Influence of carotid body ablation on erythropoietin production in rabbits

Lg, Paulo; Fink, GD; Bl, Roh; Jw, Fisher

doi:10.1152/ajplegacy.1973.224.2.442

Cited by 11 publications

(5 citation statements)

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“…The secretion of Erythropoietin in hypoxic rats was also enhanced by the section of the sinus nerves. This result confirms similar reports in the cat, rabbit and rat (Hansen, Fogh, Mollgard & Sorensen, 1973;Paulo, Fink, Roh & Fisher, 1973;Beynon & Balfour, 1973). The results of the present experiments make it clear that the secretion of the hormone is only elevated under these conditions because of the exaggerated fall that occurs in the arterial oxygen tension of denervated animals during hypoxia.…”

Section: Discussionsupporting

confidence: 92%

The influence of the autonomic nervous system in the control of erythropoietin secretion in the hypoxic rat.

Beynon¹

1977

The Journal of Physiology

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SUMMARY1. Erythropoietin has been measured in the serum of hypoxic rats that have been exposed to 6 hr of hypoxia, by use of a biological assay.2. The effects of section of splanchnic, renal and sinus nerves on the concentration of Erythropoietin present in the serum of the hypoxic animals has been investigated.3. Serum levels of Erythropoietin were reduced in the hypoxic animals immediately after cutting the splanchnic nerves, but unaltered one week after the operation.4. The concentration of Erythropoietin in the serum of hypoxic rats was increased by the section of the renal nerves. Section of the sinus nerves abolished the effect.5. Elevated levels of Erythropoietin were present in the sera of hypoxic rats immediately after section of the sinus nerves. The effect was still obtained when the animals were exposed to hypoxia 1 week after cutting the nerves, though in attenuated form.6. The rise in the concentration of the hormone after chronic section of the sinus nerves was estimated as 261 % (fiducial limits 167-513, P = 0.05), by parallel line bio-assay.7. The concentration of Erythropoietin in the serum of hypoxic rats was progressively elevated as the arterial P02 of the animals was reduced.Section of the sinus nerves did not alter the secretion of Erythropoietin in these experiments.

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Section: Discussionsupporting

confidence: 92%

The influence of the autonomic nervous system in the control of erythropoietin secretion in the hypoxic rat.

Beynon¹

1977

The Journal of Physiology

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“…One might speculate that carotid body cells are able to synthesize their own Epo. Several decades ago, however, some authors found that cat and rabbit carotid bodies do not produce Epo under normoxic or hypoxic conditions (Hansen et al 1973; Paulo et al 1973). Considering the high level of Epo in plasma and more, carotid bodies are among the most irrigated organs in the organism (5–6 folds/brain, Gonzales et al 1994) these results are consistent.…”

Section: Discussionmentioning

confidence: 99%

Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies

Soliz

Joseph

Soulage

et al. 2005

The Journal of Physiology

128

161

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Apart from its role in elevating red blood cell number, erythropoietin (Epo) exerts protective functions in brain, retina and heart upon ischaemic injury. However, the physiological non-erythroid functions of Epo remain unclear. Here we use a transgenic mouse line (Tg21) constitutively overexpressing human Epo in brain to investigate Epo's impact on ventilation upon hypoxic exposure. Tg21 mice showed improved ventilatory response to severe acute hypoxia and moreover improved ventilatory acclimatization to chronic hypoxic exposure. Furthermore, following bilateral transection of carotid sinus nerves that uncouples the brain from the carotid body, Tg21 mice adapted their ventilation to acute severe hypoxia while chemodenervated wild-type (WT) animals developed a life-threatening apnoea. These results imply that Epo in brain modulates ventilation. Additional analysis revealed that the Epo receptor (EpoR) is expressed in the main brainstem respiratory centres and suggested that Epo stimulates breathing control by alteration of catecholaminergic metabolism in brainstem. The modulation of hypoxic pattern of ventilation after I.V. injection of recombinant human Epo in WT mice and the dense EpoR immunosignal observed in carotid bodies showed that these chemoreceptors are sensitive to plasma levels of Epo. In summary, our results suggest that Epo controls ventilation at the central (brainstem) and peripheral (carotid body) levels. These novel findings are relevant to understanding better respiratory disorders including those occurring at high altitude.

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“…The question that arises, therefore, is whether the oxygen sensor that controls the production of erythropoietin resides outside or inside the kidney. Results of experiments obtained on animals without functioning arterial ehemoreceptors as well as with artificially perfused kidneys or renal hypoperfusion point toward an intrarenal localization of the oxygen sensor (9,27,50). In this context, the renal oxygen sensor is operationally defined as a receptor mechanism that controls the production of erythropoietin.…”

Section: Introductionmentioning

confidence: 99%