Influence of capsaicin-sensitive afferent neurons and nitric oxide (NO) on cerulein-induced pancreatitis in rats

Dembiński, Artur; Warzecha, Zygmunt; Konturek, P J; Ceranowicz, Piotr; Konturek, Stanisław J.

doi:10.1007/bf02787366

Cited by 20 publications

(5 citation statements)

References 45 publications

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“…There is increasing number of evidence, that improvement of blood flow betters wound healing [84]. Disturbances in pancreatic microcirculation is another, well described, important mechanism which has its place in the pathophysiology of AP [26,28,53,[85][86][87].…”

Section: Discussionmentioning

confidence: 99%

“…Rats were anesthetized with ketamine (50 mg/kg i.p., Bioketan, Vetoquinol Biowet, Gorzów Wielkopolski, Poland) at each time of observation. The abdominal cavity was opened to visualize the pancreas and pancreas, pancreatic blood flow was assessed using laser Doppler flowmeter (PeriFlux 4001 Master Monitor, Perimed AB, Järfälla, Sweden) according to the technique described previously in details [53][54][55]. The results were expressed as precent change from value obtained in saline-treated rats without induction of AP.…”

Section: Determination Of the Pancreatic Blood Flowmentioning

confidence: 99%

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Healing Effect of Warfarin in the Course of Cerulein-Induced Acute Pancreatitis

Konarska-Bajda¹,

Ceranowicz²,

Cieszkowski³

et al. 2023

Preprint

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Acute pancreatitis (AP) is the most common gastrointestinal disease leading to hospitalizations. The development of AP leads to damage of the pancreatic microcirculation with a cascade of subsequent events resulting, among others, in coagulopathy. Previous research showed that anticoagulants can be an important therapeutic agent. Heparin and acenocoumarol can alleviate the course of AP, as well as accelerate healing and post-inflammatory regeneration of the pancreas. The aim of this study was to check whether warfarin, a drug with more stable effects than acenocoumarol, affects the healing and regeneration of the pancreas in the cerulein-induced AP. AP was evoked in Wistar male rats by intraperitoneal administration of cerulein. The first dose of warfarin (45, 90 or 180 µg/kg/dose) was administered 24 hours after the first dose of cerulein and the doses of warfarin were repeated once a day in subsequent 10 days. The severity of acute pancreatitis was assessed immediately after the last dose of cerulein, as well as 1, 2, 3, 5, and 10 days after AP induction. Treatment with warfarin dose-dependently increased interna-tional normalized ratio (INR) and attenuated the severity of pancreatitis in histological ex-amination and accelerated pancreatic recovery. Those effects were accompanied with a faster reduction in the pancreatitis-evoked increase in serum activity of amylase and lipase, serum concentration of pro-inflammatory interleukin-1β, and plasma level of D-Dimer. In addition, treatment with warfarin decreased pancreatic weight and improved pancreatic blood flow in rats with AP. The therapeutic effect was particularly pronounced after the administration of warfarin at a dose of 90 µg/kg/dose. Conclusion: Administration of warfarin accelerates re-generation of the pancreas and recovery in the course of cerulein-induced mild-edematous acute pancreatitis.

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Section: Discussionmentioning

confidence: 99%

Section: Determination Of the Pancreatic Blood Flowmentioning

confidence: 99%

Healing Effect of Warfarin in the Course of Cerulein-Induced Acute Pancreatitis

Konarska-Bajda¹,

Ceranowicz²,

Cieszkowski³

et al. 2023

Preprint

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“…An increasing body of evidence shows that changes in the gut microbiota may contribute to the development of functional bowel disorders that are possibly secondary to dysbiosis of the gut microbiota (28) . Possibly, the link between constipation and microbiota is the small intestinal bacterial overgrowth, which has been shown to be associated with prolonged small bowel transit time in methane production microbiota (69,70) . More evidence for the effectiveness of specific probiotic strains, and more randomized clinical studies with CIC patients utilizing those well-defined probiotics strains (or combinations) are necessary, as well as education of healthcare professionals on the increased utilisation of probiotics for constipation by the public (69) .…”

Section: Probioticsmentioning

confidence: 99%

“…Despite lack of studies on the use of enemas in CIC, they continue to be used (38,70) . The effect of enemas will depend on the amount of liquid delivered to the rectum (usually between 5-150 mL of glycerine, saline solution, etc.…”

Section: Enemasmentioning

confidence: 99%

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Diagnosis and Management of Chronic Idiopathic Constipation: A Narrative Review From a Brazilian Expert Task Force

Passos

ALVARIZ

ANDRÉ

et al. 2022

Arq. Gastroenterol.

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Background Chronic idiopathic constipation (CIC) is a condition that widely affects the global population, represents relevant healthcare resource utilization and costs, and impacts the individual’s well-being. Objective To review the consensus of expert societies and published guidelines on the diagnosis and treatment of CIC in adults, seeking to assist reasoning and decision-making for medical management of patients with CIC and provide a practical reference material. Methods A Brazilian medical task force searched the scientific literature in the following electronic databases: MEDLINE/PubMed, SciELO, EMBASE and Cochrane, using the following descriptors: chronic constipation, diagnosis, management of chronic constipation. In addition, a review of articles on the mechanism of action, safety, and efficacy of therapeutic options available in Brazil was carried out. Results The diagnostic approach and the understanding of the pathophysiology present in CIC are essential items to indicate the appropriate therapy and to understand the ecosystem of the patient’s needs. Conclusion CIC is a common condition in adults, occurring more frequently in the elderly and in women. Proper management is defined by detailed medical history and physical examination, together with appropriate therapeutics, regardless pharmacological or not, and depending on the best moment of indication. This way, the impact on quality of life is also optimized.

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The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

et al. 2017

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Pancreatitis is a gastrointestinal disease with a worldwide sharp surge during the past decade. Pancreatitis includes acute and chronic subtypes, which are graded based on the amount of pancreatic inflammation. Phytoconstituents represent a promising class of therapeutic agents with wide acceptability not only based on folk practices but sound presence of pharmacological and molecular evidences. Growing research evidence indicates that different molecular mechanisms are involved in their protective effect. Many phytoremedies have been tried for the treatment of pancreatic injuries and have shown success in preclinical animal models of pancreatitis. The literature was largely collected through PubMed and Google scholar database. A large proportion of phytochemicals targets the inflammatory cascade and modulates the overtly acting redox balance among which nuclear factor kappa-light-chain-enhancer of activated B cells is the key molecule. Inhibition of apoptosis (artemisinin, embelin), inflammasome (withaferin A), neutrophil rolling (fucoidan), Ca release (caffeine), mitogen activated protein kinase (guggulsterone) and many other novel mechanisms apart from antioxidant effect have been postulated behind the protective effect of phytoconstituents. The present review deals to fill the gap of hitherto unavailable comprehensive review on various plant products screened for the treatment of pancreatitis. The possible mechanistic profile of these phytochemicals is summarized. Copyright © 2017 John Wiley & Sons, Ltd.

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Influence of capsaicin-sensitive afferent neurons and nitric oxide (NO) on cerulein-induced pancreatitis in rats

Cited by 20 publications

References 45 publications

Healing Effect of Warfarin in the Course of Cerulein-Induced Acute Pancreatitis

Healing Effect of Warfarin in the Course of Cerulein-Induced Acute Pancreatitis

Diagnosis and Management of Chronic Idiopathic Constipation: A Narrative Review From a Brazilian Expert Task Force

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

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