Influence of cellulose ether polymers on ketoprofen release from hydrophilic matrix tablets

Vueba, M. L.; Carvalho, Luís A. E. Batista de; Veiga, Francisco; Sousa, João; Pina, M. E.

doi:10.1016/j.ejpb.2004.03.006

Cited by 141 publications

(69 citation statements)

References 38 publications

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“…Sample degradation is ruled out by stability studies on both components of the PMs. 20 Therefore, the present vibrational results should be taken as a clear evidence of the occurrence of ketoprofen-excipient close contacts upon aging, for both ketoprofen:PVP and ketoprofen:LAC (1:1). The spectral modifications presently detected comprise changes to both the band intensity and width (full width at half maximum, FWHM).…”

Section: Resultsmentioning

confidence: 71%

“…[17][18][19][20] Raman spectra of freshly prepared ketoprofen:PVP and ketoprofen:LAC PMs are represented in Figures 1(c) and 2(c), respectively. Both vibrational patterns can be interpreted as almost the direct sum of the pure ketoprofen and excipient spectra, allowing us to assume an absence of noteworthy intermolecular interactions in the newly prepared PMs.…”

Section: Resultsmentioning

confidence: 99%

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Drug–excipient interactions in ketoprofen: A vibrational spectroscopy study

2006

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Ketoprofen (3-benzoyl-a-methylbenzeneacetic acid) is a widely used nonsteroidal antiinflammatory drug (NSAID), always administered in the form of drug-excipient physical mixtures (PMs). The occurrence of possible interactions between ketoprofen and two commonly used excipients-lactose (LAC) and polyvinylpyrrolidone (PVP)-was evaluated, through vibrational spectroscopy techniques [both Raman and Inelastic Neutron Scattering (INS)]. Spectral evidence of drug:excipient close contacts, which were enhanced by aging, was verified for the (1:1) (w:w) (ketoprofen:PVP) and (ketoprofen:LAC) PMs, both by Raman and INS. These interactions were found to involve mainly the central carbonyl and the terminal methyl-carboxylic moieties of the ketoprofen molecule, this being reflected in particular vibrational modes, such as the methyl torsion, the outof-plane CÀ ÀOH bending, and the inter-ring C¼ ¼O stretching. #

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Section: Resultsmentioning

confidence: 71%

Section: Resultsmentioning

confidence: 99%

Drug–excipient interactions in ketoprofen: A vibrational spectroscopy study

2006

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“…A minimum of 6 tablets should Table 4, the average hardness of the tablets of all formulations was within the specified range, as previously described by Vueba et al 13 …”

Section: Hardness Of Tabletsmentioning

confidence: 99%

“…12 Among the cellulose ether derivatives, hydroxypropyl methyl cellulose (HPMC) has been widely investigated for its drug-releasing effect as compared with methyl cellulose and hydroxypropyl cellulose (HPC). 13 Carboxy methyl cellulose (CMC) sodium, is described by the United States Pharmacopeia (USP) as the sodium salt of poly carboxy methyl ether of cellulose. CMC or cellulose gum, often used as a sodium salt, is a derivative of cellulose (a beta-glucopyranose polymer) with carboxy methyl groups (-CH 2 -COOH) attached to the hydroxyl groups of the glucopyranose backbone.…”

Section: Introductionmentioning

confidence: 99%

Design, Formulation and In-Vitro Evaluation of Sustained Release Tablet Formulations of Levosulpiride

Samie¹,

Bashir²,

Abbas³

et al. 2018

tjps

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ÖZAmaç: Levosulpirid, çeşitli gastrik bozuklukların tedavisinde yaygın olarak kullanılan bir gastroprokinetik ajandır; bununla birlikte, kısa yarı ömrü ve artan dozlama sıklığı, uyumsuzluk ve olası yan etkilere yol açar. Bu çalışmanın asıl amacı, biyolojik olarak resorbe olabilen selüloz türevlerini içeren Levosulpiridin sürekli salımlı bir formülasyonunu geliştirmektir. Gereç ve Yöntemler: Levosulpiridinin sürekli salım formülasyonları, salım modifiye eden polimerler olarak CMC sodyum, HPC ve HPMC gibi çeşitli selüloz türevlerinin farklı polimer-etkin madde ağırlık oranlarında kullanımıyla direkt basım yoluyla hazırlandı. Daha sonra, toz karışımları ve basılmış tabletler basım öncesi ve basım sonrası değerlendirmeye ve aynı zamanda FTIR analizlerine tabi tutuldu. UV/görünür ışık spektrofotometresi ile 214 nm dalga boyunda pH 6.8 tampon çözeltisinde model etkin maddenin tüm formülasyonları için in vitro salım çalışmaları gerçekleştirildi. Bulgular: FTIR sonuçları, bileşenler arasındaki etkileşimin fiziksel olduğunu ve farklı kinetik model verilerinden, salım profilinin Higuchi modeline en iyi şekilde uyum gösterdiğini doğruladı, çünkü sonuçlar yüksek doğrusallık gösterdi. Sonuçlar ayrıca, geliştirilmiş sürekli salım formülasyonları arasında F9 formülasyonunun ideal olduğunu gösterdi. Sonuç: Salım geciktirici polimer/taşıyıcı olarak CMC sodyum, HPC ve HPMC kullanılarak levosulpirid sürekli salımlı matrisler, başarıyla hazırlandı. Anahtar kelimeler: Levosulpirid, sürekli salım tabletleri, çözünme, uyum, polimerler Objectives: Levosulpiride is a widely used gastroprokinetic agent in the treatment of various gastric disorders; however, its short half-life and increased dosage frequency leads to non-compliance and possible adverse effects. The prime objective of the current study was to develop a sustained-release formulation of Levosulpiride incorporating bioresorbable cellulose derivatives. Materials and Methods: Sustained-release formulations of Levosulpiride were prepared through direct compression using various cellulose derivatives such as CMC sodium, HPC, and HPMC in different polymer-to-drug weight ratios as release-modifying polymers. The powder blends and compressed tablets were then subjected to pre-compressional and post-compressional evaluation, as well as FTIR analysis. In vitro release studies were performed for all formulations of the model drug in buffer solution of pH 6.8 at a wave length of 214 nm by a UV-visible light spectrophotometer. Results:The FTIR results confirmed that the interaction between components was physical, and from the different kinetic models data, the release profile was best expressed by the Higuchi model because the results showed high linearity. The results also showed formulation F9 to be the ideal one among the developed formulations, exhibiting sustained-release behavior. Conclusion: Levosulpiride sustained-release matrices were prepared successfully using CMC sodium, HPC, and HPMC as the release-retarding polymer/carrier.

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“…As the polymer matrix of chitosan used in this study is swellable in nature, the release data of the drug from these swellable systems can be analyzed according to Korsmeyer et al equation [23,24].…”

Section: Analysis and Computation Of The Cpc Release Datamentioning

confidence: 99%

Chitosan Mucoadhesive Buccal Films: Effect of Different Casting Solvents on Their Physicochemical Properties

Abouhussein

El-Bary

Shalaby

et al. 2016

Int J Pharm Pharm Sci

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Objective: The aim of this work is to investigate the influence of different casting solvents on the physicochemical properties of cetylpyridinium chloride (CPC) chitosan mucoadhesive buccal films.Methods: Screening formulations were prepared by casting solvent technique using organic acids; 1% acetic acid (AA), 1% lactic acid (LA) and inorganic acid; 0.1N HCl (FS1-FS3). Then, 2P 1 P X3P 1 P factorial design study was done using 2 factors; solvent type (AA, LA, Mixture of 0.1N HCl and LA) and solvent concentration (AA and LA; 1%, 2% and mixture of 0.1N HCl: 1% LA; 2:1, 1:2). Films were evaluated for their physicochemical properties through, mechanical properties, mucoadhesion, in vitro release of CPC and antimicrobial activity. Results:The studied factors showed a significant effect on both mucoadhesion and tensile strength. Film casted from 0.1 N HCl was brittle and did not show any elasticity, so it was used in further studies mixed with LA to improve physicochemical properties of the prepared films. Films casted from LA showed swelling for an initial period of 15 min then no more swelling occurred while swelling of those casted from AA occurred throughout approximately 2 h. A film containing 2:1 HCl: LA (F5) dissolved in both media while 1:2 HCl: LA (F6) showed swelling properties. This was reflected on the in vitro release of CPC in which F5 gave higher % released (DER 300 min R54.37%) than the other formulations. Conclusion:Casting solvent was proved to have a significant effect on the physicochemical properties of chitosan CPC mucoadhesive films.

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Influence of cellulose ether polymers on ketoprofen release from hydrophilic matrix tablets

Cited by 141 publications

References 38 publications

Drug–excipient interactions in ketoprofen: A vibrational spectroscopy study

Drug–excipient interactions in ketoprofen: A vibrational spectroscopy study

Design, Formulation and In-Vitro Evaluation of Sustained Release Tablet Formulations of Levosulpiride

Chitosan Mucoadhesive Buccal Films: Effect of Different Casting Solvents on Their Physicochemical Properties

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