Influence of Caralluma adscendens Var. attenuata cold cream on UV-B damaged skin epidermal cells: a novel approach

Sundar, Madasamy; Suresh, S.; Lingakumar, K.

doi:10.1007/s13205-021-02694-y

Cited by 9 publications

(6 citation statements)

References 71 publications

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“…Thus, our findings suggest that C. bhurenderiana offers protection against free radical mediated oxidative damage. Consistent with these results earlier reports have reported that the plants containing high phenol and flavonoids content exhibited inhibition of DNA damage (22). Further Sundar et al, reported that the extracts of C.adscendence were used in formulation of a cold cream that prevented the skin damage mediated by ultra violet rays in an in vitro model of epidermal cells (23).…”

Section: Discussionsupporting

confidence: 67%

Phytochemical screening and in vitro evaluation of antioxidant and DNA inhibition activity of Caralluma bhupenderiana Sarkaria

Pachipala¹,

Vemula²,

Reddy³

et al. 2022

Biomedicine

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Introduction and Aim: Phytochemicals isolated from medicinal plants have been receiving greater attention owing to their potential therapeutic efficiency. Despite rapid developments in the field of modern medicine various herbal medications are being used to treat different types of health disorders. Caralluma bhupenderiana sarkaria is an endemic species of the genus Caralluma. Although selected species of Caralluma have been investigated for their medicinal properties, no studies have addressed the composition of bioactive phytochemicals and its therapeutic properties. The objective was to screen the endogenous composition of C.bhupenderiana extract and evaluate its antioxidant and DNA damaging inhibitory activity.Materials and Methods: Antioxidant potential of C. bhupenderiana was determined by measuring the ability of the extracts to scavenge free radicals. Chemical bonding and structural aspects of the phytochemicals were determined by FT-IR and GC-MS. Plasmid DNA (pBR322) damage inhibition was determined by photolyzing H2O2 and exposing to ultra-violet radiation. Results:The extract was rich in flavonoids, phenols, quinones, glycosides and saponins. FT-IR analysis revealed the presence of functional groups to be 'polymeric' OH stretch, /Methylene C-H asymmetric, esters with double bond, cyclic alkene/organic nitrates, nitro compound, ammonium ion, sulfonates. C. bhupenderiana exhibited significant antioxidant activity as evidenced by its free radical scavenging activity. The extract also exhibited complete protection against DNA damage caused by UV irradiation. Conclusion:C. bhupenderiana contains various endogenous phytochemicals that offer high antioxidant potential along with significant ability to attenuate DNA damage. C. bhupenderiana is highly therapeutic in nature and can be a good candidate for developing novel pharmacological and therapeutic molecules.

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Section: Discussionsupporting

confidence: 67%

Phytochemical screening and in vitro evaluation of antioxidant and DNA inhibition activity of Caralluma bhupenderiana Sarkaria

Pachipala¹,

Vemula²,

Reddy³

et al. 2022

Biomedicine

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“…Based on these results, FCA−200 cream showed a high therapeutic efficacy as it resulted in significant fungal colony eradication in the skin epidermal layer, which is consistent with the previous report (Bonifácio et al, 2019 ), where the antifungal activity of Astronium urundeuva was observed in suppression, germination, and inhibition of mycelial growth in female Wistar rats. The high antifungal activity of FCA−200 could be due to the presence of numerous active compounds in the cold cream, such as triterpenes, terpenes, and essential oils, as reported in a previous study (Sundar et al, 2021 ).…”

Section: Resultssupporting

confidence: 60%

“…We showed in our previous report that terpenes and essential oils were present in the methanolic extract of C. adscendens var. attenuata triterpenes (Sundar et al, 2021 ). A previous study has also shown that these plant metabolites are active antimicrobial compounds (Espino et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

Preparation and optimization of medicated cold cream using Caralluma adscendens var. attenuata for the treatment of Candida skin infection

Sundar¹,

Suresh²,

Lingakumar³

2022

bta

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Fungal skin infection is a major skin health issue worldwide. For the treatment of fungal infections, systematic antifungal therapies are frequently prescribed. The aim of this study is to prepare an antifungal cold cream from Caralluma adscendens var. attenuata to treat deep dermal fungal infection in the skin layer. To achieve this, different concentrations of plant extract-based cold cream were prepared, and their in vitro characteristic features such as color, texture, pH, viscosity, spreadability, stability, permeation, were analyzed together with ex vivo evaluation to identify their applicability in the treatment of acute rat skin irritation. After 72 h of induction of Candida albicans infection in rats (7 days, two times/day), C. adscendens var. attenuata cold cream was applied topically. In rats with C. albicans induction without any treatment, adverse skin damages were visible in the form of red rashes, whereas in those with the formulated cold cream application, significantly less skin damage and inflammation were observed on a dose-dependent basis. Moreover, the reduced microbial colonization and histopathology of the rat skin without any treatment indicated the successful invasion of C. albicans and showed the morphological changes caused by candidal infection. However, treatment with the C. adscendens var. attenuata cream significantly inhibited candida colonization and reversed the morphological changes. In addition, the formulated C. adscendens var. attenuata cold cream showed good spreadability, permeation, and viscosity. Hence, it can act as a potent antifungal topical agent for the treatment of C. albicans skin infection without any irritation, thus safeguarding the skin tissue.

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“…50 According to several published reports, it is mainly phenolics, flavanones, and terpenoids of plant extracts that act as reducing and capping agents during the green synthesis of nanozymes, and it is well-known that phenolics are the major antioxidants. 51 Sundar et al 52 reported that in the presence of water, the phenolic component of the leaf extract can quickly donate an electron to the hydroxyl radical, thus neutralizing it.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Spherical Mn₂O₃ Nanozymes from Different Green Precursors for their Innovative Applications in Catalytic Properties and Bioactivity

Shome,

Ali,

Haydar

et al. 2024

ACS Biomater. Sci. Eng.

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Here, spherical Mn 2 O 3 nanozymes were synthesized via a one-step green method using different green precursors, and their physicochemical properties and biological activities were monitored with various green precursors. Powder X-ray diffraction (PXRD) was performed to determine the crystalline properties and phases involved in the formation of cubic Mn 2 O 3 nanozymes. The synthesized nanozymes were spherical and examined by SEM and FESEM studies. All of the samples synthesized using different green precursors exhibited different sizes but similar spherical shapes. Moreover, all green-synthesized nanozymes catalyzed the oxidation reaction of the chromogenic substrate 3,3′5,5′ tetramethylbenzidine (TMB) in the absence of H 2 O 2 , and A2 (lemon-mediated Mn 2 O 3 nanozymes), which the followed Michaelis−Menten kinetics, showed the best activity. Therefore, A2 (lemon-mediated nanozyme) showed oxidasemimicking activity with distinct K m and V max values calculated by the Lineweaver−Burk plot. Furthermore, the current nanozymes demonstrated a significant ability to kill both Gram-negative and Gram-positive bacteria as well as effectively destroy biofilms under physiological conditions. Moreover, the green-mediated nanozymes also displayed ROS-scavenging activity. Our nanozymes exhibited scavenging activity toward OH and O 2 −• radicals and metal chelation activity, which were investigated colorimetrically. Therefore, these nanozymes might be used as effective antibacterial agents and also for the consumption of reactive oxygen species.

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Influence of Caralluma adscendens Var. attenuata cold cream on UV-B damaged skin epidermal cells: a novel approach

Cited by 9 publications

References 71 publications

Phytochemical screening and in vitro evaluation of antioxidant and DNA inhibition activity of Caralluma bhupenderiana Sarkaria

Phytochemical screening and in vitro evaluation of antioxidant and DNA inhibition activity of Caralluma bhupenderiana Sarkaria

Preparation and optimization of medicated cold cream using Caralluma adscendens var. attenuata for the treatment of Candida skin infection

Synthesis of Spherical Mn₂O₃ Nanozymes from Different Green Precursors for their Innovative Applications in Catalytic Properties and Bioactivity

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Influence of Caralluma adscendens Var. attenuata cold cream on UV-B damaged skin epidermal cells: a novel approach

Cited by 9 publications

References 71 publications

Phytochemical screening and in vitro evaluation of antioxidant and DNA inhibition activity of Caralluma bhupenderiana Sarkaria

Phytochemical screening and in vitro evaluation of antioxidant and DNA inhibition activity of Caralluma bhupenderiana Sarkaria

Preparation and optimization of medicated cold cream using Caralluma adscendens var. attenuata for the treatment of Candida skin infection

Synthesis of Spherical Mn2O3 Nanozymes from Different Green Precursors for their Innovative Applications in Catalytic Properties and Bioactivity

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Synthesis of Spherical Mn₂O₃ Nanozymes from Different Green Precursors for their Innovative Applications in Catalytic Properties and Bioactivity