Influence of CD4+ status on the invasiveness of pneumococcal pneumonia in HIY patients

Clavo-Sánchez, A. J.; Girón-González, José A.; López-Prieto, Dolores; Torres-Tortosa, Manuel; Sánchez-Porto, A

doi:10.1007/bf01690518

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…CD4− T-cell-negative mice are significantly more susceptible to pneumococcal lung infection and bacteraemia than mice with functional CD4+ T-cells [2]. Furthermore, low CD4+ T-cell levels have been shown to be associated with increased risk of bacteraemia in HIV infected patients with pneumococcal pneumonia [12]. In our study, the cases and HIV positive control groups had similar CD4+ cell counts (geometric mean < 200/μl) and therefore the influence of CD4+ cell level on susceptibility cannot be tested.…”

Section: Discussionmentioning

confidence: 99%

Effect of recurrent invasive pneumococcal disease on serum anti-pneumolysin IgG titres in HIV infected adults

Etuwewe

Swann

Hollingshead

et al. 2009

Vaccine

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We measured serum anti-pneumolysin IgG concentrations in a prospective cohort of 34 HIV infected adults who developed recurrent pneumococcal bacteraemia, and compared baseline levels with HIV positive and HIV negative control subjects that remained free of pneumococcal disease. Anti-pneumolysin concentrations in HIV positive cases and controls were higher compared to HIV negative controls. There was no significant difference in levels between HIV positive subjects who did and did not subsequently develop pneumococcal bacteraemia (geometric means 849.1 U/ml vs. 564.6 U/ml, p = 0.059). Anti-pneumolysin IgG titres before, and after the recurrent episode of pneumococcal bacteraemia did not differ significantly (p = 0.95). High levels of anti-pneumolysin IgG do not predict protection from invasive pneumococcal disease or indicate that an effective immune response has occurred in HIV infected patients.

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Section: Discussionmentioning

confidence: 99%

Effect of recurrent invasive pneumococcal disease on serum anti-pneumolysin IgG titres in HIV infected adults

Etuwewe

Swann

Hollingshead

et al. 2009

Vaccine

View full text Add to dashboard Cite

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Pleural effusion in patients infected with the human immunodeficiency virus

Trejo

Giron

Pérez-Guzmán

et al. 1997

Eur. J. Clin. Microbiol. Infect. Dis.

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In order to analyze the etiology, cytological and biochemical characteristics, and outcome of pleural disease in patients infected with HIV, the medical records of 86 HIV-positive patients with pleural effusion were reviewed. Controls were 106 HIV-negative patients with parapneumonic or tuberculous effusion. Most HIV-positive patients were intravenous drug abusers (95.3%). Pleural effusions in HIV-positive patients were caused by infections in 76 (89.4%) cases. Parapneumonic effusion was diagnosed in 59 patients and tuberculous pleuritis in 15 patients. Staphylococcus aureus was the most frequently isolated bacteria. Parameters for differentiating complicated cases of parapneumonic exudate from uncomplicated cases, such as pleural fluid pH < 7.20 (sensitivity 80% vs. 84.3%), pleural fluid glucose < 35 mg/dl (sensitivity 45% vs. 56.25%) pleural fluid LDH > 1600 UI/l (sensitivity 85% vs. 62.50%), showed similar sensitivity in HIV-positive and HIV-negative patients. Monocytes in pleural fluid were significantly decreased in tuberculous pleuritis in HIV-positive patients (506 +/- 425 vs. 1014 +/- 1196 monocytes/ml, p < 0.05). No significant differences were detected in the outcome of HIV-positive and HIV-negative patients with pleural disease. It can be concluded that the pleural effusion was of predominantly infectious etiology in HIV-positive patients from populations with a high prevalence of intravenous drug abuse. Neither the biochemical parameters in pleural fluid nor the outcome differed significantly between HIV-positive and HIV-negative patients.

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