The effect of sintering on the mechanical properties of iron-based vanadium-containing powders with various additives is studied. The results of uniaxial compression testing show that specimens made of the powder without additives and compositions with zinc or copper change their shape from cylindrical to barrel-type with increasing pressure, whereas less dense powder specimens with phosphorus collapse. The cylindrical shape of specimens with graphite as an additive remains unchanged. After sintering, the Brinell hardness for the iron powder without additives and the compositions with zinc or copper decreases, and it increases for the powders with phosphorus and those with graphite, particularly for the composition with graphite. Sintered briquettes with graphite have much higher values of Brinell hardness and compressive strength than the other compositions. The compressive yield strength of the investigated billets has been determined.