Influence of carrageenan on the rheology and skin permeation of microemulsion formulations

Valenta, Claudia; Schultz, Katharina

doi:10.1016/j.jconrel.2003.11.020

Cited by 101 publications

(44 citation statements)

References 22 publications

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“…23,24 However, due to low retention at the site of application by virtue of low viscosity of nanoemulsion system and inconvenient application, it is often converted into a gel form. [25][26][27][28] Hence, in the present study a gel based colloidal carrier system loaded with CR intended to be used as adjunct therapy for the treatment of inflammation related to arthritic disorders was developed and investigated on a Freund's complete adjuvant (FCA)-induced arthritic rat model. A mechanistic insight to the topical targeting potential of nanoemulsion gel (NEG) was investigated through skin dynamic study by differential scanning calorimetry (DSC), FT-IR microscopy and confocal laser scanning microscopy (CLSM) analysis of the treated rat skin.…”

Section: Introductionmentioning

confidence: 99%

Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation

Naz¹,

Ahmad²

2015

IJN

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The present work investigated the topical delivery potential of nanoemulsion gel loaded with curcumin (CR). CR nanoemulsion (CR-NE) was prepared by spontaneous emulsification method using oil (Labrafac PG/glyceryl triacetate), surfactant:cosurfactant (S mix ) (tween 80/polyethylene glycol [PEG] 400) and water. The pseudo-ternary phase diagrams were constructed and thermodynamic stability testing was performed. Droplet size and zeta potential were evaluated using photon correlation spectroscopy and transmission electron spectroscopy. Six formulations selected with an average droplet size ≤70±2.72 nm showed a fourfold increase in skin permeation as compared to crude CR solution in oil. The formulation CR-NE4 having a flux of 117.04±2.32 µg/cm 2 /h and with maximum retention (42.87%) was selected, characterized (droplet size =41.13±3.34 nm and zeta potential =−33.1±1.45 mV), and incorporated into gel using carbopol-980 (1% w/v). Skin dynamics analyzed by confocal laser scanning microscopy showed maximum deposition of CR up to a depth of 86.98 µm and was in concordance with differential scanning calorimetry and Fourier transform infrared spectroscopy studies that confirmed lipid bilayer disruption, enhancing permeation. A 28-day anti-arthritic evaluation (body weight, paw edema, tibiotarsal joint thickness, TNF-α and IL-1β levels, and histopathology) on Freund’s complete adjuvant induced arthritic rat model after topical application of CR-NE gel in Wistar rats demonstrated substantial reversal of arthritic symptoms. Thus, CR-NE gel possesses potential for therapeutic effects locally in inflammatory arthritic disorders with improved topical bioavailability.

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Section: Introductionmentioning

confidence: 99%

Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation

Naz¹,

Ahmad²

2015

IJN

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“…It is extensively used as thickening, gelling agent, texture enhancer or stabilizer in the food, pharmaceutical and cosmetic industries [4][5][6]. More recently drug delivery systems based on κ-carrageenan gels were tested in vitro [7][8]. In this study the structural properties of κ-carrageenan gels have been correlated to its capability of release an active agent.…”

Section: Introductionmentioning

confidence: 99%

Relation between structural and release properties in a polysaccharide gel system

Mangione

Giacomazza

Cavallaro

et al. 2007

Biophysical Chemistry

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The potential utility of κ-carrageenan gels for preparing drug release devices is here shown. Structural properties of κ-carrageenan gels prepared with different salt composition and containing Ketoprofen sodium salt, as model drug, have been evaluated with static light scattering and rheological measurements. These properties have been correlated with release profiles in vitro at pH 5.5. Release properties from gelled matrices have been compared with those obtained by two commercial products containing the same drug. Results show that: i) in this system it is possible to easily control the gel texture by using different cationic concentration; ii) the kinetics of drug release by κ-carrageenan gels are dependent on the structural properties of matrices; iii) in the typical interval time used in classical local applications, all gel samples release the loaded drug almost completely, at difference with the commercial products. All these findings can provide useful suggestions for the realization of classical topical release systems.

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“…(Santanna et al, 2009, Austad & Taugbøl 1995, firefighting foams, defogging agents, decontamination of the media from chemical and biological agents and many more other application (Solans & Kunieda, 1997). Also, formulation of the cosmetics (Valenta & Schultz, 2004), medicals and food additives are the other important areas that require very exact control and analysis. According to the statitistics, in 2003 about 2 milion m 3 of surfactants, made from fatty alcohols has been consumed (Brackmann & Hager, 2004).…”

Section: Industrial Applicationsmentioning

confidence: 99%

“…Among them is the delivering of genes into the cells (Gupta et al, 2004), with the aim of treatment of disease or diagnosis (Pedersen et al, 2006, Peng et al, 2006, Xu et al, 2011, Rossi et al, 2006, Santra et al, 2005, targeting cancer cell (Tao et al, 2011, Lu et al, 2008, Reithofer et al, 2011, act as vaccine (Sun et al, 2009, Mumper & Cui, 2003, biocatalyss (Stamatis & Xenakis, 1999, Zoumpanioti et al, 2010, Blattner et al, 2006, cosmetics (Chiu & Yang, 1992, Förster et al, 1995, Valenta & Schultz, 2004, Teichmann et al, 2007 or changing the genetic to improve the performance of the targeted cells , Courrier et al, 2004.…”

Section: Applications In Biological and Health Sciencesmentioning

confidence: 99%

Microemulsions - A Brief Introduction

Najjar¹

2012

Microemulsions - An Introduction to Properties and Applications

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Influence of carrageenan on the rheology and skin permeation of microemulsion formulations

Cited by 101 publications

References 22 publications

Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation

Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation

Relation between structural and release properties in a polysaccharide gel system

Microemulsions - A Brief Introduction

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