Influence of ceftriaxone on emergence of Clostridium difficile

Abstract

The influence of long-term ceftriaxone administration on the emergence of Clostridium difficile was studied with 80 patients receiving ceftriaxone for 14 days. In five patients (6.3%) C. difficile was cultured. The appearance of gastrointestinal disturbances during treatment with ceftriaxone was common, but the rate of emergence of C. difficile in immunocompetent patients was not high.

Effect of step-down therapy of ceftriaxone plus loracarbef versus parenteral therapy of ceftriaxone on the intestinal microflora in patients with community-acquired pneumonia

“…Loracarbef is approximately 90% absorbed from the gastrointestinal tract after oral administration, and only a minor impact on the intestinal microflora has been reported [5,6]. In contrast, parenteral ceftriaxone is excreted in the bile in high concentrations, resulting in major changes of the intestinal microflora [7–9].…”