander et al, 2013;Dyer et al, 1980;Gillman et al, 1993;Rexrode et al, 1998;Rimm et al, 1995;Bijnen et al, 1994;Batty & Lee, 2004;Berlin & Colditz, 1990;Slattery et al, 1989). The addition of the aforementioned variables may explain e-CRF's incremental, additional protective effect on CHD mortality and slight improvement on FRS' predictive power.…”