Influence of Cardiovascular Risk Burden on Motor Function Among Older Adults: Mediating Role of Cardiovascular Diseases Accumulation and Cognitive Decline

Wang, Zhangyu; Cui, Kaiwang; Song, Ruixue; Qi, Xiaojuan; Buchman, Aron S.; Bennett, David A.; Xu, Weili

doi:10.3389/fmed.2022.856260

Cited by 6 publications

(7 citation statements)

References 49 publications

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“…This exposure enables the active ingredients present in Angelica keiskei to exert more potent antioxidant effects on these cells. Furthermore, previous research conducted a 22-year follow-up analysis on 1378 physically healthy participants, with a mean age of 79.3 ± 7.3 years, and found a correlation between higher cardiovascular risk burden in older adults and a faster decline in physical functions, including agility, gait, and hand strength [ 51 ]. It is possible that the enhancement of the musculoskeletal system by Angelica keiskei may be partially attributed to improved cardiovascular health.…”

Section: Discussionmentioning

confidence: 99%

Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice

Liu,

Wei,

Wang

et al. 2024

Redox Report

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Objective Angelica keiskei is a medicinal and edible plant that has been reported to possess potent antioxidant properties in several in vitro models, but its effectiveness on naturally aging organisms is still lacking. This study explores the antioxidant and health-promoting effects of Angelica keiskei in naturally aging mice. Methods We treated 48-week-old mice with Angelica keiskei water extract (AKWE) 30 days, and measured indicators related to aging and antioxidants. In addition, we conducted network pharmacology analysis, component-target molecular docking, real-time PCR, and MTS assays to investigate relevant factors. Results The results indicated that administration of AKWE to mice led to decrease blood glucose levels, improve muscle fiber structure, muscle strength, gait stability, and increase levels of glutathione and superoxide dismutase in serum. Additionally, it decreased pigmentation of the heart tissues. Angelica keiskei combats oxidative stress by regulating multiple redox signaling pathways, and its ingredients Coumarin and Flavonoids have the potential to bind to SIRT3 and SIRT5. Conclusions Our findings indicated the potential of Angelica keiskei as a safe and effective dietary supplement to combat aging and revealed the broad prospects of medicinal and edible plants for addressing aging and age-related chronic diseases.

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Section: Discussionmentioning

confidence: 99%

Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice

Liu,

Wei,

Wang

et al. 2024

Redox Report

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“…For instance, cardiovascular disease may increase the risk of both hearing loss 33 and impaired mobility. 34 While we have attempted to mitigate confounding by controlling for several comorbidities, it is essential to acknowledge that there may be unaccounted-for confounders beyond the scope of the NHIS dataset. 7 Regardless of the underlying mechanism, however, mobility challenges in individuals with hearing loss may exacerbate their overall morbidity.…”

Section: Discussionmentioning

confidence: 99%

“…One must also consider potential confounding factors. For instance, cardiovascular disease may increase the risk of both hearing loss 33 and impaired mobility 34 . While we have attempted to mitigate confounding by controlling for several comorbidities, it is essential to acknowledge that there may be unaccounted‐for confounders beyond the scope of the NHIS dataset 7 .…”

Section: Discussionmentioning

confidence: 99%

Association Between Hearing Difficulty and Mobility in Adults of All Ages: National Health Interview Survey

Joo,

Huang,

Schoo

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveTo investigate the relationship between hearing difficulty and measures of mobility for US adults.Study DesignCross‐sectional study.Setting2021 National Health Interview Survey.MethodsThe survey asked US adults about hearing difficulty and mobility measures, including difficulty walking 100 yards, difficulty climbing 12 steps, and injury from falling within the past 3 months. Multivariable logistic regressions examined the associations between hearing and mobility outcomes, controlling for visual difficulty, medical comorbidities, and various demographic characteristics (age [18‐39, 40‐64, 65+], race/ethnicity, sex, socioeconomic status).ResultsThe 2021 NHIS surveyed 29,467 adults, representing 253 million people in weighted responses (52% female; mean age 48.3, standard deviation = 18.6). Controlling for covariates, hearing difficulty was associated with increased odds of difficulty walking 100 yards (odds ratio, OR = 1.47, P < .001), difficulty climbing stairs (OR = 1.62, P < .001), and injury from falling in the past 3 months (OR = 1.51, P < .001). There was a significant interaction between age and hearing difficulty for injurious falls; stratifying by age revealed that younger adults (ages 18‐39) with hearing difficulty were more likely to report recent harmful falls than their normal hearing peers; this increased risk was greater in magnitude than that observed comparing older adults with and without hearing difficulty.ConclusionThe hearing difficulty is associated with worsened mobility for US adults and may be a stronger independent predictor of injury from falls for younger adults as compared to older adults. These findings can inform interventions to reduce the burden of declining mobility in adults with hearing difficulty.

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“…Gait disturbance is a prevalent chronic disorder among community-dwelling older adults, leading to an increased risk of falls, morbidity, and mortality [ 1 – 3 ]. Previous studies have shown that an increased cardiovascular risk is associated with impaired gait function, specifically decreased gait speed [ 4 , 5 ]. Carotid atherosclerosis, primarily measured by carotid intima-media thickness (IMT), is associated with a higher risk of gait disorders, such as decreased walking speed and impaired balance ability [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Mobility-related brain regions linking carotid intima-media thickness to specific gait performances in old age

Zhang,

Lu,

Fan

et al. 2024

BMC Geriatr

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Background Gait disturbance is common in older adults with vascular diseases. However, how carotid atherosclerosis affects gait remains poorly understood. The objectives were to investigate the associations between carotid intima-media thickness and specific gait performances and explore the potential role of brain structure in mediating these associations. Methods A cross-sectional analysis of data from the Taizhou Imaging Study was conducted, including 707 individuals who underwent both gait and carotid ultrasound examinations. Gait assessments include the Timed-Up-and-Go test, the Tinetti test, and quantitative gait assessment using a wearable device. Quantitative parameters were summarized into independent gait domains with factor analysis. Magnetic resonance images were obtained on a 3.0-Tesla scanner, and the volumes of fifteen brain regions related to motor function (primary motor, sensorimotor), visuospatial attention (inferior posterior parietal lobules, superior posterior parietal lobules), executive control function (dorsolateral prefrontal cortex, anterior cingulate), memory (hippocampus, entorhinal cortex), motor imagery (precuneus, parahippocampus, posterior cingulated cortex), and balance (basal ganglia: pallidum, putamen, caudate, thalamus) were computed using FreeSurfer and the Desikan-Killiany atlas. Mediation analysis was conducted with carotid intima-media thickness as the predictor and mobility-related brain regions as mediators. Results Carotid intima-media thickness was found to be associated with the Timed-Up-and-Go performance (β = 0.129, p = 0.010) as well as gait performances related to pace (β=-0.213, p < 0.001) and symmetry (β = 0.096, p = 0.045). Besides, gait performances were correlated with mobility-related brain regions responsible for motor, visuospatial attention, executive control, memory, and balance (all FDR < 0.05). Notably, significant regions differed depending on the gait outcomes measured. The primary motor (41.9%), sensorimotor (29.3%), visuospatial attention (inferior posterior parietal lobules, superior posterior parietal lobules) (13.8%), entorhinal cortex (36.4%), and motor imagery (precuneus, parahippocampus, posterior cingulated cortex) (27.3%) mediated the association between increased carotid intima-media thickness and poorer Timed-Up-and-Go performance. For the pace domain, the primary motor (37.5%), sensorimotor (25.8%), visuospatial attention (12.3%), entorhinal cortex (20.7%), motor imagery (24.9%), and balance (basal ganglia: pallidum, putamen, caudate, thalamus) (11.6%) acted as mediators. Conclusions Carotid intima-media thickness is associated with gait performances, and mobility-related brain volume mediates these associations. Moreover, the distribution of brain regions regulating mobility varies in the different gait domains. Our study adds value in exploring the underlying mechanisms of gait disturbance in the aging population.

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Influence of Cardiovascular Risk Burden on Motor Function Among Older Adults: Mediating Role of Cardiovascular Diseases Accumulation and Cognitive Decline

Cited by 6 publications

References 49 publications

Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice

Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice

Association Between Hearing Difficulty and Mobility in Adults of All Ages: National Health Interview Survey

Mobility-related brain regions linking carotid intima-media thickness to specific gait performances in old age

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