Influence of Central Neurotransmitters on Heart Rate Variability in Outbred Rats at Rest and during Acute Stress: Nature of Very-Low-Wave Spectrum Component Revisited

Kurjanova, E. V.; Teplyj, D. L.

doi:10.1007/s10517-010-0862-y

Cited by 10 publications

(3 citation statements)

References 8 publications

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“…By the age of 21 days, the HR reached the maximum values, which was in line with a previous report [9]. This was paralleled by the fi rst increase of spectral power (2.6 times; p<0.001) due to more intense slow waves: 5.8 times for LF (p<0.001) and 19.8 times for VLF (p<0.001), which could indicate stimulation of the cerebral CAergic systems [6] and of suprasegmentary regulation level [1]. Due to more complex wave structure, the cardiac rhythm became less strained (in comparison with that in 14-day-old rats), SI decreased by 1.8 times (p<0.01), but remained signifi cantly higher than 100 arb.…”

Section: Resultssupporting

confidence: 91%

Development of regulation of the cardiac chronotropic function in albino rats during the early postnatal ontogeny according to the results of spectral analysis of heart rhythm variability

2012

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Regulation of the cardiac chronotropic function was studied by spectral analysis of cardiac rhythm variability in HF, LF, and VLF bands in rats at various stages of the early postnatal ontogeny. The inadequacy of the regulatory mechanisms during the first days of life manifested by low power of all waves (particularly HF) in the cardiac rhythm variability spectrum. On day 14 of life, the cardiointerval variability was formed by HF waves, their low power together with increasing heart rate indicating more intense sympathetic effects. On day 21 of life, a potent elevation of the VLF power reflected a stronger centralization of regulation from higher autonomic centers. The age of 28 days was characterized by a sharp increase of HF activity and could be regarded as the turning point in the development of parasympathetic effects and activity of the autonomic regulation contour. From the age of 35 days, the wave power and the proportion of the spectral components of cardiac rhythm variability in albino rats corresponded to the adult pattern; a trend to the central regulation predominance and to greater rigidity of cardiac rhythm formed only with the onset of sexual maturation.

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Section: Resultssupporting

confidence: 91%

Development of regulation of the cardiac chronotropic function in albino rats during the early postnatal ontogeny according to the results of spectral analysis of heart rhythm variability

2012

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“…These findings present new research opportunities, as the power at VLF is related to changes in the humoral system 27 , while DFA fluctuations have been considered useful when analyzing the intrinsic behavior of a system 28 . Finally, the age of the participants influenced the final prediction model of VO 2max , with correlations of r = 0.423 in men and r = 0.212 in women, which has been considered in the development of other prediction models 29 .…”

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confidence: 99%

Heart Rate Variability and Body Composition as Vo2max Determinants

León-Ariza

Botero‐Rosas

Zea-Robles

2017

Rev Bras Med Esporte

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Introduction: The maximum oxygen consumption (VO 2max ) is the gold standard in the cardiorespiratory endurance assessment. Objective: This study aimed to develop a mathematical model that contains variables to determine the VO 2max of sedentary people. Methods: Twenty participants (10 men and 10 women) with a mean age of 19.8±1.77 years were included. For each participant, body composition (percentage of fat and muscle), heart rate variability (HRV) at rest (supine and standing), and VO 2max were evaluated through an indirect test on a cycloergometer. A multivariate linear regression model was developed from the data obtained, and the model assumptions were verified. The obtained model demonstrated the influence exerted by body composition, the autonomic nervous system, and age in the prediction of VO 2max.

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“…The increased LF power following stress was reported by many previous studies utilizing various stress models including psychological stress [ 59 ], social defeat stress [ 13 , 52 ] and the CMS model [ 16 , 17 ]. On the contrary, most studies showed that the HF power was either unchanged [ 60 ] or decreased [ 16 , 17 , 52 ]. Therefore, the increase in HF power at 4 weeks in this study was unexpected.…”

Section: Discussionmentioning

confidence: 99%

Effects of Chronic Mild Stress on Cardiac Autonomic Activity, Cardiac Structure and Renin–Angiotensin–Aldosterone System in Male Rats

Bangsumruaj

Kijtawornrat

Kalandakanond-Thongsong

2022

Veterinary Sciences

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Stress is associated with cardiovascular disease. One accepted mechanism is autonomic imbalance. In this study, we investigated the effects of chronic mild stress (CMS) on cardiac autonomic control, cardiac structure and renin–angiotensin–aldosterone system (RAAS) activity in adult male Sprague Dawley rats. The CMS model provides a more realistic simulation of daily stress. The animals were divided into control and CMS, and were exposed to 4-week mild stressors. The electrocardiogram recording, sucrose intake and parameters related to stress, cardiac alterations and RAAS were determined. The results showed that CMS had lower body weight and higher sucrose intake. The heart rate variability (HRV) revealed that CMS increased autonomic activity without affecting its balance. The increased RAAS activity with upregulated angiotensin type 1 receptor mRNA expression was shown in CMS. The increased sympathetic activity or RAAS was correlated with stress. Moreover, the altered cardiac structure (i.e., heart weight and cardiomyocyte cross-sectional area) were correlated with stress-, sympathetic- and RAAS-related parameters. These indicated that CMS-induced cardiac hypertrophy was the result of both sympathetic and RAAS activation. Therefore, it could be concluded that 4-week CMS in male rats induced negative emotion as shown by increased sucrose intake, and increased cardiac autonomic and RAAS activities, which may be responsible for mild cardiac hypertrophy. The cardiac hypertrophy herein was possibly in an adaptive, not pathological, stage, and the cardiac autonomic function was preserved as the autonomic activities were in balance.

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Influence of Central Neurotransmitters on Heart Rate Variability in Outbred Rats at Rest and during Acute Stress: Nature of Very-Low-Wave Spectrum Component Revisited

Cited by 10 publications

References 8 publications

Development of regulation of the cardiac chronotropic function in albino rats during the early postnatal ontogeny according to the results of spectral analysis of heart rhythm variability

Development of regulation of the cardiac chronotropic function in albino rats during the early postnatal ontogeny according to the results of spectral analysis of heart rhythm variability

Heart Rate Variability and Body Composition as Vo2max Determinants

Effects of Chronic Mild Stress on Cardiac Autonomic Activity, Cardiac Structure and Renin–Angiotensin–Aldosterone System in Male Rats

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